A5100393361- Cytomegalovirus and herpesvirus research
- Autophagy in Disease and Therapy
- Ocular Diseases and Behçet’s Syndrome
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Mathematical and Theoretical Epidemiology and Ecology Models
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Retinal Diseases and Treatments
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Extraction and Separation Processes
- Viral Infections and Immunology Research
- Aerogels and thermal insulation
- Metal Extraction and Bioleaching
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Advanced Cellulose Research Studies
- HIV/AIDS drug development and treatment
- Toxoplasma gondii Research Studies
- Chronic Disease Management Strategies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health disparities and outcomes
Fujian Agriculture and Forestry University
2025
Guiyang College of Traditional Chinese Medicine
2025
Guizhou University
2025
Jinzhou Central Hospital
2022-2024
East China University of Science and Technology
2023-2024
Nankai University
2023-2024
State Key Laboratory of Medicinal Chemical Biology
2024
Central South University
2021-2024
Yan'an University
2024
Air Force Medical University
2024
Sickle cell disease is characterized by the painful recurrence of vaso-occlusive events. Gene therapy with use LentiGlobin for sickle (bb1111; lovotibeglogene autotemcel) consists autologous transplantation hematopoietic stem and progenitor cells transduced BB305 lentiviral vector encoding a modified β-globin gene, which produces an antisickling hemoglobin, HbAT87Q.
The prediction system EpiSIX was used to study the COVID-19 epidemic in mainland China between November 2022 and January 2023, based on reported data from December 9, 2022, 30, released by Chinese Center for Disease Control Prevention February 1, 2023. Three kinds of were model fitting: daily numbers positive nucleic acid tests deaths, number hospital beds taken patients. It estimated that overall infection rate 87.54% case fatality 0.078%-0.116% (median 0.100%). Assuming a new outbreak...
This review aimed to summarize research progress regarding congenital cytomegalovirus (cCMV) infection-related nervous system diseases and their mechanisms.All literature quoted in this was retrieved from PubMed Web of Science using the keywords "Cytomegalovirus" "Neurologic disease" English. To identify more important information, we did not set time limits.Relevant articles were selected by carefully reading titles abstracts. Then, different diagnosis clinical treatment methods for human...
The World Health Organization (WHO) declared monkeypox as a public health emergency of international concern (PHEIC) on July 23, 2022, their highest level alert. This raised concerns about the management global outbreak, well scientific analysis and accurate prediction future course epidemic. study used EpiSIX (an system for epidemics based general SEIR model) to analyze epidemic forecast major tendencies data from USA CDC (https://www.cdc.gov) WHO...
Treatment of HCV genotype 1b (GT1b)-infected Japanese patients with paritaprevir (NS3/4A inhibitor boosted ritonavir) and ombitasvir (NS5A inhibitor) in studies M12-536 GIFT-I demonstrated high sustained virologic response (SVR) rates. The failure rate was 3% (13/436) across the two studies. Analyses were conducted to evaluate impact baseline resistance-associated variants (RAVs) on treatment outcome emergence persistence RAVs experiencing failure. Baseline resistance-conferring NS3...
A COVID-19 outbreak in the rural areas of Shijiazhuang City was attributed to complex interactions among vaccination, host, and non-pharmaceutical interventions (NPIs). Herein, we investigated epidemiological characteristics all reported symptomatic cases by picking City, Hebei Province Northern China as research objective. In addition, established a with age-group mathematical model perform optimal fitting investigate dynamical profiles under three scenarios.All epidemic (January 2-February...
Objective This study used two sample Mendelian randomization (MR) method to evaluate the causal relationship between tonsillectomy and irritable bowel syndrome (IBS). Methods We selected as exposure factor IBS outcome variable, using GWAS data from IEU Open project. Instrumental variables (IVs) were SNPs strongly correlated independent of tonsillectomy. MR-PRESSO was for outlier removal. IVW primary MR analysis method, supplemented by MR-Egger regression, WM, WME, simple mode. Cochran's Q...
Abstract Phosphorus (P) deficiency is critical to the renewal barrier of she-oak (Casuarina equisetifolia), an important tree species used for coastal protection. However, response P remains unclear. In this study, we compared phenotypes two cultivars, deficiency-sensitive ‘Chihu219’ and insensitive ‘Chihu397’, found that significantly increased root growth, concentration absorption efficiency (PAE) in Chihu219, but not Chihu397. We also analyzed transcriptome metabolome these cultivars...
The complex interactions were performed among non-pharmaceutical interventions, vaccinations, and hosts for all epidemics in mainland China during the spread of COVID-19. Specially, small-scale epidemic city described by SVEIR model was less found current studies. with control established to analyze dynamical epidemiological features two Jinzhou City led Omicron variants before after Twenty Measures. In this study, total population (N) divided into five compartments: susceptible (S),...
Interferon tau (IFNT), a pregnancy recognition signal in ruminants, promotes the establishment of embryo implantation by inducing expression interferon-stimulated genes (ISGs) via Janus kinase/signal transducer and activator transcription (JAK/STAT) signaling pathway. However, precise regulatory mechanism IFNT goat remains largely unknown. In this study, we performed RNA sequencing endometrial epithelial cells (gEECs) with or without 20 ng/mL treatment. Differential comparison showed that...
The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression cervical lesions. Previous studies that did not consider physical status HPV may have incorrectly mapped methylomes. In order identify reliable biomarkers for squamous cancer (SCC), we comprehensively evaluated depending on integration incidence each sample. Based 115 16-infected patients (50 SCC, 30 high-grade intraepithelial lesion [HSIL], and 35 low-grade [LSIL]) Caski cell lines...
Chang-wei-qing (CWQ) is a Chinese herbal recipe with clinical efficacy. However, the molecular mechanism underlying its recognized therapeutic benefits against colorectal cancer still elusive.To investigate potential beneficial effects of CWQ in drug-induced colitis-associated (CAC) model and mechanistic involvements this disease.Colitis-associated was induced by azoxymethane (AOM) dextran sulphate sodium (DSS). administrated gavage. Colon length tumour size were determined after resection....
Cytomegalovirus (CMV) induced autophagy affects virus replication and survival of the infected cells. The purpose this study was to investigate role inhibition by 3-methyladenine (3-MA) on murine cytomegalovirus (MCMV) whether it is associated with caspase-3 dependent apoptosis. eyecup isolated from adult C57BL/6J mice (6-8 weeks old) mouse embryo fibroblast cells (MEFs) were MCMV K181 strain, followed treatment (3-MA), chloroquine, or rapamycin block stimulate autophagy. In cultured MEFs,...
Pregnancy, a complex biological phenomenon, relies on intricate maternal-fetal interactions for success. Decidual natural killer (dNK) cells and trophoblasts are pivotal in establishing immune tolerance at the interface. The chemokine receptor CXCR4 plays crucial role NK cell development during early placental development.Primary decidual from 42 women with normal pregnancies 20 patients experiencing recurrent spontaneous abortions (RSAs) were studied. Gene transcription was assessed using...
Abstract Purpose This study aims to explore the incidence of hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and influence on specific quality life T2DM patients. Methods It was a comparative cross-sectional consisting 519 Xi'an, China were investigated by self-reported questionnaires from September 2019 January 2020. Descriptive analysis, t -test, Chi-square test, hierarchical regression analysis stepwise multiple applied assess life. Results The 32.18%. mean score without...
This study aimed to identify long-term distinct trajectories of multimorbidity with ageing from 50 85 years among Chinese older adults and examine the relationship between exposure early-life adversity (ELA; including specific types accumulation different adversities) these trajectories. The group-based trajectory models identified Multinomial logistic regression were used ELA data China Health Retirement Longitudinal Study (CHARLS, 2011-2018) 2014 Life History Survey. We 9112 respondents...