A5100728615- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Fibroblast Growth Factor Research
- High Altitude and Hypoxia
- Climate Change and Health Impacts
- Ion Transport and Channel Regulation
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Hydrogen's biological and therapeutic effects
- Air Quality Monitoring and Forecasting
- COVID-19 Clinical Research Studies
- Renal function and acid-base balance
- Tracheal and airway disorders
- Electrolyte and hormonal disorders
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Glutathione Transferases and Polymorphisms
- Urban Green Space and Health
- Mechanisms of cancer metastasis
Fudan University
2013-2024
Shanghai Municipal Commission of Health and Family Planning
2024
Jinshan Hospital of Fudan University
2024
Huashan Hospital
2024
Shanghai Clinical Research Center
2024
Zhongshan Hospital
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2021
Sun Yat-sen University
2013-2021
Yunnan Normal University
2020
Bristol-Myers Squibb (United States)
2017
The associations of long-term exposure to various constituents fine particulate matter (≤2.5 μm in aerodynamic diameter, PM2.5) air pollution with lung function were not clearly elucidated developing countries. aim was evaluate the main PM2.5 China. This is a nationwide, cross-sectional analysis among 50,991 study participants from China Pulmonary Health study. Multivariable linear regression models used obtain differences forced expiratory volume 1 s (FEV1), vital capacity (FVC), FEV1/FVC,...
Accurate diagnosis of chronic obstructive pulmonary disease (COPD) and exacerbations by metabolic biomarkers enables individualized treatment. Advanced detection platforms rely on designed materials. Here, we design mesoporous PdPt alloys to characterize fingerprints for diagnosing COPD exacerbations. As a result, the optimized enable acquisition within seconds, requiring only 0.5 μL native plasma laser desorption/ionization mass spectrometry owing enhanced electric field, photothermal...
Abstract Background To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Methods This prospective, randomized, double-blind, controlled clinical trial 10 centres enrolled patient AECOPD and a Breathlessness, Cough, Sputum Scale (BCSS) score at least 6 points. Eligible were randomly assigned (in 1:1 ratio) receive either or therapy. Primary endpoint...
The evidence is quite limited regarding the constituents of fine particulate matter (PM2.5) responsible for lung dysfunction. We designed a time-series panel study in 28 patients to examine effects 10 major PM2.5 on function with repeated daily measurements from December 2012 May 2013 Shanghai, China. applied linear mixed-effect model combined distributed lag estimate cumulative morning/evening forced expiratory volume 1-s (FEV1) and peak flow (PEF) over week. decreases morning FEV1, evening...
Rationale: It remains unknown whether long-term ozone exposure can impair lung function. Objectives: To investigate the associations between and adult function in China. Methods: Lung results diagnosis of small airway dysfunction (SAD) were collected from a cross-sectional study, China Pulmonary Health Study (N = 50,991). We used multivariable linear logistic regression models to examine with parameters SAD, respectively, adjusting for demographic characteristics, individual risk factors,...
Alveolar overdistension and mechanical stresses generated by repetitive opening closing of small airways alveoli have been widely recognized as two primary mechanistic factors that may contribute to the development ventilator-induced lung injury. A long-duration exposure alveolar epithelial cells even small, shear could lead changes in cytoskeleton production inflammatory mediators. In this paper, we made an attempt estimate situ magnitudes exerted on walls during reopening using a...
BACKGROUNDDifferentiating malignant from nonmalignant body fluids remains a clinical challenge because of the unsatisfying performance conventional cytology. We aimed to improve sensitivity and ubiquity cancer cell detection by assaying universal cancer-only methylation (UCOM) markers in supernatant cell-free DNA (cfDNA).METHODSAn observational prospective cohort including 1,321 multiple cancers was used develop validate cfDNA UCOM diagnostic assay. All samples were divided into 2 portions...
The mammalian peripheral lung contains at least three aquaporin (AQP) water channels: AQP1 in microvascular endothelia, AQP4 airway epithelia, and AQP5 alveolar epithelia. In this study, we determined the role of airspace-to-capillary transport by comparing permeability wild-type mice transgenic null lacking AQP1, AQP4, or AQP1/AQP4 together. An apparatus was constructed to measure weight continuously during pulmonary artery perfusion isolated mouse lungs. Osmotically induced flux (Jv)...
High altitude pulmonary oedema (HAPE) severely affects non-acclimatized individuals and is characterized by alveolar flooding with protein-rich as a consequence of blood-gas barrier disruption. Limited choice for prophylactic treatment warrants effective therapy against HAPE. Keratinocyte growth factor-2 (KGF-2) has shown efficiency in preventing epithelial cell DNA damages vitro. In the current study, effects KGF-2 intratracheal instillation on mortality, lung liquid balance histology were...
Abstract Many studies have determined that AQP1 plays an important role in edema formation and resolution various tissues via water transport across the cell membrane. The aim of this research was to determine both if how is associated with cardiac ischemic injury, particularly development following myocardial infarction (MI). +/+ −/− mice were used create MI model. Under physiological conditions, develop normally; however, setting MI, they exhibit cardioprotective properties, as shown by...
Background: The benefits of noninvasive positive pressure ventilation (NPPV) in patients with hypercapnic COPD are controversial. It is presumed that methodology and appropriate use NIV ventilator might be crucial for the outcomes. With new built-in software, performance can monitored at home, which guarantee compliance use. This study investigated effects home hypercapnia using software monitoring. Methods: current multicenter prospective, randomized, controlled trial enrolled stable GOLD...
Hypoxia and exertion are considered as the two main factors in development of high-altitude pulmonary oedema (HAPE), however its pathophysiology remains unclear. Therefore, we established a model which 32 Sprague–Dawley rats were randomly assigned to normoxic rest, hypoxic exercise exercise. An altitude 4,700 m was simulated using hypobaric hypoxia, while consisted 48 h walk with 15–20 min breaks every 4 h. Arterial blood gas, bronchoalveolar lavage (BAL), lung wet-to-dry weight (W/D) ratio...
Abstract Preservation or restoration of normal alveolar epithelial barrier function is crucial for pulmonary oedema resolution. Keratinocyte growth factor‐2 ( KGF ‐2), a potent cell mitogen, may have role in preventing ventilator‐induced lung injury VILI ), which occurs frequently mechanically ventilated patients. The aim the study was to test ‐2 rats. Forty healthy adult male S prague‐ D awley rats were randomly allocated into four groups, where Groups HVZP (high‐volume zero positive...
Objective: To compare the ability of four biomarkers to distinguish between those with ventilator-associated pneumonia (VAP) vs. lower respiratory tract bacterial colonization in mechanically ventilated intensive care unit (ICU) pediatric patients. Design: Prospective, pilot cohort study. Setting: Tertiary children's hospital, ICU. Patients: All ICU patients >48 hrs were eligible for enrollment April 2006 May 2007. Thirty-three consecutively screened and enrolled after institutional consent...
Abstract Introduction Pulmonary sequestration is a rare congenital malformation characterized by accessory lung tissue supplied an aberrant systemic artery. It often presents with recurrent infections. But fungus infection exceptional. Objectives To help other clinicians deal patients pulmonary complicating cryptococcal infection. Methods We reported case of and eye cryptococcosis did literature review. Results A 20‐year‐old immunocompetent male patient suffered from pain blurred vision,...
Abstract Background High altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which one kind water channels may play role in preservation epithelial integrity high (HAPE). Methods Therefore, established model Wildtype mice AQP5 −/− were assingned to normoxic rest (NR), hypoxic (HR) exercise (HE) group. Mice produced training walk...
Acute respiratory distress syndrome (ARDS) is a complicated pathological cascade process of excessive pulmonary inflammation and alveolar epithelial cell apoptosis that results in dysfunction failure. Some cases ARDS can result more severe state fibrosis, referred to as postinjury lung fibrosis. The mortality incidence rate are high, particularly when it leads continuing interstitial which requires urgent treatment appropriate management. lipopolysaccharide (LPS)-induced acute injury (ALI)...