A5100744697- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Vestibular and auditory disorders
- RNA regulation and disease
- Metabolism and Genetic Disorders
- Connexins and lens biology
- Ear Surgery and Otitis Media
- Respiratory Support and Mechanisms
- Advanced Glycation End Products research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Speech and Audio Processing
- Bat Biology and Ecology Studies
- Neuroscience and Neural Engineering
- Barrier Structure and Function Studies
- TGF-β signaling in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diet and metabolism studies
- Renal Diseases and Glomerulopathies
- Gastrointestinal motility and disorders
- Neonatal Respiratory Health Research
- Neurological and metabolic disorders
- Antimicrobial Peptides and Activities
- Lung Cancer Research Studies
Zhongshan Hospital
2024
Fudan University
2024
First Affiliated Hospital of Zhengzhou University
2024
Shanghai Jiao Tong University
2008-2022
Shanghai Sixth People's Hospital
2008-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Chongqing Medical University
2020
Ruijin Hospital
2019
Zhejiang University
2004
Xinxiang Medical University
2000
In Brief Objectives: (1) To determine whether high-frequency sensorineural hearing loss (HF SNHL) is accompanied by deterioration in temporal resolution the low-frequency region where sensitivity within normal range. (2) evaluate such processing deficits contribute to speech perception difficulty noise. Design: A between-group design was employed, using subjects either with or without and matched age. Temporal evaluated amplitude modulation (AM) detection gap tasks. restrict evaluation...
Platelet-leucocyte gel (PLG), a new biotechnological blood product, has hitherto been used primarily to treat chronic ulcers and promote soft-tissue bone regeneration in wide range of medical fields. In this study, the antimicrobial efficacy PLG against Staphylococcus aureus (ATCC 25923) was investigated rabbit model osteomyelitis. Autologous injected into tibial canal after inoculation with Staph. aureus. The prophylactic evaluated by microbiological, radiological histological examination....
Abstract Aims To investigate the associations among heteroplasmy levels (i.e. proportions of mutant and wild‐type mitochondrial DNA in same cell), function clinical severity m.3243A>G mutation. Methods A total 17 participants carrying mutation sex‐ age‐matched healthy controls were included this study. Heteroplasmy leukocytes, saliva urine sediment determined by pyrosequencing. The evaluation endocrinological, audiological ophthalmological examinations. Mitochondrial was peripheral blood...
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD) utilizing prospective cohort Mendelian randomization. The dataset contained a substantial of 426,911 participants from UK Biobank, discussing IBS PD with Cox proportional hazards models case-control analysis while adjusting for covariates such as age, gender, ethnicity education level. In univariate regression model, risk was reduced in patients (HR: 0.774, 95%CI: 0.625-0.956,...
Acute respiratory distress syndrome (ARDS) is a complicated pathological cascade process of excessive pulmonary inflammation and alveolar epithelial cell apoptosis that results in dysfunction failure. Some cases ARDS can result more severe state fibrosis, referred to as postinjury lung fibrosis. The mortality incidence rate are high, particularly when it leads continuing interstitial which requires urgent treatment appropriate management. lipopolysaccharide (LPS)-induced acute injury (ALI)...
The syndrome of maternally inherited diabetes and deafness (MIDD) is typically caused by the m.3243A>G mutation widely considered inherited. In our study, we aimed to investigate heredity way among pedigrees with MIDD discover novel mitochondrial DNA mutations related atypical clinical phenotypes. Heteroplasmy levels in peripheral blood, saliva, urine sediment 31 individuals from 10 unrelated were measured pyrosequencing. Clinical evaluations including endocrinological, audiological,...
In this study, we investigated the role of MAP kinase phosphatase-1 (MKP-1) and rosiglitazone (RSG) in glucocorticoid resistance sensitivity, respectively, using a guinea pig model lipopolysaccharide- (LPS-) induced sudden sensorineural hearing loss (SSHL). The pigs were divided into control, LPS, LPS+dexamethasone (DEX), LPS+RSG, LPS+DEX+RSG groups. Their was screened by auditory brainstem response measurement. Immunofluorescence staining used to identify location MKP-1 inner ear....
Isolated pulmonary Langerhans cell histiocytosis (PLCH) is rare in adults. The gold standard diagnosis requires surgical lung biopsy. However, few cases have been diagnosed with transbronchial cryobiopsy (TBCB) sampling the early stages of disease, particularly China.A 50-year-old man was referred for dry cough and exertional dyspnea more than 1 week. High-resolution computed tomography (HRCT) chest revealed symmetric nodules cyst lesions upper lobe infiltrate. Further history taking...
Waardenburg syndrome (WS) is an inherited auditory-pigmentary characterized by deafness and pigment abnormalities. Here, we generated induced pluripotent stem cell (iPSC) line using episomal plasmid vectors from the fibroblasts of 8-year-old boy affected with WS, caused a novel mutation in SOX10 gene (NM_006941.3: c.937_947del; p.Tyr313Argfs*85), concurrent hotspot GJB2 (NM_004004.5:c.235delC; p.Leu79Cysfs*3). The expression pluripotency markers iPSC was verified at both mRNA protein levels...
This study explored whether the time-compressed speech perception varied with degree of hearing loss in high-frequency sensorineural (HF SNHL) individuals. 65 HF SNHL individuals different cutoff frequencies were recruited and further divided into mildly, moderately, and/or severely affected subgroups terms averaged thresholds all exhibiting loss. Time-compressed recognition scores under both quiet noisy conditions gap detection within low that had normal obtained from patients compared data...
Objectives . To analyze the clinical application of SoundBite bone conduction hearing aids by assessing improvement speech recognition and scores benefit scale questionnaire for patients with single-sided deafness (SSD). Design Nine aged 24 to 61 years SSD more than 3 months were enrolled in this study. The could understand repeat Mandarin have good compliance measurements evaluated before after one month wearing using pure tone audiometry threshold, quiet noise, Glasgow Benefit Inventory...
To study the relative contribution of acoustic temporal fine structure (TFS) cues in low-, mid-, and high-frequency regions to Mandarin sentence recognition.Twenty-one subjects with normal hearing were involved a recognition using TFS. The TFS information was extracted from 10 3-equivalent rectangular bandwidth-wide bands within range 80 8858 Hz Hilbert transform assigned regions. Percent-correct scores obtained presented one, two, or three frequency weights calculated least-squares...
Objective To evaluate the potential ototoxicity of high‐dose celecoxib, a selective cyclooxygenase‐2 (COX‐2) inhibitor. Study Design Prospective animal study. Setting Laboratory. Methods Twenty adult male Sprague Dawley rats were divided into 2 groups for hearing and tinnitus tests, respectively. The auditory brain‐stem response (ABR) gap prepulse inhibition acoustic startle (GPIAS) used as indicators loss tinnitus, respectively, measured before at 2, 4, 6, 8, 12, 24, 48 hours after...
Mutations in the COL4A3 gene are frequently reported to be associated with various types of hereditary nephropathy. encodes α 3 chain type IV collagen, which is main structural protein basement membrane. this always related kidney performance, and deafness ocular lesion have also been reported. In study, using next-generation sequencing, we investigated DNA a family visiting clinic for hearing loss. A new missense mutation was found 5 patients, c.3227C>T (p.P1076L). Based on these...
The acceptable noise level (ANL) was defined by subtracting the background (BNL) from most comfortable listening (MCL) (ANL = MCL − BNL). This study compared ANL obtained through different methods in 20 Chinese subjects with normal hearing. tested Mandarin speech materials using a loudspeaker or earphones, each subject himself audiologist. presentation and response modes were as follows: (1) self-adjusted levels audiometer controls (LS method); (2) signaling audiologist to adjust (LA (3)...
Temporal modulation transfer function (TMTF) is one of the most common methods for evaluating temporal acuity in auditory system. In this experiment, we recorded cortical responses to amplitude tone carriers from implanted electrodes guinea pigs generate TMTFs by calculating response changes as a frequencies (Mfs). High-frequency hearing loss above 8 kHz was established using overstimulation (12 kHz, 110 dB SPL 30 hours). The impact acoustic trauma on resolution low-frequency range (below...
Purpose. Slc26a4-/- mice exhibit severer defects in the development of cochlea and develop deafness, while underlying mechanisms responsible for these effects remain unclear. Our study was to investigate potential mechanism linking SLC26A4 deficiency hearing loss. Materials Methods. RNA sequencing applied analyze differential gene expression stria vascularis (SV) from wildtype mice. GO KEGG pathway analysis were performed. Quantitative RT-PCR validate candidate genes affected by Slc26a4....