A5001043059- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Hypoxia, and Metabolism
- Cocoa and Sweet Potato Agronomy
- Material Properties and Processing
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Risk Factors
- Zoonotic diseases and public health
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- Adrenal Hormones and Disorders
- RNA Interference and Gene Delivery
- Plant Parasitism and Resistance
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2024
Peking University
2011-2022
Peking University First Hospital
2011-2022
Hebei Medical University
2007-2021
Fourth Hospital of Hebei Medical University
2007-2021
Affiliated Zhongshan Hospital of Dalian University
2015-2020
National Health and Family Planning Commission
2020
CD36 is a class B scavenger receptor recognizing variety of ligands including long-chain fatty acids and modified LDL. We investigated whether genetic variability at this locus determinant free acid (FFA) plasma levels risk coronary artery disease (CAD) in Caucasians. Typing 21 polymorphic markers, evenly spanning the gene, revealed two linkage disequilibrium (LD) blocks that could be tagged by five polymorphisms (-33137A>G, -31118G>A, 25444G>A, 27645del>ins 30294G>C). In 585 non-diabetic...
Fungal pathogens secrete effector proteins to suppress plant basal defense for successful colonization. Resistant plants, however, can recognize effectors by cognate R induce effector-triggered immunity (ETI). By analyzing secretomes of the vascular fungal pathogen Verticillium dahliae, we identified a novel secreted protein VdSCP7 that targets nucleus. The green fluorescent (GFP)-tagged gene with either mutated nuclear localization signal motif or additional export was transiently expressed...
Glycemic control is critical for managing transcatheter aortic valve replacement (TAVR) patients, especially those in intensive care units (ICUs). Emerging metrics such as the hemoglobin glycation index (HGI), stress hyperglycemia ratio (SHR), and glycemic variability (GV) offer advanced insights into glucose metabolism. However, their prognostic implications short- long-term outcomes post-TAVR remain underexplored. This retrospective cohort study analyzed 3342 ICU-admitted TAVR patients via...
Two single nucleotide polymorphisms (SNPs) at the adiponectin locus (+45T>G and +276G>T) have been associated with low circulating levels, insulin resistance, type 2 diabetes. We investigated whether these genetic markers are determinants of coronary artery disease (CAD) in diabetic patients.A total 376 consecutive patients were studied: 142 case subjects stenosis >50% or previous myocardial infarction 234 control no symptoms, electrocardiogram (ECG) signs ischemia, a normal ECG stress test...
Abstract Ocular inflammations are common diseases that may lead to serious vision‐threatening obstacles. Eye drops for antiinflammation therapy need be administered multiple times daily at a high dosage due the rapid precorneal removal and low bioavailability of drugs. To overcome these problems, cRGD‐functionalized DSPE‐PEG 2000 nanomicelle (DSPE‐PEG ‐cRGD) encapsulated with flurbiprofen is proposed. The tailored nanomicelles trigger specific binding integrin receptors on ocular surface,...
DNA methylation plays multiple regulatory roles in crop development. However, the relationships of polymorphisms with genetic polymorphisms, gene expression, and phenotypic variation natural populations remain largely unknown. Here, we surveyed high-quality methylomes, transcriptomes, genomes obtained from 20-days-post-anthesis (DPA) cotton fibers 207 accessions extended classical framework population genetics to epigenetics. Over 287 million single (SMPs) were identified, 100 times more...
Curcuma longa is a plant that belongs to the ginger family, Zingiberaceae. It has been used in Siddha medicine for thousands of years Asia. Parkinson's disease (PD) degenerative disorder central nervous system affects motor brain. Death dopamine-producing cells substantia nigra leads PD. Exposure salsolinol, which an endogenous neurotoxin, associated with damage cells. The present study assessed toxicity salsolinol SH-SY5Y human neuroblastoma and subsequently investigated neuroprotective...
Hepcidin deficiency is known to cause body iron accumulation and bone microarchitecture defects, but the exact underlying mechanisms of hepcidin deficiency-induced loss remain unclear. Our objective was understand molecular mechanism loss.The phenotypes wild type (WT) knockout (Hepcidin-KO) mice were measured by microcomputed tomography. The osteoclastic marker tartrate-resistant acid phosphatase staining. osteoblastic immunostaining osteocalcin. Primary differentiation performed using...
Background Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase (PC1/3) from proinsulin proglucagon, are associated with type 2 diabetes (T2DM) coronary artery disease (CAD). The aim of this study is to investigate the association PCSK1 gene, which encodes PC1/3, risk CAD in Chinese patients T2DM. Methods We selected genotyped 5 haplotype-tagging single nucleotide polymorphisms (SNPs) at gene (across 39873bp locus) a case-control Han population involving 425...
Background . Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct interactions or by improvements to metabolic function. Both these are thought be at least partly mediated GLP-1 receptor (GLP-1R). This case-controlled study investigated whether polymorphisms in GLP-1R gene affect risk of disease type 2 diabetic patients Chinese Han population. Methods Eleven haplotype-tagging single nucleotide (SNPs), distributed across 22 kb 39 gene, were...
Purpose: We aimed to examine the association between plasma trimethylamine N-oxide (TMAO), a gut microbial metabolite from dietary phosphatidylcholine, and coronary atherosclerotic burden in patients with type 2 diabetes (T2D). Methods: In total, 349 T2D were studied, including 70 controls 279 artery disease (CAD) by angiography. Coronary is quantified number of diseased branches SYNTAX (Synergy PCI Taxus Cardiac Surgery) score. Plasma TMAO levels determined UHPLC–MS/MS technique. Results:...
Endoplasmic reticulum (ER) stress is one of the contributing factors to development β-cell failure in type 2 diabetes. ER response through ATF6 has been shown play an important role insulin resistance and pancreatic function. We investigated whether genetic polymorphisms were associated with risk pre-diabetes a Chinese Han population, they had synergistic effect obesity. Our samples included 828 individuals who diagnosed as pre-diabetic, 620 controls. The minor allele A at rs2340721 was...
Endometriosis, one of the most frequent diseases in gynecology, is a benign but invasive and metastatic disease. The altered expression E-cadherin may play an important role developing endometriosis. In this paper, we discuss association three single nucleotide polymorphisms (SNPs) on gene risk We examined genotype frequency 152 endometriosis patients 189 control women. There was significant difference 3'-UTR C --> T genotypes between controls (P = 0.01). allele (71.1%) significantly higher...
Abstract Background Increasing evidence suggests that adenosine monophosphate‐activated protein kinase (AMPK) plays a critical physiological role in the cardiovascular system. The objective of this study was to assess possible correlation between genetic variability AMPKα1 ( PRKAA1 ) gene and risk disease, as well interactive effects variations environmental factors, on Chinese patients with type 2 diabetes. Methods Five haplotype‐tagging single nucleotide polymorphisms (SNPs) at locus 404...
Aims . We investigated the association between ubiquitin-conjugating enzyme E2Z (UBE2Z) gene SNP rs46522 and risk of CAD in a Chinese Han population with type 2 diabetes explored possible interactive effect environmental factors CAD. Methods 665 patients T2D were enrolled; 390 275 non-CAD patients. Genotype analysis (T>C) was performed using PCR-RFLP. Results The rs47522 associated supposing recessive inheritance model (TT versus CC+CT, <mml:math...
To explore the associations between polymorphisms in SIRT1 and coronary heart disease (CHD) risk Chinese Han patients with type 2 diabetes (T2D). This case-controlled study enrolled 492 T2D: 297 CHD 195 without CHD. Five haplotype-tagging single-nucleotide (rs3818291, rs12242965, rs3818292, rs4746720, rs16924934) were selected from data GRCh37.p13 phase 3 database genotyped by polymerase chain reaction-restriction fraction length polymorphism or sequencing. The rs16924934 G allele was...
Background . Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of AMP-activated protein (AMPK), plays crucial role in cardiovascular system. This study aimed to investigate whether genetic variations STK11 gene affect risk coronary artery disease (CAD) Chinese type 2 diabetics. Methods 5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases 159 CAD-negative controls with diabetes genotyped by polymerase...
Background . Glucose-dependent insulinotropic polypeptide (GIP) is closely related to diabetes and obesity, both of which are confirmed increase the risk coronary artery disease (CAD). Our study aimed investigate whether polymorphisms in GIP genes could affect cardiovascular type 2 diabetic patients Chinese Han population. Methods We selected genotyped two haplotype-tagging single nucleotide (tag-SNPs) (rs2291725 C>T, rs8078510 G>A) gene based on CHB data HapMap Phase II database...
To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated Probucol plus Cilostazol combination individually.In this open-label study, aged 40-75 years were randomized to receive conventional therapy alone, or 100 mg bid, 250 both combination. Endpoints included changes biomarker safety at 12 weeks.Of 200 patients, 165 for per-protocol 160 (QTc intervals) set, respectively. significantly reduced total...
Objective To detect the expressions of circulating microRNAs (miRNAs) peripheral whole blood in Alzheimer’s disease (AD) and investigate potential roles miRNAs as diagnostic biomarkers for Alzheimer's disease. Methods Peripheral samples were obtained from 110 AD patients 150 age- gender-matched normal controls. The concentrations seven candidate miRNAs, including miR-9, miR-29a, miR-29b, miR-101, miR-181c, miR-137and miR-126, measured with a real-time quantitative reverse...