A5101791500- Viral Infections and Immunology Research
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Parkinson's Disease Mechanisms and Treatments
- Animal Virus Infections Studies
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Pneumonia and Respiratory Infections
- Mitochondrial Function and Pathology
- Genetic Associations and Epidemiology
- Immune Response and Inflammation
- Trace Elements in Health
- Neurological Disease Mechanisms and Treatments
- Bacterial Infections and Vaccines
- Coenzyme Q10 studies and effects
- Inflammasome and immune disorders
- Neonatal and Maternal Infections
- Infectious Encephalopathies and Encephalitis
- ATP Synthase and ATPases Research
- Hepatitis C virus research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- RNA regulation and disease
- Neurological diseases and metabolism
Hunan Children's Hospital
2008-2025
First Affiliated Hospital of Zhengzhou University
2022-2025
Zhengzhou University
2024
Shanghai Institute of Materia Medica
2016-2023
Chinese Academy of Sciences
2016-2023
Shandong University
2022
Yangzhou University
2020
State Key Laboratory of Drug Research
2018
China Pharmaceutical University
2016-2018
Boston Children's Hospital
2013-2014
Natural killer (NK) cells are key players in tumor immunosurveillance, and metabolic adaptation manipulates their fate functional state. The nicotinamide adenine dinucleotide (NAD + ) has emerged as a vital factor to link cellular metabolism signaling transduction. Here, we identified NAD central hub determine the homeostasis function of NK cells.NAD level was elevated activated cells. supplementation not only enhanced cytokine production cytotoxicity but also improved proliferation...
Doxorubicin (DOX), a widely used anti-tumor drug, can give rise to severe cardiotoxicity by oxidative stress and cell apoptosis, which restricts its clinical application. α-Linolenic acid (ALA) has been shown serve as potent cardioprotective agent. The aim of this study was explore the protective effects ALA on DOX-induced underlying molecular mechanisms for cardioprotection in rats. Rats were randomly divided into four groups administrated with normal saline, (500 µg/kg), DOX (2.5 mg/kg),...
We developed the first nickel-catalyzed direct ortho-thiolation of N-benzoyl α-amino acid derivatives. This novel strategy showed wide generality, functional tolerance, and high regioselectivity. In addition, dipeptide derivatives were also compatible with this transformation system, providing a potential protocol for modification peptide
Abstract Introduction Septic cardiomyopathy is a common complication of sepsis with high morbidity and mortality, but lacks specific therapy. This study aimed to reveal the role circTLK1 its potential mechanisms in septic cardiomyopathy. Materials Methods The vitro vivo models were established. Cell viability apoptosis detected by CCK8, TUNEL flow cytometry, respectively. LDH, CK, SOD, MDA, ATP, 8‐OHdG, NAD+/NADH ratio, ROS level, mitochondrial membrane cytochrome C distribution evaluated...
Background: Lacunar stroke accounts for a quarter of all strokes, but little is known about the underlying pathological mechanisms. Analysis serum metabolites may allow better understanding biological processes. Mendelian randomization (MR) can provide information on causality associations. Aims: To identify causal relationships between and lacunar stroke. Methods: We applied two-sample MR analysis to evaluate 486 The inverse-variance weighted (IVW) method was used estimate relationship...
Aging | doi:10.18632/aging.205444. Jing-Jing Shi, Cheng-Yuan Mao, Ya-Zhou Guo, Yu Fan, Xiao-Yan Hao, Shuang-Jie Li, Jie Tian, Zheng-Wei Hu, Meng-Jie Jia-Di Dong-Rui Ma, Meng-Nan Chun-Yan Zuo, Yuan-Yuan Liang, Yu-Ming Xu, Jian Yang, Chang-He Shi
Background The glymphatic system plays a crucial role in clearing metabolic waste from the brain, facilitating exchange between cerebrospinal fluid and interstitial fluid, supporting brain homeostasis. However, quantifying function has been challenging. Diffusion Tensor Imaging Along Perivascular Space (DTI-ALPS) method offers non-invasive approach to assess by calculating an index that reflects mobility within brain. This study aimed identify genetic variants associated with ALPS explore...
An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)2 catalyst, alcohols the alkoxylation reagents, and PhI(OAc)2 oxidant, showed wide generality, good functional tolerance, high monoselectivity regioselectivity.
The innate DNA sensing receptors are one family of pattern recognition and play important roles in antiviral infections, especially viral infections. Among the multiple sensors, cGAS has been studied intensively is most defined mammals. However, sensors chickens have not much studied, chicken still fully understood. In this study, we investigated cGAS-STING signal axis, revealed its synergistic activity, species-specificity, essential sites cGAS. Importantly, both STING exhibited effects...
Pediatric bacterial meningitis (PBM) remains a devastating disease that causes substantial neurological morbidity and mortality worldwide. However, there are few large-scale studies on the pathogens causing PBM their antimicrobial resistance (AMR) patterns in China. The present multicenter survey summarized features of etiological agents characterized AMR patterns. Patients diagnosed with were enrolled retrospectively at 13 children's hospitals China from 2016 to 2018 screened based review...
Background: A high level of education or intelligence (IQ) is reported to be a risk factor for Parkinson’s disease (PD). The purpose this study was systematically examine the causal relationships between IQ, educational attainment (EA), cognitive performance, and PD. Methods: We used summary statistics from genome-wide association studies on EA, Four (GWAS) data PD were comprehensively explore relationship, including GWAS (regardless sex), age at onset GWAS, male with female data. conducted...
Small-molecule fibroblast growth factor receptor (FGFR) inhibitors have emerged as a promising antitumor therapy. Herein, by further optimizing the lead compound 1 under guidance of molecular docking, we obtained series novel covalent FGFR inhibitors. After careful structure–activity relationship analysis, several compounds were identified to exhibit strong inhibitory activity and relatively better physicochemical pharmacokinetic properties compared with those 1. Among them, 2e potently...
Abstract Background The coexistence of hepatitis B surface antigen (HBsAg) and antibody (HBsAb) represents an uncommon serological pattern observed in patients with virus (HBV) infection, its underlying mechanism clinical significance have not been well established. aim this study was to investigate the association between profile treatment outcomes children chronic (CHB). Methods This retrospective cohort included 372 treatment-naïve CHB from Hunan Children’s Hospital. participants were...
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD) utilizing prospective cohort Mendelian randomization. The dataset contained a substantial of 426,911 participants from UK Biobank, discussing IBS PD with Cox proportional hazards models case-control analysis while adjusting for covariates such as age, gender, ethnicity education level. In univariate regression model, risk was reduced in patients (HR: 0.774, 95%CI: 0.625-0.956,...
Background. This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional medicine (TCM) granule, in patients with severe hand, foot, mouth disease (HFMD) by conducting prospective, controlled, randomized trial. Methods. 355 HFMD were randomly assigned receive conventional therapy alone, injection plus therapy, or TCM enema for 7-10 days. Results. There no significant difference incidence major complications between groups. Median time fever...
A direct cobalt-catalyzed oxidative coupling between C(sp2)-H in unactivated benzamides and C(sp3)-H simple alkanes, ethers toluene derivatives was explored. This protocol achieves C-C formation without using alkyl or aryl halide surrogates exhibits high practicality with ample substrate scope. The method provides a new way to construct linear five- six-membered ring moieties bioactive molecules.
The innate immunity DNA sensors have drawn much attention due to their significant importance against the infections with viruses and intracellular bacteria. Among multiple sensors, IFI16 cGAS are two major ones, subjected extensive studies. However, these in livestock animals not been well defined. Here, we studied porcine cGAS, mutual relationship. We found that both enable STING dependent signaling downstream IFN upon transfection HSV-1 infection; plays a role signaling. In terms of...
Abstract Background Patients with Parkinson's disease (PD) have consistently demonstrated brain structure abnormalities, indicating the presence of shared etiological and pathological processes between PD structures; however, genetic relationship remains poorly understood. Objective The aim this study was to investigate extent architecture structural phenotypes (BSPs) identify genomic loci. Methods We used summary statistics from genome‐wide association studies conduct MiXeR...
Among the various manifestations of COVID-19, neurological implications SARS-CoV-2 infection are significant concern. Marchiafava–Bignami disease (MBD), a neurodegenerative disorder, exhibits clinical spectrum ranging from mild progressive dementia in its chronic form to states acute coma and varied mortality rates. Acute MBD primarily occurs alcoholics malnourished individuals is characterized by sudden loss consciousness, seizures, confusion, psychosis. We herein report case presenting as...
<title>Abstract</title> Background Pathogenic <italic>HSD17B10</italic> gene variants cause HSD10 mitochondrial disease (HSD10 MD), which results in a wide spectrum of symptoms ranging from mild to severe. Typical include intellectual disability, choreoathetosis, cardiomyopathy, neurodegeneration, and abnormal behavior. This study aimed investigate novel c.59C > T variant the clinical phenotypic features MD (neonatal form) patients. Results We describe 2-month 12-day-old Chinese boy with...