A5032982262- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Renal and Vascular Pathologies
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Organ Donation and Transplantation
- Gut microbiota and health
- Nutrition and Health in Aging
- Advances in Oncology and Radiotherapy
- Stoma care and complications
- Pelvic floor disorders treatments
- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Abdominal Surgery and Complications
Cleveland Clinic
2012-2025
Ohio Gastroenterology and Liver Institute
2023
Metro Health Hospital
2016-2017
Queen Elizabeth University Hospital
2016-2017
Case Western Reserve University
2017
University School
2017
University Hospitals of Cleveland
2017
MetroHealth Medical Center
2017
MetroHealth
2016
King's College Hospital
2013-2014
Clinical observations and epidemiologic studies suggest that the incidence of head neck squamous cell carcinoma (HNSCC) correlates with dental hygiene, implying a role for bacteria-induced inflammation in its pathogenesis. Here we begin to explore pilot hypothesis specific microbial populations may contribute HNSCC pathogenesis via epigenetic modifications inflammatory- HNSCC-associated genes. Microbiomic profiling by 16S rRNA sequencing matched tumor adjacent normal tissue specimens 42...
Preoperative estimation of new baseline glomerular filtration rate after partial nephrectomy or radical for renal cell carcinoma has important clinical implications. However, current predictive models are either complex lack external validity. We aimed to develop and validate a simple equation estimate postoperative rate.For development internal validation the equation, cohort 7,860 patients with undergoing nephrectomy/radical (2005-2015) at Veterans Affairs National Health System was...
To provide a more rigorous assessment of factors affecting functional recovery after partial nephrectomy (PN) using novel tools that allow for analysis patients and improved accuracy parenchymal volume loss, thereby revealing the potential impact secondary such as ischaemia.Of 1140 managed with PN (2012-2014), 670 (59%) had imaging serum creatinine levels measured before necessary inclusion. Recovery from ischaemia was defined ipsilateral glomerular filtration rate (GFR) saved normalised by...
Objective To rigorously evaluate the impact of percentage parenchymal volume preserved (PPVP) and how well parenchyma recovers from ischaemia (Rec ) on functional outcomes after partial nephrectomy (PN) using an accurate objective software‐based methodology for estimating volumes split renal function (SRF). A secondary was to assess potential predictors PPVP. Patients Methods total 894 PN patients with available studies (2011–2014) were evaluated. The PPVP measured cross‐sectional imaging at...
The precision of excision and reconstruction to optimize vascularized parenchymal preservation is a major determinant renal function after partial nephrectomy. We assessed nephrectomy surgical using volumetric computerized tomography analyzed predictive factors.We the records 122 patients treated with in whom detailed analysis specific operated kidney could be performed. used measure functional volume before kidney. glomerular filtration rate was determined by MDRD2 (Modification Diet Renal...
Poorly functioning kidneys may not recover from ischemia as well strongly kidneys. This could impact surgical approaches to partial nephrectomy.We analyzed the records of 155 consecutive patients treated with nephrectomy who underwent appropriate studies facilitate analysis function and parenchymal mass in operated kidney, including computerized tomography glomerular filtration rate measurement within 2 months preoperatively 4 12 postoperatively. Patients a contralateral kidney also renal...
Abstract We have produced antibodies to the NRG2‐alpha, NRG2‐beta, NRG3 and NRG4 proteins used these, previously described NRG1‐alpha NRG1‐beta, detect expression of each ligand by immunocytochemical staining in a series 45 breast cancers. Each protein was expressed proportion cases. Statistical analysis suggested that one factor associated with high probability other members family were co‐expressed. NRG2‐alpha node positivity ( p ‐value = 0.005). The mRNAs for NRG1, 2, 3 4 found...
To evaluate the utility of parenchymal volume analysis (PVA) for estimation split renal function (SRF) in patients with masses. SRF is important deciding about partial vs radical nephrectomy (PN/RN) and assessing risk developing severe chronic kidney disease after surgery. For donors PVA routinely used to estimate SRF, but more complex mass population remains undefined.All (n = 374) tumours a normal contralateral managed PN (2010-2018), preoperative/postoperative nuclear scans (NRS)...
Abstract We recently identified germline methylation of KILLIN , a novel p53‐regulated tumor suppressor proximal to PTEN in >1/3 Cowden or syndrome‐like (CS/CSL) individuals who are mutation negative. Individuals with had increased risks renal cell carcinoma (RCC) over those mutations. Therefore, we tested the hypothesis that may be RCC susceptibility gene, silenced by methylation. found hypermethylation combined bisulfite restriction analysis at least one four CpG‐rich regions 23/41...
560 Background: In the era of precision medicine, we pursue less invasive, more powerful methods for screening, response prediction, and recurrence detection. While liquid biopsy has proven useful in other malignancies, similar diagnostic prognostic tools renal cell carcinoma (RCC) remain to be elucidated. We therefore aimed investigate serum protein expression patients before their RCC diagnosis vs. non-cancer controls identify protein-cancer associations likely have a role cancer...