A5100400450- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Neurogenesis and neuroplasticity mechanisms
- Fungal Infections and Studies
- Viral Infections and Vectors
- Ferroptosis and cancer prognosis
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Phytochemistry and Biological Activities
- Cytomegalovirus and herpesvirus research
- Malaria Research and Control
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Metal-Catalyzed Oxygenation Mechanisms
- Hormonal and reproductive studies
- Amoebic Infections and Treatments
- Menstrual Health and Disorders
- Per- and polyfluoroalkyl substances research
- Allergic Rhinitis and Sensitization
Capital Medical University
2008-2024
Hainan Medical University
2024
Beijing YouAn Hospital
2012-2024
Chinese PLA General Hospital
2024
Xuan Wu Hospital of the Capital Medical University
2010-2024
First Affiliated Hospital of Wannan Medical College
2023-2024
Second Hospital of Anhui Medical University
2023
Wannan Medical College
2023
Tianjin University of Technology
2023
Anhui Medical University
2023
Hantaviruses are among the most important zoonotic pathogens of humans and subject heightened global attention. Despite importance hantaviruses for public health, there is no consensus on their evolutionary history especially frequency virus-host co-divergence versus cross-species virus transmission. Documenting extent hantavirus biodiversity, particularly range mammalian hosts, critical to resolving this issue. Here, we describe four novel (Huangpi virus, Lianghe Longquan Yakeshi virus)...
Purpose Ongoing Monkeypox (MPX) outbreaks in countries outside Africa have unique characteristics. However, data on cohorts of confirmed cases China is limited. The study provides important epidemiological, diagnostic, and clinical information about this disease China. Methods We report a series Chinese individuals with MPX infections identified at Beijing Youan Hospital (China) from June 10 to July 15, 2023. Samples were taken the skin, anus, throat, blood. An epidemiological questionnaire...
The development of an effective vaccine is critical for prevention a Middle East respiratory syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor-binding domain (RBD) protein MERS-CoV spike (S) good candidate antigen subunit vaccine. However, highly purified proteins are typically not inherently immunogenic. We hypothesised that humoral and cell-mediated immunity would be improved with modification vaccination regimen. Therefore, immunogenicity novel RBD-based...
Artemisinin, a traditional Chinese medicine with remarkable antimalarial activity. In recent years, studies demonstrated that artemisinin and its derivatives (ARTs) showed anti-inflammatory immunoregulatory effects. ARTs have been developed gradually applied to treat autoimmune inflammatory diseases. However, their role in the treament of patients diseases particular is less well recognized. This review will briefly describe history use diseases, theorized mechanisms action agents ARTs,...
Metformin (Met) is the recommended first-line therapeutic drug for type 2 diabetes mellitus (T2DM) and exerts protective effects on β-cell damage. Ferroptosis, a new form of cell death, associated with pancreatic islet injury in patients T2DM. However, Met treatment against damage through ferroptosis modulation remain under-reported. This study investigated vivo using two different diabetic mouse models, namely, low-dose streptozotocin (STZ) high-fat diet (HFD)-induced mice db/db mice....
ABSTRACT Objective We aimed to evaluate the differences in clinical features and lifestyle between Han ethnic minority populations Guangdong Province, China their impacts on ever‐growing burden of metabolic dysfunction‐associated steatotic liver disease (MASLD). Methods In this cross‐sectional investigation China, one most densely populated areas with imbalanced development, multistage stratified random sampling was used. Demographic, socioeconomic, data participants were collected....
Neuroimaging is a cornerstone in the diagnosis and treatment decision-making for brain acute ischemic stroke. A rapid accurate key, specifically time-critical reperfusion therapies. Successful of salvageable penumbra can reduce extent stroke thus improve clinical outcomes, whereas irreversibly affected tissue thought to be futile may result harm due risk hemorrhagic transformation. For neuroimaging work-up stroke, computed tomography (CT) more commonly applied than magnetic resonance imaging...
High levels of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), which is a substitute for perfluorooctane (PFOS), are detected in various environmental matrices, wildlife, and humans. Chlorinated has received increased attention due to its potential risk ecosystems. However, toxicity the soil organisms remains unclear. In present study, comparative investigation was conducted on toxicities (F-53B) PFOS earthworm Eisenia. fetida. F-53B significantly more acutely toxic earthworms than...
Purpose: This work aimed to study the effect of posterior scleral reinforcement (PSR) on choroidal thickness (CT) and blood flow. Methods: included 25 eyes 24 patients with high myopia ( ≤ -6.0 dioptres or axial length ≥ 26.0 mm) who underwent PSR surgery. All completed 1-month follow-up visit. Myopic macular degeneration (MMD) was graded according International Meta-Analysis for Pathologic Myopia (META-PM) classification based color fundus photographs. Swept-source optical coherence...
Chikungunya fever is an acute infectious disease that mediated by the mosquito-transmitted chikungunya virus (CHIKV), for which no licensed vaccines are currently available. Here, we explored several immunization protocols and investigated their immunity protective effects in mice, with DNA- virus-like particle (VLP)- vaccines, both alone combination. Both DNA VLP vaccine candidates were developed characterized, express CHIKV structural genes (C-E3-E2-6K-E1). Mice immunized twice, different...
Oxidized low-density lipoprotein (oxLDL) promotes expression and secretion of endothelin-1 (ET-1), however, the precise mechanism involved is unclear. This study was designed to identify regulatory oxLDL-induced ET-1 in endothelial cells.ET-1 mRNA expression, promoter activity were evaluated by reverse transcriptase-PCR (RT-PCR), enzyme immunometric luciferase assays, respectively.oxLDL (35 microg/ml) significantly enhanced reactive oxygen species (ROS), human umbilical vein cells (HUVECs),...
Abstract In 2014, 20 dengue cases were reported in the cities of Wenzhou (5 cases) and Wuhan (15 cases), China, where has rarely been reported. Dengue virus 1 was detected 4 patients. Although most these likely imported, epidemiologic analysis provided evidence for autochthonous transmission.
Abstract Deep brain stimulation (DBS) has been tentatively explored to promote motor recovery after stroke. Stroke could transiently activate endogenous self-repair processes, including neurogenesis in the subventricular zone (SVZ). In this regard, it is of considerable clinical interest study whether DBS lateral cerebellar nucleus (LCN) SVZ for functional present study, rats were trained on pasta matrix reaching task and ladder rung walking before surgery. And then an electrode was...
Neurogenesis, play a vital role in neuronal plasticity of adult mammalian brains, and its dysregulation is present the pathophysiology Parkinson's disease (PD). While subthalamic nucleus deep brain stimulation (STN-DBS) at various frequencies has been proven effective alleviating PD symptoms, influence on neurogenesis remains unclear. This study aimed to investigate effects 1-week electrical 60Hz, 130Hz, 180Hz subventricular zone (SVZ) rats. A hemiparkinsonian rat model was established using...
Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor (MDSCs) are known to be involved in chronic acute inflammatory conditions. In this study, we aimed characterize the function MDSCs improve understanding, prevention treatment CE. Our results indicated that overexpressing Ly6C Ly6G...