A5100374696- Polyomavirus and related diseases
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Antenna Design and Analysis
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Full-Duplex Wireless Communications
- Neonatal and Maternal Infections
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Streptococcal Infections and Treatments
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Intestinal and Peritoneal Adhesions
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Viral Infections and Immunology Research
- Forest Ecology and Conservation
- Vitamin K Research Studies
Dalian Polytechnic University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2023
Wenzhou Medical University
2009-2023
First Affiliated Hospital of Fujian Medical University
2022
Fujian Medical University
2022
Biology of Infection
2019
Lanzhou University
2011
Beth Israel Deaconess Medical Center
2007-2010
Harvard University
2007-2008
Temple University
2007
Reactivation of the polyomavirus BK (BKV) causes nephropathy (PVN) in kidney transplant (KTx) recipients and may lead to loss renal allograft. We have identified two HLA-A*0201-restricted nine-amino-acid cytotoxic T lymphocyte (CTL) epitopes BKV major capsid protein VP1, VP1(p44), VP1(p108). Using tetramer staining assays, we showed that these were recognized by CTLs 8 10 (VP1(p44)) 5 (VP1(p108)) HLA-A*0201+ healthy individuals, while both elicited a CTL response KTx with biopsy-proven PVN,...
Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic profiles for S identified from pediatric patients in mainland China remains be established.The clinical features, antimicrobial resistance, and multidrug patterns of were retrospectively analyzed at 10 children's hospitals 2016.Among the collected 6132 isolates, pneumococcal diseases mainly occurred children younger than 5 years old (85.1%). The rate clindamycin, erythromycin,...
Introduction Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health worldwide. In December 2015, the Infectious Disease Surveillance of Pediatrics (ISPED) program was organized monitor bacterial epidemiology and resistance trends in children. Methods This retrospective study conducted from January 2016–December 2021 on patients at eleven ISPED-group hospitals. Results From 2016–2021, total 13024 MRSA isolates were obtained The most common age group for...
ABSTRACT JC virus (JCV)-specific CD8 + cytotoxic T lymphocytes (CTL) are associated with a favorable outcome in patients progressive multifocal leukoencephalopathy (PML) and cross-recognize the polyomavirus BK (BKV). We sought to determine frequency phenotype fresh blood of cells specific for two A*0201-restricted JCV epitopes, VP1 p36 p100 , assess their impact on viremia viruria 15 healthy subjects, eight human immunodeficiency virus-positive (HIV ) individuals, nine HIV PML patients)...
Pediatric bacterial meningitis (PBM) remains a devastating disease that causes substantial neurological morbidity and mortality worldwide. However, there are few large-scale studies on the pathogens causing PBM their antimicrobial resistance (AMR) patterns in China. The present multicenter survey summarized features of etiological agents characterized AMR patterns. Patients diagnosed with were enrolled retrospectively at 13 children's hospitals China from 2016 to 2018 screened based review...
Individuals with early-onset depression may be a clinically distinct group particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in Han Chinese population.We examined the clinical features of 1970 women DSM-IV major depressive disorder (MDD) between 30 60 years age across China. Analysis linear, logistic multiple regression models was used to determine association at onset (AAO) continuous, binary discrete...
BK virus—associated hemorrhagic cystitis is a common clinical problem in bone marrow transplant recipients but considered rare other immunosuppressed patient populations. We describe human immunodeficiency virus—infected with non-Hodgkin's lymphoma whom developed; viruria was quantitated urine by immunocytochemistry, and the showed no response to cidofovir.
To investigate the risk factors that contribute to smoking in female patients with major depressive disorder (MDD) and clinical features depressed smokers.We examined status 6120 Han Chinese women MDD (DSM-IV) between 30 60 years of age across China. Logistic regression was used determine association for status.Among recurrent there were 216(3.6%) current smokers, 117 (2.0%) former smokers 333(5.6%) lifetime smokers. Lifetime had a slightly more severe illness, characterized by episodes,...
Abstract This study aimed to investigate the mechanism of mangiferin on regulating endoplasmic reticulum (ER) stress in acute liver injury. The mouse model injury was established by injection LPS/D-GalN. primary hepatocytes were stimulated with LPS induce vitro model. effect miR-20a/101a luciferase activity Nrf2 3′-UTR assessed reporter assay. Mangiferin improved function, inhibited oxidative and ER down-regulated expressions miR-20a miR-101a LPS/D-GalN-induced mice LPS-induced hepatocytes....
Human cytomegalovirus is a significant agent of hepatic involvement in neonates. In this study, we investigated the polymorphisms and features viral genes UL144 UL146 as well their significance to congenital involvement. 79 neonates with infection involvement, full length were successfully amplified 73.42% 60.76% cases, respectively. Sequencing indicated that both hypervariable. Notably, genotype B was highly associated aspartate aminotransferase (P = 0.028) lactate dehydrogenase 0.046)....
Background Dysthymia is a form of chronic mild depression that has complex relationship with major depressive disorder (MDD). Here we investigate the role environmental risk factors, including stressful life events and parenting style, in patients both MDD dysthymia. We ask whether these factors act same way without Results examined clinical features 5,950 Han Chinese women between 30–60 years age across China. confirmed earlier results by replicating prior analyses 3,950 new cases. There...
Human cytomegalovirus (HCMV) infection is globally distributed, and the liver one of major targeting organs. So far, mechanisms for cell organ damage have not fully been elucidated treatments are mainly at symptoms. IL-37 has shown a protective role in certain inflammatory diseases. In present study, potential effect exogenous on murine cytomegalovirus- (MCMV-) infected hepatitis was evaluated through analyses serum transaminases, histopathology cytokine expression, functional state...
Background: Hand, foot and mouth disease (HFMD) is caused mostly by enteroviruses. However, other viral agents also can cause similar syndromes, hence, the infections they are often misdiagnosed clinically. To determine non-enterovirus etiologic in HFMD-like cases, we screened enterovirus-negative samples collected from patients who were clinically diagnosed as HFMD China. Methods: Two hundred previously Wenzhou city of Zhejiang province, Both high throughput sequencing RT-PCR used to screen...
Objective To investigate the application value for predicting human cytomegalovirus(HCMV) infection with viral load in urinary epithehal cell (EC).Methods Peripheral blood and urine specimens from 82 infants HCMV latent 84 active were collected respectively.Plasma DNA levels of lgM/IgG antibody detected by real-time fluorescence quantitative polymernse chain reaction (FQ-PCR) chemiluminescence immunsassay.HCMV pp65 antigen peripheral polymorphonuclear leukocytes (PMNLs) was indirect...
Objective To investigate the relationship between EBV-induced liver injury and caspase-3/6 in children. Methods Data of 249 patients seen from July 2016 to June 2017 who got infection with EBV were collected second affiliated hospital Wenzhou Medical University divided into two groups; 168 diagnosed hepatitis selected for abnormal function group, laboratory tests performed acute phase convalescent phase. Meanwhile 81 patients, whose normal group. Two ml blood plasma was each patient...