A5090100802- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Patient-Provider Communication in Healthcare
- MRI in cancer diagnosis
- Patient Satisfaction in Healthcare
- Urinary and Genital Oncology Studies
- Healthcare Policy and Management
- Colorectal Cancer Screening and Detection
- Statistical Methods in Clinical Trials
- Urological Disorders and Treatments
- Primary Care and Health Outcomes
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Economic and Financial Impacts of Cancer
- Hormonal and reproductive studies
- Multiple and Secondary Primary Cancers
- Urinary Bladder and Prostate Research
- Innovations in Medical Education
- Pelvic floor disorders treatments
- Medical Malpractice and Liability Issues
- Cardiovascular Disease and Adiposity
Cedars-Sinai Medical Center
2016-2025
GTx (United States)
2019-2021
American Society of Colon and Rectal Surgeons
2018
Prostate Cancer Foundation
2017
University of California, Los Angeles
2010-2016
West Los Angeles College
2013-2016
Accreditation Council for Graduate Medical Education
2016
Naval Medical Center Portsmouth
2016
Greater Lawrence Family Health Center
2016
John Wiley & Sons (United States)
2016
BACKGROUND Patients with bladder cancer are apt to develop multiple recurrences that require intervention. The recurrence, progression, and cancer–related mortality rates were examined in a cohort of individuals high‐grade non–muscle‐invasive cancer. METHODS Using linked Surveillance, Epidemiology, End Results (SEER)‐Medicare data, subjects identified who had diagnosis high‐grade, disease 1992 2002 followed until 2007. Multivariate competing‐risks regression analyses then used examine rates....
Accurate estimation of life expectancy is essential to offering appropriate care men with early-stage prostate cancer, but mortality risks associated comorbidity are poorly defined.To determine the effect age, comorbidity, and tumor risk on other-cause cancer-specific in disease.Prospective cohort study.A nationally representative, population-based cohort.3183 nonmetastatic cancer at diagnosis.Baseline self-reported (scored as a count 12 major comorbid conditions), characteristics, initial...
Abstract Background Physicians in training are at high risk for depression, and physicians practice have a substantially elevated of suicide compared to the general population. The graduate medical education community is currently mobilizing efforts improve resident wellness. Objective We sought provide trainee perspective on current resources support wellness that need be developed ensure an optimal learning environment. Methods ACGME Council Review Committee Residents, 29-member...
Men with low-risk prostate cancer and significant comorbidity are susceptible to overtreatment. The authors sought compare the impact of age on treatment choice in men disease.The sampled 509 diagnosed at Greater Los Angeles Long Beach Veterans Affairs Medical Centers between 1997 2004. Rates aggressive (radical prostatectomy, radiation therapy, brachytherapy) were determined among different ages Charlson scores. Multivariate modeling was used determine influence both variables predicting...
<h3>Importance</h3> Early postoperative ambulation is vital to minimizing length of stay (LOS), but few hospitals objectively measure predict outcomes. Wearable activity monitors have the potential transform assessment ambulation, key implementation data, including whether digitally monitored step count can identify patients at risk for poor efficiency outcomes, are lacking. <h3>Objectives</h3> To define distribution measured daily counts after major inpatient surgical procedures, assess...
Unlike for prostate cancer, active surveillance thyroid cancer has not achieved wide adoption. The parameters by which this approach is feasible are also well defined, nor the effect of patient anxiety.
Abstract BACKGROUND The purpose of this study was to compare predictive factors for the efficacy androgen deprivation therapy (ADT) in men with hormone‐sensitive prostate cancer (HSPC) either (M+) or without (M−) metastases. METHODS A cohort patients identified from a medical oncology practice treated ADT presumed nonlocalized cancer, evaluated using prostate‐specific antigen (PSA) time progression (TTP) and compared associated TTP M− M+ patients. RESULTS In 553 patient 51% were 49% M+....
Abstract BACKGROUND: Accurate estimation of life expectancy is essential for men deciding between aggressive and conservative treatment prostate cancer. The authors sought to assess the competing risks nonprostate cancer mortality among with differing Charlson comorbidity index scores tumor risks. METHODS: conducted a retrospective study 1482 nonmetastatic diagnosed from 1997 2004 at Greater Los Angeles Long Beach Veterans Affairs Medical Centers. They performed Kaplan‐Meier regression...
BACKGROUND Stereotactic body radiotherapy (SBRT) for localized prostate cancer has potential advantages over traditional radiotherapies. Herein, the authors compared national trends in use, complications, and costs of SBRT with those METHODS The identified men who underwent SBRT, intensity‐modulated (IMRT), brachytherapy, proton beam therapy as primary treatment between 2004 2011 from Surveillance, Epidemiology, End Results Program (SEER)‐Medicare linked data. Temporal trend use was assessed...
Patients use online consumer ratings to identify high-performing physicians, but it is unclear if are valid measures of clinical performance. We sought determine whether specialist physicians from 5 platforms predict quality care, value and peer-assessed physician performance.We conducted an observational study 78 representing 8 medical surgical specialties. assessed the association with specialty-specific performance scores (metrics including adherence Choosing Wisely measures, 30-day...
MRI is used to image prostate cancer and target tumors for biopsy or therapeutic ablation. The objective was understand the biology of not visible on that may go undiagnosed untreated. Methods: Prostate cancers invisible multiparametric were macrodissected examined by RNAseq. Differentially expressed genes (DEGs) based visibility status cross-referenced with publicly available gene expression databases identify associated disease progression. Genes potential roles in determining progression...
BACKGROUND Men with major comorbidities are at risk for overtreatment of prostate cancer due to uncertainty regarding their life expectancy. We sought characterize expectancy and treatment in a population‐based cohort men differing ages comorbidity burdens diagnosis. METHODS sampled 96,032 aged ≥66 years early‐stage who had Gleason scores ≤7 were diagnosed during 1991 2007 from the Surveillance, Epidemiology, End Results‐Medicare database. calculated cumulative incidence other‐cause...
Background: Multiparametric MRI (mpMRI) as a non-invasive imaging tool is important in prostate cancer (PCa) detection and localization. Combined with radiomics analysis, features extracted from mpMRI have been utilized to predict PCa aggressiveness. T2 mapping provides quantitative information diagnoses but not routinely available clinical practice. Previous work our group developed deep learning-based method estimate maps clinically acquired T1- T2-weighted images. This study aims evaluate...
207 Background: Circulating tumor cells (CTCs) with a very-small-nuclear (vsn) phenotype (i.e., vsnCTCs) in prostate cancer (PCa) represent distinct subset of CTCs characterized by nuclei smaller than 8.5 μm. Our previous studies established link between vsnCTCs and the presence visceral metastasis. Emerging evidence suggests that reduction emerin (EMD), nuclear envelope protein, contributes to PCa metastasis is associated shape instability. This study aims validate as biomarker metastatic...
Abstract Background: Circulating tumor cells (CTCs) with a very-small-nuclear phenotype (vsnCTCs) in prostate cancer (PCa) are characterized by nuclei smaller than 8.5 μm. Our previous studies established an association between vsnCTCs and visceral metastasis. Reduction of emerin (EMD), nuclear envelope protein, contributes to PCa metastasis shape instability. Here we investigated the correlation EMD expression vsnCTC its clinical impact. Methods: We analyzed CTCs from 93 mCRPC patients...
Because of the potential increased incidence acute urinary retention, optimal timing catheter removal after major pelvic colorectal surgery remains unclear.This study aims to compare retention following early on postoperative day 1 vs standard 3.This is a randomized, noninferiority trial.This was conducted at an urban teaching hospital.Patients undergoing below peritoneal reflection were selected.A 1:1 randomization or performed. Patients in arm administered α-antagonist (prazosin mg oral) 6...
This secondary analysis of a randomized clinical trial examines the effect androgen deprivation therapy (ADT) during radiotherapy in patients who were classified as having either favorable intermediate-risk or unfavorable prostate cancer.
COVID-19 has disproportionately affected socially vulnerable communities characterized by lower income, education attainment, and higher proportions of minority populations, among other factors (1-4). Disparities in incidence the impact vaccination on disparities community income were assessed 81 Los Angeles, California. Median coverage calculated across household strata using a generalized linear mixed effects model with Poisson distribution during three surge periods: two before vaccine...
Optimizing outcomes in prostate cancer (PCa) requires precision characterization of disease status. This effort was directed at developing a PCa extracellular vesicle (EV) Digital Scoring Assay (DSA) for detecting metastasis and monitoring progression PCa. EV DSA is comprised an purification device (i.e., Click Chip) reverse-transcription droplet digital PCR that quantifies 11 PCa-relevant mRNA purified PCa-derived EVs. A Met score computed each plasma sample based on the expression 11-gene...
Scholarly activity is a requirement for accreditation by the Accreditation Council Graduate Medical Education. There currently no uniform definition used all Residency Review Committees (RRCs). A total of 6 27 RRCs have rubric or draft to evaluate scholarly activity.To develop and set rubrics be in program reduce subjectivity evaluation at level individual residency programs across RRCs.We performed review pertinent literature selected faculty promotion criteria United States structure...
Muscle sampling is often used as a surrogate for staging quality in patients with bladder cancer. The association of at diagnosis and survival was examined among
Accurate estimation of life expectancy is critical for men considering aggressive vs nonaggressive treatment early stage prostate cancer. We created an age adjusted comorbidity index that predicts other cause mortality in with cancer.We sampled 1,598 consecutively diagnosed cancer between 1998 and 2004 at West Los Angeles Long Beach Veterans Affairs hospitals. used competing risks regression testing validation cohorts to determine the risk nonprostate related (ie cause) associated diagnosis...
Progressive independence in patient care activities is imperative for residents' readiness practice and safety of those cared by graduates residency programs. However, establishing a standardized system progressive an ongoing challenge graduate medical education.We aggregated trainees' perspectives on independence, developed model the ideal state, suggested actionable improvements.A multispecialty, nationally representative group trainees conducted structured exercise that (1) described...