A5100427484- Bacterial biofilms and quorum sensing
- Craniofacial Disorders and Treatments
- Antibiotic Resistance in Bacteria
- Cleft Lip and Palate Research
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Vibrio bacteria research studies
- Lipoproteins and Cardiovascular Health
- Single-cell and spatial transcriptomics
- Oral microbiology and periodontitis research
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cell Image Analysis Techniques
- Streptococcal Infections and Treatments
- Bacterial Genetics and Biotechnology
- Pharmacological Effects of Natural Compounds
- Advanced Fiber Laser Technologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial infections and disease research
- melanin and skin pigmentation
Henan University of Science and Technology
2016-2025
Xinxiang Medical University
2023-2025
Nanjing University
2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Wayne State University
2020-2024
Heilongjiang University of Chinese Medicine
2024
Wuhan University of Technology
2023
Peking University
2022
Ministry of Agriculture and Agro Based Industry
2022
Organismal phenotypes frequently involve multiple organ systems. Histology is a powerful way to detect cellular and tissue phenotypes, but largely descriptive subjective. To determine how synchrotron-based X-ray micro-tomography (micro-CT) can yield 3-dimensional whole-organism images suitable for quantitative histological phenotyping, we scanned whole zebrafish, small vertebrate model with diverse tissues, at ~1 micron voxel resolutions. Micro-CT optimized characterization (histotomography)...
Parkinson's disease (PD) is a tricky neurodegenerative characterized with motor deficits and gastrointestinal (GI) dysfunction. Gut microbiota disturbance reported to be involved in the clinical phenotypes of PD its pathogenesis through brain-gut-microbiota axis. Resveratrol natural polyphenol that possesses various biological activities alleviating many diseases, including PD. The present study was aimed investigate role gut resveratrol-treated mice. A chronic mouse model generated via...
Purpose: The purpose of this study was to explore the difference and association between intestinal microbiota plasma metabolomics type 2 diabetes mellitus (T2DM) normal group identify potential biomarkers that contribute most in metabolites.Methods: Six male ZDF model (fa/fa) rats were fed by a Purina #5008 Lab Diet (crude protein 23.5%, crude fat 6.5%) for 3 weeks their age-matched 6 control (fa/+) rodent diet.Their stool blood samples collected at 12 weeks.To analyze microbial populations...
Streptococcus suis, a zoonotic pathogen, is commonly found as commensal bacterium in the respiratory tracts of pigs. Under specific conditions, it becomes invasive and enters blood, causing severe systemic infections. For S. effective acquisition carbon sources different host niches necessary for its survival. However, now, our understanding metabolism suis within highly restricted. Pyruvate formate lyase (PFL) plays crucial role bacterial survival glucose-limited hypoxic tissues. Here, we...
The isolation and identification, genetic typing, antibiotic sensitivity, biofilm formation of avian Escherichia coli in central China was studied. A total 256 isolates E. were obtained, classified into groups: (50.78%, 130/256), B1 (11.72%, 30/256), B2 (17.58%, 45/256), D (19.92%, 51/256). Drug susceptibility testing revealed that the strains showed a high drug resistance rate against penicillin, aztreonam, rifampicin, kanamycin, clindamycin, gentamicin, with 92.19% exhibiting multi-drug...
BACKGROUND：: Existing studies have revealed functional abnormalities in certain brain regions of patients with schizophrenia (SZ), but the relationships between these and their impact on disease progression remain unclear. Fifty-six SZ 56 healthy controls were included. Based resting-state magnetic resonance imaging, we analyzed fractional amplitude low-frequency fluctuations (fALFF), regional homogeneity (ReHo), degree centrality (DC). Statistically significant metrics selected as features,...
With the increasing severity of antibiotic resistance and other adverse consequences, animal experiments clinical trials investigating use phages for control prevention enteric bacterial infections are growing. However, effects antibiotics on organisms when treating intestinal have not been precisely studied.
Abstract Background Cryptosporidium is an important zoonotic pathogen responsible for severe enteric diseases in humans and animals. However, the molecular mechanisms underlying host interactions are still not clear. Methods To study roles of circRNAs cells during infection, expression profiles HCT-8 infected with C. parvum were investigated using a microarray assay, regulatory role significantly upregulated circRNA, ciRS-7, was infection. Results infection caused notable alterations cells,...
The assembly and activity of cytochrome c oxidase is dependent on the availability heme A, one its essential cofactors. In eukaryotes, two inner mitochondrial membrane proteins, O synthase (Cox10) A (Cox15), are required for biosynthesis. this report, we demonstrate that in Saccharomyces cerevisiae transcription COX15 regulated by Hap1, a factor whose positively controlled intracellular concentration. Conversely, COX10, physiological partner COX15, does not share same regulatory mechanism...
A new triterpenoid saponin named clematichinenoside AR2, along with the six known compounds, was isolated and characterized from Clematis chinensis Osbeck (Ranunculaceae), a commonly used traditional Chinese medicine anti-inflammatory anti-rheumatoid activities. The structure of elucidated as 3-O-β-[(O-α-l-rhamnopyranosyl-(1 → 6)-O-β-d-glucopyranosyl-(1 4)-O-β-d-glucopyranosyl-(1 4)-O-β-d-ribopyranosyl-(1 3)-O-α-l-rhamnopyranosyl-(1 2)-α-l-arabinopyranosyl)oxy]olean-12-en-21α-hydroxy-28-oic...
Purpose: We aimed to examine the association between plasma trimethylamine N-oxide (TMAO), a gut microbial metabolite from dietary phosphatidylcholine, and coronary atherosclerotic burden in patients with type 2 diabetes (T2D). Methods: In total, 349 T2D were studied, including 70 controls 279 artery disease (CAD) by angiography. Coronary is quantified number of diseased branches SYNTAX (Synergy PCI Taxus Cardiac Surgery) score. Plasma TMAO levels determined UHPLC–MS/MS technique. Results:...
Soliton self-frequency shift (SSFS) is an efficient technique of generating broadband tunable femtosecond optical pulses. By using large-mode-area (LMA) waveguides such as photonic-crystal (PC) rods or LMA fibers, SSFS capable solitons with tens even >100 nJ pulse energy, enabling deep-tissue multiphoton microscopy (MPM) the unprecedented imaging depth. MPM signals are proportional to repetition rate laser. Here, we demonstrate enhancing in waveguides, through polarization...
Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening plasma biomarkers has great significance optimizing and predicting the complications T2DM.We used a special diet, Purina #5008, to induce in Zucker leptin receptor gene-deficient rats (fa/fa) establish diabetic fatty (ZDF) rats, simulating early stage T2DM. The differentially expressed proteins (DEP) lipids (DEL), as potential biomarkers, were screened compare expression levels ZDF their basic diet-fed wild-type...