A5065047534- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Mast cells and histamine
- IgG4-Related and Inflammatory Diseases
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- RNA and protein synthesis mechanisms
- Dermatology and Skin Diseases
- Esophageal and GI Pathology
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- Neuroendocrine Tumor Research Advances
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
Juntendo University
2017-2025
Kumamoto City Hospital
2014-2024
La Jolla Institute for Immunology
2009-2023
RIKEN Center for Integrative Medical Sciences
2013-2019
National Institute of Diabetes and Digestive and Kidney Diseases
2018
ProQuest (United States)
2018
The University of Tokyo
2014-2015
Nagoya City University
2002-2011
Louisiana State University Health Sciences Center Shreveport
2005-2010
Mizuho (Japan)
2002-2010
ABSTRACT Background IgE‐mediated food allergy is accompanied by mucosal mast cell (MMC) hyperplasia in the intestinal mucosa. Intestinal MMC numbers correlate with severity of symptoms. However, mechanisms which MMCs proliferate excessively are poorly understood. Here, we clarify role newly identified MHC class II (MHCII)‐expressing effector phase allergy. Methods Mice reconstituted MHCII‐deficient or wild‐type were used to generate a mouse mode We assessed extent and hypothermia these mice....
Abstract Background and Aim: The extent of liver drainage for palliative treatment malignant hilar biliary obstruction is controversial. aim this study was to compare endoscopic unilateral versus bilateral in patients with using a self‐expanding metal stent (SEMS). Methods: We carried out retrospective review 46 consecutive who were treated by SEMS between 1997 2005. Unilateral stenting (group A) performed 17 2000, B) 29 2001 successful insertion, drainage, early complications, late patency,...
Although a major effect of p21, cyclin-dependent kinase inhibitor, is considered to be exerted during G(1) phase the cell cycle, p21 gene knock-out studies suggested its involvement in G(2)/M checkpoint as well. Here we demonstrate evidence that required for cycle arrest at G(2) upon DNA damage. We found expression wild-type (p21(WT)), not mutant (p21(PCNA-)) lacking interaction with proliferating nuclear antigen (PCNA), caused p53-deficient DLD1 colon cancer line after damage by treatment...
Sclerosing cholangitis (SC) with autoimmune pancreatitis (AIP) is similar to primary sclerosing (PSC) regard cholangiographic findings, but only the former responds well steroid therapy. This report concentrates on clinical differences between these diseases.The presenting complaint or abnormality, associated disease, pancreatic changes, treatment, and course were studied for several cases of PSC (n = 27) SC AIP 20).SC as a diagnosis occurs abruptly obstructive jaundice compared where often...
Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions. We studied 31 cases of AIP to clarify the diversity lesions and differences between without lesions.The clinical features courses were compared by age, sex, blood chemistry those In addition, we reviewed available literature on AIP.Seven had lesions, which diagnosed simultaneously AIP; however, 1 case presenting various was independently lesion. Patients needed maintenance steroid therapy for in 4 2...
Transpapillary bile duct brushing cytology and/or forceps biopsy was performed in the presence of an indwelling guidewire patients with biliary stricture, and treatment time, overall diagnosis rate, rate each disease, complications, influences on subsequent drainage were investigated.After endoscopic retrograde cholangiography, performed, followed by biopsy. In obstructive jaundice, (EBD) subsequently performed. To investigate EBD, who underwent EBD plastic stent compared alone.The samples...
Only a few studies have documented the characteristics of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC). We aimed to clarify clinical and histopathological IBD PSC (PSC-IBD).Twenty-nine patients 60 ulcerative colitis (UC) but without complicating were enrolled in this study. First, age sex distribution, affected area, course, number recurrent attacks, severity UC investigated. Then, mucosal specimens obtained from right side (cecum ascending colon),...
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like lesions and more severe allergen-induced than wild-type mice. Mast cells were required for both AD models remarkably increased in the of Plcb3−/− because Stat5 reduced SHP-1 activities. cell-specific deletion gene ameliorated dermatitis, whereas Shp1 encoding Stat5-inactivating exacerbated it. PLC-β3 regulates expression periostin...
Abstract Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human mouse cell Alcian blue-detectable sialic acids, but not sulfates steady state. Interestingly, Balb/c strain lacks this sialylation due to a point mutation sialyltransferase gene, St6galnac1 , which is responsible for sialyl-Tn synthesis. Introduction intact restores mucus....
To clarify the frequency and clinical significance of extrapancreatic lesions in autoimmune pancreatitis (AIP).The characteristics during course AIP were investigated retrospectively 64 patients with AIP. The predictive factors for relapse at onset also examined.Extrapancreatic occurred 95% (61/64) frequencies sclerosing cholangitis, sialadenitis, retroperitoneal fibrosis, mediastinal or hilar lymphadenopathy 84% (54/64), 23% (15/64), 16% (10/64), 77% (27/35), respectively. Patients...
Threats of bioterrorism have renewed efforts to better understand poxvirus pathogenesis and develop a safer vaccine against smallpox. Individuals with atopic dermatitis are excluded from smallpox vaccination because their propensity eczema vaccinatum, disseminated vaccinia virus (VACV) infection. To study the underlying mechanism vulnerability patients VACV infection, we developed mouse model vaccinatum. Virus infection eczematous skin induced severe primary erosive lesions, but not in...
IgE-mediated activation of mast cells and basophils underlies allergic diseases such as asthma. Histamine-releasing factor (HRF; also known translationally controlled tumor protein [TCTP] fortilin) has been implicated in late-phase reactions (LPRs) chronic inflammation, but its functions during asthma are not well understood. Here, we identified a subset IgE IgG antibodies HRF-interacting molecules vitro. HRF was able to dimerize bind Igs via interactions N-terminal internal regions with the...
Background Patients with food allergy often suffer from atopic dermatitis, in which Staphylococcus aureus colonization is frequently observed. δ-toxin activates mast cells and promotes T helper 2 type skin inflammation the tape-stripped murine skin. However, physiological effects of present on steady-state remain unknown. We aimed to investigate whether impacts development allergy. Material methods The non-tape-stripped skins wild-type, Kit W-sh/W-sh , or ST2-deficient mice were treated...
Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions, and the concept of IgG4-related autoimmune disease has been proposed. We report a 62-year-old woman AIP various lesions during long-term clinical course. These occurred after withdrawal steroid therapy. Sclerosing sialadenitis before AIP, whereas sensorineural hearing loss, allergic purpura endocapillary proliferative glomerulonephritis AIP. However, no relapse was observed for 5 years start maintenance...
Inflammatory cytokines dysregulate microvascular function, yet how affect lymphatic endothelial cells (LEC) are unclear.We examined effects of TNF-α, IL-1 beta, and IFN-gamma on LEC proliferation, cell adhesion molecule (ECAM) expression, capillary formation, barrier changes in murine (SV-LEC) human LECs (HMEC-1a).All induced ICAM-1, VCAM-1, MAdCAM-1, E-selectin SV-LECs; beta; ECAMs (but not MAdCAM-1) HMEC-1a. beta increased, while TNF-α reduced SV-LEC proliferation. While induced,...
In the present study, we evaluated effects of kaempferol on bone marrow-derived mast cells (BMMCs). Kaempferol treatment significantly and dose-dependently inhibited IgE-induced degranulation, cytokine production BMMCs under condition that cell viability was maintained. downregulated surface expression levels FcεRI BMMCs, but mRNA FcεRIα, β, γ-chains were not changed by treatment. Furthermore, kaempferol-mediated downregulation still observed when protein synthesis or transporter inhibited....