A5040064586- Respiratory viral infections research
- COVID-19 Impact on Reproduction
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- COVID-19 and healthcare impacts
- Infant Nutrition and Health
- Gestational Diabetes Research and Management
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Viral-associated cancers and disorders
- Viral gastroenteritis research and epidemiology
- Pregnancy and Medication Impact
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- COVID-19 diagnosis using AI
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2016-2025
Hubei Provincial Center for Disease Control and Prevention
2024
Second Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Fukushima Medical University
2009
Wuhan Institute of Virology
2005-2006
Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, disease 2019 (COVID-19), affecting more than seventeen million people around world. Diagnosis and treatment guidelines for clinicians caring patients are needed. In early stage, we have issued “A rapid advice guideline diagnosis (2019-nCoV) infected pneumonia (standard version)”; now there many direct evidences emerged may change some previous recommendations it ripe...
Prenatal dexamethasone exposure (PDE) can lead to increased susceptibility various diseases in adult offspring, but its effect on gut microbiota composition and the relationship with disease remains unclear. In this study, we find sex-differential changes of 6-month-old infants prenatal therapy (PDT) that persisted female up 2.5 years age altered bile acid metabolism. PDE offspring rats show abnormal colonization cholestatic liver injury. The aberrant be attributed inhibited Muc2 expression...
Abstract Background To explore the epidemiologic and clinical features of, interactions among, multipathogen infections in hospitalized children with acute respiratory tract infection (ARTI). A prospective study of admitted ARTI was conducted. Peripheral blood samples were analyzed by indirect immunofluorescence to detect agents including syncytial virus; adenovirus; influenza virus (Flu) types B; parainfluenza (PIV) 1, 2, 3; chlamydia pneumonia; mycoplasma pneumonia. medical history each...
Immunologic dysfunction due to coronavirus disease 2019 (COVID-19) is closely related clinical prognosis, and the inflammatory response of pregnant women may affect directional differentiation function fetal immune cells.We sought analyze status newborns from mothers with COVID-19 in third trimester.Along collecting data 51 their respective mothers, we recorded immunophenotypes cytokine immunoglobulin levels newborns.None showed fever or respiratory distress during hospitalization. Detection...
Numerous studies have shown that Epstein-Barr virus (EBV) and cytomegalovirus (CMV) can infect immunocompetent patients simultaneously with other agents. Nonetheless, multiple infections agents in EBV/CMV-infected children received little attention. We conducted a retrospective study of suspected infectious mononucleosis. Peripheral blood samples were analyzed by indirect immunofluorescence to detect EBV, CMV respiratory including syncytial virus; adenovirus; influenza types A B;...
Abstract At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics infantile serum antibodies mother SARS-CoV-2 has not been well described. In this study, we analyzed seroconversion 27 newborns 26 pregnant women SARS-CoV-2. IgG positive rate parturient was 80.8%, and half their obtained maternal IgG. transfer rates were 18.8% 81.8% in those...
Premature delivery interrupts the natural growth of fetus. The postnatal healthy management preterm infants still follows term standards after a postmenstrual age (PMA) 40 weeks and there is lack research on longitudinal dynamic tracks infants. Based database established by Wuhan University Internet+ Early Childhood Development Alliance in China, information infants, including birth registration health follow-ups from 2016 to 2022, was incorporated into system. Standardized anthropometric...
Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2, and pNS1/2) tested whether NS1 or NS2 would trigger SOCS1 SOCS3 expression. These NS proteins inhibited interferon- (IFN-) α through mechanism involving induction SOCS3, appeared be different from autocrine...
Information on SARS-CoV-2 asymptomatic infection and infectivity in children is limited. In this study, we aimed to report the epidemiological clinical characteristics of a familial cluster including with SARS-CoV-2. On February 1, 2020, two children(case 1 case 2), an 8-year-old girl 9-year-old boy, were admitted isolation ward Xiangyang Central Hospital, Hubei province, China, diagnosis COVID-19. Before admission, they had been staying at home their father never contacted any confirmed...