A5023875486- Treatment of Major Depression
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Childhood Cancer Survivors' Quality of Life
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Electroconvulsive Therapy Studies
- Kruppel-like factors research
- Industrial Vision Systems and Defect Detection
- Fibroblast Growth Factor Research
- Transcranial Magnetic Stimulation Studies
- Child and Adolescent Health
- Child Abuse and Trauma
- Family Support in Illness
- Maternal and Perinatal Health Interventions
- Vagus Nerve Stimulation Research
- Image Enhancement Techniques
- Attachment and Relationship Dynamics
- Diabetes Management and Education
Wenzhou Medical University
2025
National Clinical Research
2025
Capital Medical University
2011-2024
Beijing Anding Hospital
2011-2024
Beihua University
2023-2024
Beijing Chao-Yang Hospital
2016
Chinese Institute for Brain Research
2015
Capital University
2013-2014
Background While oral antidepressants reach efficacy after weeks, single-dose intravenous (i.v.) ketamine has rapid, yet time-limited antidepressant effects. We aimed to determine the and safety of i.v. augmentation escitalopram in major depressive disorder (MDD). Method Thirty outpatients with severe MDD (17-item Hamilton Rating Scale for Depression total score ⩾24) were randomized 4 weeks double-blind treatment 10 mg/day+single-dose (0.5 mg/kg over 40 min) or mg/day + placebo (0.9%...
Background Most knowledge regarding the effects of antidepressant drugs is at receptor level, distal from nervous system that mediate their clinical efficacy. Using functional magnetic resonance imaging (fMRI), this study investigated escitalopram, a selective serotonin reuptake inhibitor (SSRI), on resting-state brain function in patients with major depressive disorder (MDD). Method Fourteen first-episode drug-naive MDD completed two fMRI scans before and after 8 weeks escitalopram therapy....
Background. Despite substantial research, uncertainty remains about the clinical and etiological heterogeneity of major depression (MD). Can meaningful valid subtypes be identified would they stable cross-culturally? Method. Symptoms at their lifetime worst depressive episode were assessed structured psychiatric interview in 6008 women Han Chinese descent, age ⩾30 years, with recurrent DSM-IV MD. Latent class analysis (LCA) was performed Mplus. Results. Using nine MD symptomatic A criteria,...
Background The symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature this important psychiatric syndrome? Method Symptoms at lifetime worst depressive episode were assessed structured interview in 6008 women Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor (CFA) performed Mplus random split-half samples. Results preliminary EFA results consistently...
Individuals with early-onset depression may be a clinically distinct group particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in Han Chinese population.We examined the clinical features of 1970 women DSM-IV major depressive disorder (MDD) between 30 60 years age across China. Analysis linear, logistic multiple regression models was used to determine association at onset (AAO) continuous, binary discrete...
Studies conducted in Europe and the USA have shown that co-morbidity between major depressive disorder (MDD) anxiety disorders is associated with various MDD-related features, including clinical symptoms, degree of familial aggregation socio-economic status. However, few studies investigated whether these patterns association vary across different co-morbid disorders. Here, using a large cohort Chinese women recurrent MDD, we examine prevalence features disorders.A total 1970 female MDD...
Post partum depression (PPD) is relatively common in China but its clinical characteristics and risk factors have not been studied. We set out to investigate whether known for PPD could be found Chinese women.A case control design was used determine the impact of a cohort 1970 women with recurrent DSM-IV major depressive disorder (MDD). In within-case we examined patients MDD. compared features MDD cases those without Odds ratios were calculated using logistic ordinal regression.Lower...
As the UAV(Unmanned Aerial Vehicle) carrying target detection algorithm in transmission line insulator inspection, we propose a lightweight YOLOv7 defect for problems of inferior speed and high model complexity. Firstly, DSC-SE module is designed using DSC(Depthwise Separable Convolution) fused SE channel attention mechanism to substitute SC(Standard backbone extraction network decrease number parameters as well strengthen shallow network’s ability obtain information about features. Then,...
Improving wind power generation efficiency and lowering maintenance operational costs are possible through the early efficient diagnosis repair of surface defects in turbines. To solve lightweight deployment difficulty insufficient accuracy issues traditional detection methods, this paper proposes a high-precision PC-EMA block based on YOLOv8 using partial convolution (PConv) combined with an multiscale attention (EMA) channel mechanism, which replaces bottleneck layer backbone network to...
Background Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his triad and other clinical features risk factors among those with major depression (MD) has rarely been systematically studied. Method The three key symptoms worthlessness, hopelessness helplessness were assessed during their lifetime worst episode in 1970 Han Chinese women recurrent MD. Diagnostic factor information was at personal interview. Odds ratios (ORs)...
Background and objectives: Patients with treatment-resistant depression (TRD) show no improvement after treatment a series of drugs. Previous reports have described positive effects vagus nerve stimulation (VNS) on the emotional states patients epilepsy. VNS for TRD has not been explored in China. We will investigate efficacy safety Chinese cohort. Design: A pilot self-controlled trial. Methods: The study population comprise 10 consecutive admitted to Beijing Anding Hospital at Capital...