A5048923727- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Tuberous Sclerosis Complex Research
- Liver Diseases and Immunity
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Urology and Nephrology Studies
- Ovarian cancer diagnosis and treatment
- Chronic Kidney Disease and Diabetes
- Advanced X-ray and CT Imaging
- Metastasis and carcinoma case studies
Tokyo Medical and Dental University
2015-2025
Institute of Science Tokyo
2024-2025
The University of Tokyo
2024
Cleveland Clinic
2017-2022
Japanese Foundation For Cancer Research
2012-2021
First Hospital of Jilin University
2021
Jilin University
2021
Ritsumeikan University
2021
Niigata Cancer Center Hospital
2021
Asahi General Hospital
2021
Background C‐reactive protein (CRP) is a prognostic biomarker for clear cell renal carcinoma (ccRCC). However, there may be potential racial heterogeneity in distribution and impact of CRP level. We investigated differences preoperative among Asian (AS), African American (AA), Caucasian (CAUC) patients with non‐metastatic ccRCC (nmccRCC). Methods retrospectively analyzed 1991 nmccRCC cases (AS/AA/CAUC: n = 968/223/800) undergoing nephrectomy from the international multi‐institutional...
Background The effectiveness of immune checkpoint inhibitors (ICIs) as adjuvant therapy for muscle-invasive urothelial carcinoma (MIUC) with high recurrence risk has been demonstrated. With no direct efficacy comparisons available, we aimed to indirectly compare the and safety pembrolizumab, nivolumab, atezolizumab treatments high-risk MIUC based on individual patient data (IPD) from clinical trials. Methods IPD was reconstructed using Shiny method Kaplan–Meier curves eligible randomized...
This study aimed to assess the treatment preferences of Japanese patients with muscle-invasive bladder cancer (MIBC) by quantifying their trade-offs between attributes using a discrete choice experiment (DCE). A DCE was conducted among MIBC post-radical cystectomy. Participants were presented hypothetical options differing in such as efficacy Disease-free survival (DFS), side effects, administration, and cost. Preference data analyzed determine each attribute's relative importance (RI),...
Transpapillary bile duct brushing cytology and/or forceps biopsy was performed in the presence of an indwelling guidewire patients with biliary stricture, and treatment time, overall diagnosis rate, rate each disease, complications, influences on subsequent drainage were investigated.After endoscopic retrograde cholangiography, performed, followed by biopsy. In obstructive jaundice, (EBD) subsequently performed. To investigate EBD, who underwent EBD plastic stent compared alone.The samples...
Renal cell carcinoma (RCC) is a common cancer that increasing in incidence because of the increased prevalence risk factors, including tobacco use, hypertension, and obesity, improved detection these tumors due to use imaging. Localized renal now accounts for more than 60%-70% new RCC cases. masses suggestive include enhancing solid lesions Bosniak III IV complex cystic lesions. Most are detected incidentally, many slow growing with little propensity metastasize. Radiologists have vital role...
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine human autoimmunity, anti-mitochondrial (AMA). However, therapeutic advances this disease have lagged behind. Herein we taken advantage of our unique PBC which mice immunized 2-octynoic acid coupled to BSA (2OA-BSA), compound identified by quantitative structure activity relationships (QSAR) AMA binding, develop an intense inflammatory cholangitis...
This study aimed to assess the prognostic outcomes in mRCC patients receiving second-line TKI following first-line IO combination therapy.
A radioimmunoassay (RIA) test for human pancreatic cancer-associated antigen (Span-1) was developed to evaluate the diagnosis of various gastrointestinal disorders. Serum Span-1 in normal subjects ranged from 5 275 U/ml, with a mean 58.8 U/ml (±58.7, standard deviation). All control had levels less than 400 U/ml. Study subjects, 93% cancer, 59% hepatobiliary cancers, 23% gastric and 13% colonic cancers serum greater Sensitivities Span-1, CA 19-9, Dupan-2 cancer were 94%, 85%, 38%...
To clarify the frequency and clinical significance of extrapancreatic lesions in autoimmune pancreatitis (AIP).The characteristics during course AIP were investigated retrospectively 64 patients with AIP. The predictive factors for relapse at onset also examined.Extrapancreatic occurred 95% (61/64) frequencies sclerosing cholangitis, sialadenitis, retroperitoneal fibrosis, mediastinal or hilar lymphadenopathy 84% (54/64), 23% (15/64), 16% (10/64), 77% (27/35), respectively. Patients...
The aim of the present study was to evaluate diffusion-weighted (DW) magnetic resonance imaging (MRI) in differentiating between minimal fat angiomyolipoma (MFAML) and clear cell renal carcinoma (CCRCC). Forty-one solid tumors without visible macroscopic on unenhanced computed tomography images were evaluated by MRI, including DW-MRI, diagnosed pathologically as CCRCC (n = 36) or MFAML 5). To heterogeneity diffusion each tumor, signals DW-MRI analyzed subjectively apparent coefficient (ADC)...
Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions, and the concept of IgG4-related autoimmune disease has been proposed. We report a 62-year-old woman AIP various lesions during long-term clinical course. These occurred after withdrawal steroid therapy. Sclerosing sialadenitis before AIP, whereas sensorineural hearing loss, allergic purpura endocapillary proliferative glomerulonephritis AIP. However, no relapse was observed for 5 years start maintenance...
Novel biomarkers for pancreatic ductal adenocarcinoma (PDAC) are urgently needed because of its poor prognosis. We have previously established an animal model human PDAC using transgenic rats in which expression a K-ras(G12V) oncogene is regulated by the Cre/lox system. Using this model, we searched candidate circulating microRNAs (miRNAs) use as novel clinical diagnostic PDAC.Rats bearing PDACs were generated our model. MicroRNA serum and tissues control was compared microarray analysis....
Treatment of primary biliary cirrhosis (PBC) has lagged behind that other autoimmune diseases. In this study we have addressed the potential utility immunotherapy using regulatory T cells (Treg ) to treat murine cholangitis. particular, taken advantage our ability produce portal inflammation and bile duct cell loss by transfer CD8(+) from dominant negative form transforming growth factor beta receptor type II (dnTGF-βRII) mice recombination-activating gene (Rag)1(-/-) recipients. We then...
To evaluate the oncological and functional outcomes associated with selective tetramodal bladder-sparing therapy, comprising maximal transurethral resection of bladder tumour (TURBT), induction chemoradiotherapy (CRT), consolidative partial cystectomy (PC) pelvic lymph node dissection (PLND).In present study, 154 patients non-metastatic muscle-invasive cancer (MIBC), prospectively enrolled in bladder-preservation protocol, were analysed. After TURBT CRT, showing complete remission offered PC...
There are several murine models described with features similar to human primary biliary cirrhosis (PBC). Among these models, the one which has closest serologic PBC is a mouse T-cell-restricted expression of dominant negative transforming growth factor β receptor type II (dnTGFβRII). Our work demonstrated that CD8 + T cells from dnTGFβRII mice transfer autoimmune cholangitis Rag1 −/− recipients. However, it remained unclear whether was secondary an intrinsic function within or due abnormal...
While there have been significant advances in our understanding of the autoimmune responses and molecular nature target autoantigens primary biliary cirrhosis (PBC), unfortunately these data yet to be translated into new therapeutic agents. We taken advantage a unique murine model cholangitis which mice expressing dominant negative form transforming growth factor β receptor II (dnTGFβRII), under control CD4 promoter, develop an intense associated with serological features similar human PBC....
To determine the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting metastasis and its impact on patient management with upper tract urothelial carcinoma (UTUC).Consecutive patients UTUC underwent 18F-FDG PET/CT after CT initial staging (n = 47) restaging at recurrence 9). Diagnostic metastases was compared statistically. The assessed by comparing questionnaires that were completed attending physicians before...
To evaluate the utility of parenchymal volume analysis (PVA) for estimation split renal function (SRF) in patients with masses. SRF is important deciding about partial vs radical nephrectomy (PN/RN) and assessing risk developing severe chronic kidney disease after surgery. For donors PVA routinely used to estimate SRF, but more complex mass population remains undefined.All (n = 374) tumours a normal contralateral managed PN (2010-2018), preoperative/postoperative nuclear scans (NRS)...
Loss of renal function remains a major limitation radical nephrectomy. The extent functional compensation by the preserved kidney after nephrectomy has not been adequately studied in this elderly population with comorbidities.A total 273 patients treated without end stage disease available preoperative nuclear scans were included analysis. Renal was defined as percent change estimated glomerular filtration rate Estimated calculated Chronic Kidney Disease-Epidemiology Collaboration formula up...