A5101606337- Helicobacter pylori-related gastroenterology studies
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Research on Leishmaniasis Studies
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Nitric Oxide and Endothelin Effects
- Gallbladder and Bile Duct Disorders
- Parasite Biology and Host Interactions
- Pancreatic and Hepatic Oncology Research
- Cardiac Imaging and Diagnostics
- Trypanosoma species research and implications
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Meat and Animal Product Quality
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Insects and Parasite Interactions
- Coronary Interventions and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Cell Adhesion Molecules Research
- Gastroesophageal reflux and treatments
University of Tsukuba
2010-2025
Aichi Medical University
2014-2024
Kindai University Hospital
2020-2024
Yamaguchi Prefecture Central Hospital
1999-2017
Aichi Cancer Center
2017
University of Tokyo Hospital
2016
University of Electro-Communications
2015
North Carolina State University
2014
Kariya Toyota General Hospital
2006-2014
Itochu (Japan)
2012
Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on mortality and ventilator-free days have not been well studied among with sepsis.To examine whether a strategy dexmedetomidine can improve clinical outcomes in sepsis ventilation.Open-label, multicenter randomized trial conducted at 8 intensive care units Japan from February 2013 until January 2016 201 consecutive adult requiring mechanical ventilation least 24 hours.Patients were to receive either...
Although a major effect of p21, cyclin-dependent kinase inhibitor, is considered to be exerted during G(1) phase the cell cycle, p21 gene knock-out studies suggested its involvement in G(2)/M checkpoint as well. Here we demonstrate evidence that required for cycle arrest at G(2) upon DNA damage. We found expression wild-type (p21(WT)), not mutant (p21(PCNA-)) lacking interaction with proliferating nuclear antigen (PCNA), caused p53-deficient DLD1 colon cancer line after damage by treatment...
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when prevalence levels decreased a that MDA can be discontinued without threat recrudescence. six-country study was conducted assessing performance seven tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community...
In Brief We have reported that increased glutamate concentrations in microdialysate of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms neurotoxicity intrathecal tetracaine. However, little is known about whether this true for other local anesthetics. study, we compared effects anesthetics on CSF and neurologic histopathologic outcome. Rabbits were assigned into 5 groups (n = 6 each) intrathecally received 0.3 mL NaCl solution (control), 2% tetracaine, 10%...
The IkappaB kinase (IKK)-related NAK (also known as TBK or T2K) contributes to the activation of NF-kappaB-dependent gene expression. Here we identify NAP1 (for NAK-associated protein 1), a that interacts with and its relative IKK epsilon IKKi). activates facilitates oligomerization. Interestingly, NAK-NAP1 complex itself effectively phosphorylated serine 536 p65/RelA subunit NF-kappaB, this activity was stimulated by tumor necrosis factor alpha (TNF-alpha). Overexpression specifically...
In this study, we have demonstrated that translocated in liposarcoma (TLS), also termed FUS, is an interacting molecule of the p65 (RelA) subunit transcription factor nuclear kappaB (NF-kappaB) using a yeast two-hybrid screen. We confirmed interaction between TLS and by pull-down assay vitro coimmunoprecipitation experiment followed Western blot cultured cell vivo. was originally identified as part fusion protein with CHOP arising from chromosomal translocation human myxoid liposarcomas. has...
Pigmentation in avian eggshells appears to be associated with shell strength, temperature regulation, and camouflage. The pigments found are mainly porphyrins, which have been utilized therapeutically as photosensitizers. Here, we examined the photoinactivation of gram-positive (Staphylococcus aureus, Bacillus cereus) gram-negative bacteria (Escherichia coli, Salmonella enteritidis) by hen their pigments. results indicated that a light-dependent antimicrobial activity against gram-positive,...
Aims : Autoimmune pancreatitis (AIP), characterized by raised serum IgG4 levels, is frequently complicated disorders of extrapancreatic organs. The aim the present study was to examine immunohistochemically which organs are affected, and whether an autoantibody such in AIP patients. Methods Various tissues/organs obtained from patients were studied with anti‐IgG4 antibody. To presence patients, sera incubated various normal organs/tissues extracted for other diseases, followed detection Sera...
Phosvitin, a phosphoprotein known as an iron-carrier in egg yolk, binds almost all the yolk iron. In this study, we investigated effect of phosvitin on Fe(II)-catalyzed hydroxyl radical (•OH) formation from H2O2 Fenton reaction system. Using electron spin resonance (ESR) with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and deoxyribose degradation assays, observed by both assays that more effectively inhibited •OH than iron-binding proteins such ferritin transferrin. The effectiveness was related...
ABSTRACT Background. Gastric atrophy induced by Helicobacter pylori is thought to predispose patients noncardiac gastric cancer development. However, the host genetic factors that influence progression of have not been elucidated. In this study, we examined effects cytokine polymorphisms on H. ‐induced atrophy. Methods. Blood samples were taken from 454 Japanese subjects. The interleukin‐2 (IL‐2; T‐330G), IL‐4 (C‐33T), and IL‐13 (C‐1111T) genotyped polymerase chain reaction with confronting...
Epidemiological and animal model studies have suggested that high intake of heme, present in red meat, is associated with an increased risk colon cancer. However, the mechanisms underlying this association are not clear. This study aimed to investigate whether heme induces DNA damage cell proliferation colonic epithelial cells via hydrogen peroxide produced by oxygenase (HO). We examined effects zinc protoporphyrin (ZnPP; a HO inhibitor) catalase on damage, proliferation, IL-8 production...