Jian Hu

ORCID: 0000-0003-1637-9708
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About
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Research Areas
  • Folate and B Vitamins Research
  • Liver Disease Diagnosis and Treatment
  • Cardiac Valve Diseases and Treatments
  • Cancer, Lipids, and Metabolism
  • Tissue Engineering and Regenerative Medicine
  • Spine and Intervertebral Disc Pathology
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Maternal Mental Health During Pregnancy and Postpartum
  • HIV-related health complications and treatments
  • Inflammatory Biomarkers in Disease Prognosis
  • Atmospheric chemistry and aerosols
  • Congenital heart defects research
  • Child and Adolescent Psychosocial and Emotional Development
  • Tryptophan and brain disorders
  • Hormonal Regulation and Hypertension
  • Mechanical Circulatory Support Devices
  • Air Quality and Health Impacts
  • Angiogenesis and VEGF in Cancer
  • Gestational Diabetes Research and Management
  • Atmospheric aerosols and clouds
  • Infective Endocarditis Diagnosis and Management
  • Immunotoxicology and immune responses
  • Glutathione Transferases and Polymorphisms
  • Osteoarthritis Treatment and Mechanisms
  • Potassium and Related Disorders

Wannan Medical College
2023-2024

South China Normal University
2024

Wuhan University
2024

Chinese PLA General Hospital
2013-2023

Shanxi Normal University
2023

Taiyuan Normal University
2023

Xiangya Hospital Central South University
2021

Central South University
2021

China Medical University
2003-2019

First Hospital of China Medical University
2019

This study assesses the effect of occupational exposure to specific chemicals on risk renal cell carcinoma in Canada. Mailed questionnaires were used obtain data 1279 (691 male and 588 female) newly diagnosed, histologically confirmed cases 5370 population controls eight Canadian provinces, between 1994 1997. Data collected socio‐economic status, smoking habit, alcohol use, diet, residential histories, years any 17 chemicals. Odds ratios (ORs) 95% confidence intervals (CIs) derived using...

10.1093/occmed/52.3.157 article EN Occupational Medicine 2002-05-01

Abstract Background This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. Methods A total 480 subjects with mild or moderate essential hypertension were randomly assigned three treatment groups: 1) enalapril only (10 mg, control...

10.1186/1475-2891-11-2 article EN cc-by Nutrition Journal 2012-01-10

Objective To investigate the change in plasma apelin level patients with stable angina. Methods The study enrolled 96 angina as Stable Angina Group and another 78 outpatients no Control Group. Subjects were excluded if they had a history of acute coronary syndrome, rheumatic heart disease, cardiomyopathy, cardiac arrhythmia, diabetes mellitus, hyperthyroidism, or antecedent hypertension. Plasma levels all subjects determined using commercially available immunoassay. In addition, blood was...

10.2169/internalmedicine.47.1287 article EN other-oa Internal Medicine 2008-01-01

Objectives To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on change serum folate concentration in response to different dosages durations folic acid (FA) supplementation hypertensive Chinese adults. Methods A total 480 patients with mild or moderate essential hypertension were randomly assigned three treatment groups: (a) enalapril only (10 mg, control group); (b) FA tablet [10 : 0.4 mg combined FA), low-FA...

10.1097/fpc.0b013e32834ac5e8 article EN Pharmacogenetics and Genomics 2011-10-04

Percutaneous valve replacement was recently introduced, and reports of early clinical experience have already been published. To date, this technique is limited to the pulmonary aortic valves in a strictly selected group patients. The aim study analyse self-expanding valved stent for minimally invasive mitral animals.A newly designed nitinol specially experimental acute study. It comprised left ventricular tubular with star shaped atrial anchoring springs carried trileaflet bovine...

10.1016/j.ejcts.2009.02.037 article EN European Journal of Cardio-Thoracic Surgery 2009-04-27

Abstract Psoriasis is a chronic inflammatory autoimmune disease with undefined etiology. All present treatments are symptomatic. The unsatisfactory outcome in the treatment of psoriasis partially due to poor compliance therapies more or less side‐effects. As known, drug homologous food popular intervention some diseases C hinese traditional medicine. Mustard seed, consumed largely as spice and medicine hina, has recently been found possess bioactivities anti‐oxidation, anti‐inflammation...

10.1111/1346-8138.12119 article EN The Journal of Dermatology 2013-05-19

Shikonin is a naphthoquinone compound extracted from the Chinese herb purple gromwell. has broad antibacterial, anti-inflammatory, and antitumor activities. The tumor necrosis factor-α (TNF-α)-induced proliferation invasion of vascular smooth muscle cells (VSMCs) an important factor that contributes to atherosclerosis. effects shikonin on apoptosis VSMCs have been reported; however, function TNF-α-mediated growth during atherosclerosis remains unclear. In this study, we used Western blot,...

10.1139/cjpp-2014-0464 article EN Canadian Journal of Physiology and Pharmacology 2015-03-18

Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF thought to cause recurrent postoperative pain after Resveratrol has been shown exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was investigate effects resveratrol on prevention postlaminectomy formation in laminectomy rats. A controlled double-blinded performed 60 healthy adult Sprague-Dawley rats that lumbar at L1-L2...

10.1155/2014/574236 article EN cc-by Evidence-based Complementary and Alternative Medicine 2014-01-01

Abstract Background Although both the patterns and accumulation of multimorbidity are important for predicting physical function, studies have not simultaneously examined their impact on functional decline. This study aimed to associate subsequently developed conditions with longitudinal trajectories decline, it tested whether effects newly decline varied across distinct patterns. Methods We included 6 634 participants aged at least 60 years from China Health Retirement Longitudinal Survey....

10.1093/gerona/glab384 article EN The Journals of Gerontology Series A 2021-12-24

The treatment effects of spironolactone on heart failure with reduced (HFrEF LVEF <40%) and preserved (HFpEF ≥50%) ejection fraction are well characterized. It is not clear whether patients mid-range (HFmrEF, 40-49%) benefit from spironolactone. present study aims to evaluate the efficacy in HFmrEF patients.This compared a high dosage (50 mg daily), low (25 an untreated group for prevention major adverse cardiovascular events (MACE) 279 admitted hospital diagnosed HFmrEF.With mean follow-up...

10.1080/03007995.2018.1520695 article EN Current Medical Research and Opinion 2018-09-05

Background Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his triad and other clinical features risk factors among those with major depression (MD) has rarely been systematically studied. Method The three key symptoms worthlessness, hopelessness helplessness were assessed during their lifetime worst episode in 1970 Han Chinese women recurrent MD. Diagnostic factor information was at personal interview. Odds ratios (ORs)...

10.1017/s0033291713000160 article EN cc-by Psychological Medicine 2013-02-21

This study aimed to investigate the relationship between fasting plasma glucose (FPG) and human serum albumin (HSA) in a large health checkup population China.In this cross-sectional study, we enrolled of 284,635 subjects from Wuhu 2011 2016. All participants completed physical examination, blood biochemical routine examination.The prevalence diabetes men women was 6.11% 2.98%, respectively. The average level HSA FPG significantly higher than (48.44 ± 3.25 vs. 47.14 3.22, P < 0.0001; 5.50...

10.1186/s12902-023-01441-z article EN cc-by BMC Endocrine Disorders 2023-09-11

Objective: Involutional entropion in the lower eyelid is one of most common disorders elderly. Despite effectiveness widely used surgical procedures, recurrence rates have failed to improve. In this retrospective study, we aimed assess plans, and safety tailored surgery based on mechanical balance principal treating involutional eyelid. Methods: A analysis 47 patients (54 eyelids) diagnosed with receiving treatment principle from 1 January 2016 31 December 2018 was carried out. Tailored...

10.1177/1120672120984398 article EN European Journal of Ophthalmology 2020-12-24

<h3>Objectives</h3> This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults <h3>Methods</h3> A total 480 subjects with mild or moderate essential hypertension were randomly assigned three treatment groups: (1) enalapril only (10 mg,...

10.1136/heartjnl-2012-302920c.8 article EN Heart 2012-10-01
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