A5100668992- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Ureteral procedures and complications
- Cancer, Hypoxia, and Metabolism
- Urinary Bladder and Prostate Research
- Ferroptosis and cancer prognosis
- Renal and Vascular Pathologies
- CAR-T cell therapy research
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Enzyme function and inhibition
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
Cedars-Sinai Medical Center
2016-2025
University of California, Los Angeles
2003-2023
VA Greater Los Angeles Healthcare System
2011-2023
Jeonbuk National University
2022
Olive View-UCLA Medical Center
2021
University of Washington
2019
Hanyang University
2019
University of San Francisco
2018
European Research Council
2018
Kyung Hee University
2013-2018
You have accessJournal of UrologyTuesday, May 11, 2004, 1:00 - 3:00 pm1 Apr 20041653: Safety and Efficacy Partial Nephrectomy for all T1 Tumors Based on an International Multicenter Experience Jean-Jacques Patard, Oleg Shvarts, Allan J. Pantuck, Vincenzo Ficarra, Hyung L. Kim, Luca Cindolo, Ken Han, Alexandre De La Taille, Jacques Tostain, Walter Artibani, ClementClaude Abbou, Bernard Lobel, Dominique Chopin, Franfois Guille, Robert A. Figlin, Peter Mulders, Arie S. Belldegrun...
To evaluate ability of the University California Los Angeles Integrated Staging System (UISS) to stratify patients with localized and metastatic renal cell carcinoma (RCC) into risk groups in an international multicenter study.4,202 from eight academic centers were classified according UISS, which combines TNM stage, Fuhrman grade, Eastern Cooperative Oncology Group performance status. Distribution UISS categories was assessed overall population each center.The stratified both RCC three...
Epithelioid angiomyolipomas (perivascular epithelioid cell tumors) of the kidney are defined as potentially malignant mesenchymal lesions that closely related to classic angiomyolipoma. Although approximately 120 cases published, mostly case reports with variably used diagnostic criteria, pathologic prognostic predictors outcome unknown. We analyzed clinicopathologic parameters in a large series 41 pure kidney, which we designate (monotypic) PEComas contrast them from regarded by some...
Prostate cancer cells release atypically large extracellular vesicles (EVs), termed oncosomes, which may play a role in the tumor microenvironment by transporting bioactive molecules across tissue spaces and through blood stream. In this study, we applied novel method for selective isolation of oncosomes applicable to human platelet-poor plasma, where presence caveolin-1-positive identified patients with metastatic disease. This procedure was also used validate results miRNA array performed...
The prognostic significance of the level venous involvement in renal cell carcinoma (RCC) is controversial. It has been suggested that 1997 TNM classification system should be revised.The records 226 patients who underwent a nephrectomy and tumor thrombectomy, 117 for vein (RV) 109 inferior vena cava (IVC) involvement, between 1989 2001 were reviewed compared to those 654 undergoing without involvement.In with localized RCC (N0M0), risk recurrence after was significantly increased thrombus...
Abstract Purpose: An accurate system for predicting survival patients with solid tumors will allow better patient selection both established and novel therapies. We propose a staging clear cell variants of renal carcinoma (RCC) that includes molecular predictors standard clinical such as tumor-node-metastasis (TNM) stage, histological grade, performance status (PS). Experimental Design: A custom tissue array was constructed using RCC from 318 patients, representing all stages localized...
Abstract Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding its underlying genetic programs. There no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphologic classification PRCC into type 1 2 tumors has been recently proposed, but biological relevance remains uncertain. We studied gene expression profiles 34 cases using Affymetrix HGU133 Plus 2.0 arrays (54,675...
No AccessJournal of UrologyAdult Urology: Oncology: Renal/Upper Tract/Bladder1 May 2005USING TUMOR MARKERS TO PREDICT THE SURVIVAL OF PATIENTS WITH METASTATIC RENAL CELL CARCINOMA HYUNG L. KIM, DAVID SELIGSON, XUELI LIU, NICOLETTE JANZEN, MATTHEW H.T. BUI, HONG YU, TAO SHI, ARIE S. BELLDEGRUN, STEVE HORVATH, and ROBERT A. FIGLIN KIMHYUNG KIM Equal study contribution. More articles by this author , SELIGSONDAVID SELIGSON LIUXUELI LIU JANZENNICOLETTE JANZEN BUIMATTHEW BUI YUHONG YU SHITAO SHI...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Oct 2003Treatment Organ Confined Prostate Cancer with Third Generation Cryosurgery: Preliminary Multicenter Experience KEN-RYU HAN, JEFF K. COHEN, RALPH J. MILLER, ALLAN PANTUCK, DANIELO G. FREITAS, CARLOS A. CUEVAS, HYUNG L. KIM, JAMES LUGG, STACY CHILDS, BARRY SHUMAN, MAURY JAYSON, NEAL D. SHORE, YAN MOORE, AMNON ZISMAN, JOE Y. LEE, ROLAND UGARTE, LANCE MYNDERSE, TORRENCE M. WILSON, SUSAN SWEAT, HORST ZINCKE, and ARIE S....
Renal cell carcinoma (RCC) can present with a wide range of signs and symptoms. To our knowledge we report the first study to describe frequency paraneoplastic findings in modern RCC series assess prognostic significance each finding.Using kidney cancer database at institution 1,046 patients undergoing nephrectomy for between 1989 2001 were assessed. The symptoms diagnosis on preoperative laboratory evaluation examined univariate analysis as well multivariate controlling TNM stage, Fuhrman...
The natural history of renal cell carcinoma (RCC) is complex and not entirely explained by conventional prognostic factors. In this study we evaluated the value carbonic anhydrase IX (CAIX) Ki67 to predict survival in RCC.Immunohistochemical analysis using a CAIX monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens 224 patients treated with nephrectomy for clear carcinoma. staining were correlated clinical factors, pathological features...
Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does study add? For small renal tumours, partial nephrectomy provides excellent cancer control preserves function. The RENAL Nephrometry Score is useful for quantifying anatomic features relevant to surgical decision‐making. In patients undergoing laparoscopic nephrectomy, this shows a correlation between estimated blood loss, warm ischemia time, length hospital stay, suggesting that may be...
Sunitinib is an approved treatment for metastatic renal cell carcinoma. We performed a prospective clinical trial to evaluate the safety and response sunitinib administered before nephrectomy in patients with localized or clear carcinoma.Patients biopsy proven carcinoma were enrolled study treated 37.5 mg malate daily 3 months nephrectomy. The primary end point was safety.In 18-month period 20 enrolled. most common toxicities gastrointestinal symptoms hematological effects. Grade toxicity...
<h3>Importance</h3> Early postoperative ambulation is vital to minimizing length of stay (LOS), but few hospitals objectively measure predict outcomes. Wearable activity monitors have the potential transform assessment ambulation, key implementation data, including whether digitally monitored step count can identify patients at risk for poor efficiency outcomes, are lacking. <h3>Objectives</h3> To define distribution measured daily counts after major inpatient surgical procedures, assess...
Immunotherapy targeting CD4 + FoxP3 regulatory T cells (Tregs) through lymphocyte depletion is being investigated as cancer treatment. This study examines the efficacy and limitations of across various models. We examined in syngeneic mouse tumor models including B16 melanoma, Renca kidney cancer, Hepa1-6 hepatocellular carcinoma. The explored relationship between MHC II expression growth, immune response, survival. In models, suppressed growth but accelerated tumors. had high while other...
Summary Objectives We investigated the association between smoking and its additive effects with insulin resistance β‐cell function on incidence of type 2 diabetes in a prospective population‐based cohort study. Design method A total 10 038 subjects were recruited from rural urban areas. All underwent 75 g oral glucose tolerance tests full biochemical assessments at baseline during 4‐year follow‐up period. The final analysis was limited to 4041 men due low rates women. Results ex‐ heavy...
Positive surgical margins at radical cystectomy confer a poor prognosis. We evaluated the incidence and predictors of positive in patients who underwent robot assisted for bladder cancer.Using International Robotic Cystectomy Consortium database we identified 513 cystectomy, as done by total 22 surgeons 15 institutions from 2003 to 2009. After stratification age group, gender, pathological T stage, nodal status, sequential case number institutional volume logistic regression was used...
Temsirolimus is a mammalian target of rapamycin (mTOR) inhibitor and analogue that approved for treating advanced renal cell carcinoma (RCC). It being actively evaluated in clinical trials melanoma. The mTOR inhibitors are also immunosuppressants used clinically to prevent rejection following solid-organ transplant. Novel immunotherapies developed immunoresponsive tumours, such as RCC Immune-modulating effects temsirolimus were characterised when combination with cancer vaccines targeting...