A5003018788- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
- Polymer Nanocomposites and Properties
- Polymer crystallization and properties
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- biodegradable polymer synthesis and properties
- Synthesis and properties of polymers
- Microbial Community Ecology and Physiology
- Chromatography in Natural Products
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Plant-based Medicinal Research
- Medicinal Plant Pharmacodynamics Research
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Liquid Crystal Research Advancements
- T-cell and B-cell Immunology
- Electrospun Nanofibers in Biomedical Applications
- Metabolomics and Mass Spectrometry Studies
- Grouting, Rheology, and Soil Mechanics
- Genomics and Phylogenetic Studies
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Studies
First Hospital of Jiaxing
2018-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Hangzhou Medical College
2025
Harbin Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2015-2025
Cedars-Sinai Medical Center
2014-2025
Shanghai Sixth People's Hospital
2025
ABSTRACT The recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV) continues to infect humans, with high mortality. Specific, highly effective therapeutics and vaccines against the MERS-CoV are urgently needed save human lives address pandemic concerns. We identified three monoclonal antibodies (MAbs), m336, m337, m338, targeting receptor (CD26/DPP4) binding domain (RBD) of spike glycoprotein from a very large naïve-antibody library (containing ∼10 11 antibodies). They...
A neutralizing human monoclonal antibody can fully protect nonhuman primates from disease after a lethal Hendra virus challenge.
Abstract The MERS-CoV is an emerging virus, which already infected more than 1,300 humans with high (∼36%) mortality. Here, we show that m336, exceptionally potent human anti-MERS-CoV antibody, almost germline only one somatic mutation in the heavy chain. structure of Fab m336 complex receptor-binding domain reveals its IGHV1-69-derived chain provides 85% binding surface and epitope completely overlaps site. Analysis antibodies from 69 healthy suggests important role V(D)J...
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent limit the disease. We examined in vivo efficacy monoclonal antibody m336, which has high neutralizing activity against MERS-CoV vitro. m336 was administered rabbits intravenously or intranasally before infection MERS-CoV. Prophylaxis resulted reduction pulmonary viral RNA titers by 40–9000-fold,...
Oligosaccharides are the main components of <italic>C. pilosula</italic> and show excellent immunomodulatory activities.
A large proportion (40-60%) of patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer do not benefit from trastuzumab treatment, potentially due to the lack complement-dependent cytotoxicity (CDC) activation. In present study, effect complement decay-accelerating (CD55) and CD59 glycoprotein precursor (CD59) expression on trastuzumab-induced CDC in HER2-positive cell lines was investigated. The CD55 CD59-overexpressing SK-BR-3 BT474 were selected for...
Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures (MCM) are available to combat MERS-CoV infections. Several neutralizing human monoclonal antibodies (mAbs), including m336, a germline-like mAb, have been chosen as promising MCM for MERS-CoV. However, their clinical development hindered by lack of robust animal model that recapitulate morbidity and mortality We assessed...
Abstract Background: While a potential connection between epilepsy and frailty has been proposed in past research, the causal nature of this relationship requires additional study. Objective: This research was designed to evaluate bidirectional causality index (FI) through two-sample Mendelian randomization (MR). Methods: In study, we applied genome-wide association studies (GWAS) perform forward reverse MR within context explore FI epilepsy. The main analysis approach inverse variance...
Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as promising solution capable of accurately identifying infectious pathogens tumors simultaneously. However, critical evidence is still lacking regarding its diagnostic performance distinguishing between pulmonary infections, tumors, non-infectious, non-tumor conditions real settings. In this study, data were gathered...
Abstract Background Radiofrequency catheter ablation (RFCA) is a widely employed method for restoring sinus rhythm(SR) in patients with drug-refractory paroxysmal atrial fibrillation (PAF). Three-dimensional speckle tracking echocardiography (3DSTE) precise and practical imaging technique clinically assessing myocardial function the left atrium. The objective of this study was to assess alterations three-dimensional strains predict recurrence PAF following RFCA. Methods A total 109 diagnosed...
Immunotherapy targeting CD4 + FoxP3 regulatory T cells (Tregs) through lymphocyte depletion is being investigated as cancer treatment. This study examines the efficacy and limitations of across various models. We examined in syngeneic mouse tumor models including B16 melanoma, Renca kidney cancer, Hepa1-6 hepatocellular carcinoma. The explored relationship between MHC II expression growth, immune response, survival. In models, suppressed growth but accelerated tumors. had high while other...
Recently, we delved into the impact of o-aryl halogen effect on nickel α-diimine-catalyzed ethylene polymerization and uncovered some intriguing findings. Building this work, now further explore analogous...