A5071434634- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Ureteral procedures and complications
- Prostate Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Urinary and Genital Oncology Studies
- Pediatric Urology and Nephrology Studies
- Testicular diseases and treatments
- Advancements in Semiconductor Devices and Circuit Design
- Pancreatic and Hepatic Oncology Research
- Semiconductor materials and devices
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Adrenal and Paraganglionic Tumors
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
Tokushima University
2015-2025
Tokushima University Hospital
2023
Japanese Urological Association
2017-2021
Institute of Biomedical Science
2019-2020
Tokushima Municipal Hospital
2018
NTT (Japan)
1992-2017
Hiraka General Hospital
2017
Hokkaido University
2009
Van Andel Institute
2002-2007
Cancer Genetics (United States)
2002-2007
To better understand the molecular mechanisms that underlie tumorigenesis and progression of clear cell renal carcinoma (ccRCC), we studied gene expression profiles 29 ccRCC tumors obtained from patients with diverse clinical outcomes by using 21,632 cDNA microarrays. We identified alterations were both common to most unique subsets. There was a significant distinction in profile between relatively nonaggressive form disease [100% survival after 5 years majority (15/17 or 88%) having no...
Abstract Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding its underlying genetic programs. There no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphologic classification PRCC into type 1 2 tumors has been recently proposed, but biological relevance remains uncertain. We studied gene expression profiles 34 cases using Affymetrix HGU133 Plus 2.0 arrays (54,675...
Alpha-methylacyl-CoA racemase (AMACR) was first discovered by using cDNA microarray technology as a molecular marker for prostate cancer. Our recent analysis of renal cell carcinomas showed significant increase AMACR mRNA levels in papillary carcinomas, but not other subtypes. To investigate the value this pathologic diagnosis, we analyzed microarrays from 70 kidney tumors. Furthermore, evaluated expression 165 tumors on tissue and 51 organs immunohistochemistry. significantly overexpressed...
This study aims to assess the efficacy and safety of sunitinib in Japanese patients with metastatic renal cell carcinoma (RCC).Fifty-one prior nephrectomy, 25 treatment-naive (first-line group) 26 cytokine-refractory (pretreated were enrolled this phase II trial. Patients received 50 mg orally, once daily, repeated 6-week cycles (4 weeks on treatment, 2 off). The primary endpoint was RECIST-defined objective response rate (ORR) tumour assessments every 6 via computed tomography or magnetic...
Abstract Background The docking‐free design of the Japanese Hinotori surgical robotic system allows arm to avoid trocar grasping, thereby minimising excessive abdominal wall stress. aim this study was evaluate safety and efficacy robotic‐assisted radical prostatectomy (RARP) using explore potential contribution its postoperative pain reduction. Methods This reviewed clinical records 94 patients who underwent RARP: 48 in group 46 da Vinci Xi group. Results had significantly longer operative...
BackgroundIn a phase II, open-label, multicentre Japanese study, sunitinib demonstrated antitumour activity and acceptable tolerability in metastatic renal cell carcinoma patients. Final survival analyses updated results are reported.
Abstract Renal cell carcinoma (RCC) is a heterogeneous disease that includes several histologically distinct subtypes. The most common RCC subtypes are clear cell, papillary, and chromophobe, recent gene expression profiling studies suggest classification of based on transcriptional signatures could be beneficial. Traditionally, however, patterns chromosomal alterations have been used to assist in the molecular RCC. purpose this study was determine whether it possible develop model for three...
Abstract Parathyroid tumors are heterogeneous, and diagnosis is often difficult using histologic clinical features. We have undertaken expression profiling of 53 hereditary sporadic parathyroid to better define the molecular genetics tumors. A class discovery approach identified three distinct groups: (1) predominantly hyperplasia cluster, (2) HRPT2/carcinoma cluster consisting carcinomas benign malignant from Hyperparathyroidism-Jaw Tumor Syndrome patients, (3) adenoma mainly primary MEN 1...
The efficacy and safety of nivolumab plus ipilimumab (NIVO + IPI) for elderly patients with metastatic renal cell carcinoma have not been reported sufficient evidence. Our study therefore aimed to compare the NIVO IPI between ≥75 years <75 carcinoma. We retrospectively analyzed a multi-center cohort 156 that received treatment at eight institutions. Among them, 33 were old, remainder old. Patient demographics tumor characteristics significantly different two groups except age. objective...
ABSTRACT Objective Malnutrition is a common condition among elderly cancer patients. The Geriatric Nutritional Risk Index (GNRI) simple screening tool used to predict the risk of postoperative complications in patients undergoing radical cystectomy. This study aimed evaluate effectiveness preoperative GNRI as marker for predicting 90‐day robot‐assisted cystectomy (RARC). Methods We retrospectively evaluated 385 who underwent RARC at four affiliated institutes Tokushima University between...
PURPOSE Anti–PD-1 antibodies are widely used for cancer treatment, including in advanced renal cell carcinoma (RCC). However, the therapeutic response varies among patients. This study aimed to predict tumor nivolumab anti–PD-1 antibody treatment RCC by integrating genetic and clinical data using machine learning (ML). METHODS Clinical single-nucleotide polymorphism (SNP) obtained SNPs PD-1 inhibitor study, which enrolled Japanese patients treated with monotherapy clear RCC, were used. A...
<i>Background:</i> Vascular endothelial growth factor (VEGF) and its receptors are major regulators of cancer cell metastases. We investigated the association between serum VEGF levels clinicopathological parameters in bladder patients. also evaluated effects receptor inhibitor on proliferation invasion lines. <i>Methods:</i> Serum were measured 52 patients with 45 healthy controls. In highly invasive lines (T-24, UMUC-3 J82), we assessed effect The (VEGFR) tyrosine...
Abstract Objective Lung immune prognostic index is based on derived neutrophil-to-lymphocyte ratio and lactate dehydrogenase level. has reported association with survival outcomes in patients various malignancies undergoing treatment checkpoint inhibitors. However, the impact of pre-treatment lung metastatic renal cell carcinoma receiving nivolumab plus ipilimumab remains unclear. This study examines between this setting. Methods We retrospectively evaluated 156 treated at eight...
To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear renal carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate prognostic value for patient outcome, determine effect PSCA on progression CC-RCC.We quantified mRNA RCC lines (ACHN, A704, KPK-1, Caki-1, Caki-2) 154 surgical tissue samples (81 from CC-RCC, 73 normal kidney) using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The...
To better understand the molecular mechanisms that underlay development and progression of nonseminomatous germ cell tumor testis (NSGCTT) as well malignant transformation teratoma primitive neuroectodermal (PNET).We studied gene expression profiles 17 retroperitoneal NSGCTTs (10 yolk sac tumors, 3 embryonal carcinomas, 4 teratomas) 2 PNETs obtained from patients with two clinical outcomes. Tissue samples were Indiana University. One group NSGCTT PNET developed metastases within years...
Although the percentage of patients with renal cell carcinoma (RCC) extending into venous systems is unexpectedly high, prognostic impact and independency tumor thrombus-related factors on overall survival (OS) remain controversial. Furthermore, various clinicopathologic including OS may change elapsed years after intervention also follow-up duration participants. The aim study to explore independent universal predictive preoperative intraoperative in RCC using subgroup analysis terms...
Clear cell renal carcinoma (ccRCC) has been previously classified into putative discrete prognostic subtypes by gene expression profiling. To investigate the robustness of these proposed subtype classifications, we evaluated 12 public datasets, together with a new dataset 265 ccRCC profiles. Consensus clustering showed unstable and principal component analysis (PCA) continuous spectrum both within between datasets. Considering lack delineation observed, developed quantitative prognosis score...
<b><i>Background:</i></b> The flexible ureterorenoscope (URS) and associated devices have developed rapidly. However, despite its therapeutic benefits, URS may be with some complications. To the best of our knowledge, there are no studies discussing complications flexURS during learning curve. <b><i>Methods:</i></b> A retrospective review records patients who underwent from January 2005 to June 2013 was performed. compare after introduction...