A5017054134- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- Congenital Diaphragmatic Hernia Studies
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal and Maternal Infections
- Kruppel-like factors research
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Prenatal Screening and Diagnostics
- Fibroblast Growth Factor Research
- Streptococcal Infections and Treatments
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Paraoxonase enzyme and polymorphisms
- Chemokine receptors and signaling
- Genetic Neurodegenerative Diseases
- Congenital Anomalies and Fetal Surgery
- RNA modifications and cancer
Wenzhou Medical University
2009-2025
First Affiliated Hospital of Wenzhou Medical University
2017-2025
Kidney biopsy is considered the golden criterion for diagnosing etiology of kidney disease but accompanied by non-negligible complications. We explored possibility using urinary microRNA (miRNA) as a non-invasive biomarker hypertensive injury. assessed differential miRNA expressions in kidneys and urine mice with injury induced deoxycorticosterone acetate (DOCA)-salt compared to controls. DOCA-salt treatment significantly increased renal tubular lesions from day 2 mRNA expression...
Diabetes-induced oxidative stress is one of the major contributors to dysfunction endothelial progenitor cells (EPCs) and impaired regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis a hind limb ischemia (HLI) model MT transgenic (JTMT) mice with high-fat diet– streptozocin-induced diabetes. Compared littermate wild-type (WT) diabetic mice, JTMT had improved blood flow recovery after HLI. Similarly, transplantation bone...
Background and Objective: Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants; predicting the degree of BPD at an early life stage difficult. Inflammation crucial risk factor for pathogenesis, neutrophil-to-lymphocyte ratio (NLR) potential systemic inflammatory biomarker. We aimed to assess predictive value NLR BPD. Methods: carried out retrospective, single-center, observational study neonates with gestational ages (GAs) <32 weeks assessed association between...
Abstract Circular RNAs are a class of widespread and diverse endogenous that may regulate gene expression in various diseases, but their regulation function hypertensive renal injury remain unclear. In this study, we generated ribosomal‐depleted RNA sequencing data from normal mouse kidneys injured induced by deoxycorticosterone acetate‐salt hypertension identified at least 4900 circRNA candidates. A total 124 these circRNAs were differentially expressed between the kidneys. Furthermore,...
Acute pancreatitis (AP) is a highly fatal acute inflammation and often accompanied by multiple organ dysfunction syndrome (MODS). The liver, one of the most vulnerable extrapancreatic organs in AP, major involved evolution disease correlates strongly with occurrence MODS. However, etiology pancreatitis-associated liver injury (PALI) has not been clarified currently lacks an effective treatment. 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) cell permeable nucleoside pleiotropic...
Backgrounds: Bronchopulmonary dysplasia (BPD) is a major contributor to mortality in extremely preterm infants. Therefore, it essential identify effective clinical prognostic indicators of BPD and implement early interventions. The objective this study was evaluate the predictive value erythrocyte-related indices, such as hemoglobin (Hb) hematocrit (Hct), for BPD. Methods: This retrospective cohort included 413 neonates with gestational age (GA) < 32 weeks who were admitted First...
Peroxisomes play a central role in lipid metabolism. We previously demonstrated that Pex11a deficiency impairs peroxisome abundance and fatty acid β-oxidation results hepatic triglyceride accumulation. The of dyslipidaemia obesity is investigated here with knockout mice (Pex11a-/- ). Metabolic phenotypes including tissue weight, glucose tolerance, insulin sensitivity, cholesterol levels, profile, oxygen consumption, physical activity were assessed wild-type (WT) Pex11a-/- fed high-fat diet....
Routine blood parameters, such as the lymphocyte (LYM) count, platelet (PLT) lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte (NLR), lymphocytes multiplied by platelets (LYM*PLT) and mean volume-to-platelet (MPV/PLT), are widely used to predict prognosis of infectious diseases. We aimed explore value these parameters in early identification influenza virus infection children.We conducted a single-center, retrospective, observational study fever with influenza-like symptoms...
Background and Objective: As bronchopulmonary dysplasia (BPD) can lead to considerable mortality morbidity, this disease is the focus of attention in neonatology. Vitamin D (VD) , which has anti-inflammatory properties promotes lung growth, may have a therapeutic effect on BPD. Neutrophil extracellular traps (NETs) overexpression were demonstrated be involved pathogenesis BPD our previous study. This study aimed elucidate VD role NETs process. Methods: Newborn rats exposed 90% oxygen...
Abstract: Ureaplasma parvum (U. parvum) is common commensal in the female genitourinary tract. Despite U. has been associated with chorioamnionitis, abortion, prematurity and perinatal complications, invasive central nervous system (CNS) infection rare neonates. Diagnosis of meningitis can be difficult for atypical presentations sterile cultures by conventional methods. Metagenomic next-generation sequencing (mNGS) could identify a broad range human pathogens target-independent manner. Here,...
Abstract Background Patients with salt-sensitive hypertension are often accompanied severe renal damage and accelerate to end-stage disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21) has been shown suppress nephropathy in both type 1 2 diabetes mice. Here, we aimed investigate the therapeutic effect of FGF21 hypertension-induced nephropathy. Methods Changes expression deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mice were detected. The...
Objective: To investigate the effect of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on lipopolysaccharide (LPS)-induced inflammatory response and oxidative stress in neonatal rat brain. Methods: Ninety-six 3-day-old Sprague Dawley rats were divided into four groups: control (saline/saline), LPS/ω-3, LPS/ω-6, LPS/saline (n = 24/group). All rats, except those group, treated with ω-3 PUFAs, ω-6 or saline at 15 ml/kg for 1 5 consecutive days following intraperitoneal LPS-challenge (0.6...
Background:: Mesenchymal stem cell-derived exosomes (MSC-Exos) therapies have shown prospects in preclinical models of pathologies relevant to neonatal medicine, such as bronchopulmonary dysplasia (BPD). Adipose-derived cells (ADSCs) been recognized one the most promising cell sources. Autophagy plays a key role regulating intracellular conditions, maintaining growth and development, participating pathogenesis BPD. Objectives:: To investigate potential therapeutic ADSC-Exos on BPD illustrate...
Abstract To detect the changes in liver function both male and female OVE26 mice from young to adults for better understanding of type 1 diabetes‐induced hepatic changes, wild‐type FVB were raised same environment without any intervention, then killed at 4, 12, 24 36 weeks examining liver's general properties, including pathogenic molecular changes. The influence diabetes on bodyweight was different. Both did not obtain serious injury or non‐alcoholic fatty disease, manifested by mild...
Abstract Background Succinate‐CoA ligase/synthetase (SCS) deficiency is responsible for encephalomyopathy with mitochondrial DNA depletion and mild methylmalonic aciduria. Variants in SUCLG1 , the nuclear gene encoding alpha subunit of SCS enzyme playing a pivotal role maintaining mtDNA integrity stability, are associated syndrome 9 (MTDPS9). Methods In this study, we reported an infant clinical features MTDPS9 from China. Whole exome sequencing (WES) was used to identify genetic cause....
Background: Macrosomia is a common disorder that occurs during pregnancy. We investigated the comprehensive metabolite profiles of pregnant maternal and fetal sera in normoglycemic macrosomia Chinese population. Methods: Forty women their fetuses were included study (twenty patients twenty normal-weight controls). Maternal umbilical cord serum metabolites identified using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Results: In total, 203 identified. Lipids...
Abstract Purpose We aimed to explore the value of Routine blood parameters, such as lymphocyte (LYM) count, platelet (PLT) lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte (NLR), LYM*PLT and mean volume-to-platelet (MPV/PLT), are widely used predict prognosis infectious diseases, for predicting influenza virus infection in children. Methods conducted a single-center, retrospective, observational study on fever with influenza-like symptom pediatric outpatients different age groups...
Diabetes-induced oxidative stress is one of the major contributors to dysfunction endothelial progenitor cells (EPCs) and impaired regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis a hind limb ischemia (HLI) model MT transgenic (JTMT) mice with high fat diet streptozocin-induced diabetes. Compared littermate wild-type (WT) diabetic mice, JTMT had improved blood flow recovery after HLI. Similarly, transplantation bone...