A5011108322- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Mental Health Research Topics
- Genomics and Rare Diseases
- Chromosomal and Genetic Variations
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Neuroendocrine regulation and behavior
- Emotion and Mood Recognition
- Cancer-related gene regulation
- Receptor Mechanisms and Signaling
- Gene expression and cancer classification
University of California, Los Angeles
2016-2024
Neurobehavioral Systems
2016-2024
Robert Jones and Agnes Hunt Orthopaedic Hospital
2024
Olive View-UCLA Medical Center
2024
East China Normal University
2015-2023
Yale University
1999-2022
Centre for Human Genetics
2009-2018
University of Oxford
2009-2018
East London NHS Foundation Trust
2018
State University of New York
2018
We report genome sequences of 17 inbred strains laboratory mice and identify almost ten times more variants than previously known. use these genomes to explore the phylogenetic history mouse examine functional consequences allele-specific variation on transcript abundance, revealing that at least 12% transcripts show a significant tissue-specific expression bias. By identifying candidate 718 quantitative trait loci we molecular nature their position relative genes vary according effect size...
<b><i>Objective:</i></b> To make evidence-based recommendations concerning the evaluation of child with a nonprogressive global developmental delay. <b><i>Methods: </i></b> Relevant literature was reviewed, abstracted, and classified. Recommendations were based on four-tiered scheme evidence classification. <b><i>Results: Global delay is common affects 1% to 3% children. Given yields about 1%, routine metabolic screening not indicated in initial Because higher yield (3.5% 10%), even absence...
Mutations in whole organisms are powerful ways of interrogating gene function a realistic context. We describe program, the Sanger Institute Mouse Genetics Project, that provides step toward aim knocking out all genes and screening each line for broad range traits. found hitherto unpublished were as likely to reveal phenotypes known genes, suggesting novel represent rich resource investigating molecular basis disease. many unexpected detected only because we screened them, emphasizing value...
High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected crosses between inbred strains are often caused by numerous linked QTLs, each small effect. In a study fearfulness mice, we have shown it is possible fine map small-effect QTLs genetically heterogeneous stock (HS). This strategy powerful general method provided that formed HS can reliably HS. We show here single-marker association analysis identifies only two...
Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little common. Emotionality mice is such a trait, defined here by activity and defecation novel environment emergence into the open arms an elevated plus maze. Behavioral quantitative trait analyses were conducted on four obtained 879 F2 intercross. Three loci, murine chromosomes 1, 12, 15, mapped influence emotionality. This studies strain, sex, individual differences...
We compare and contrast the genetic architecture of quantitative phenotypes in two genetically well-characterized model organisms, laboratory mouse, Mus musculus , fruit fly, Drosophila melanogaster with that found our own species from recent successes genome-wide association studies. show current large numbers loci, each small effect, is true for all examined, discrepancies can be largely explained by differences experimental designs used. argue distribution effect size common variants same...
The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect migration result abnormal lamination structures with associated behavioral deficits. Here, we report identification a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant abnormalities laminar architecture hippocampus cortex, accompanied by impaired We show causative mutation lies guanosine triphosphate (GTP) binding pocket α-1 tubulin (Tuba1) affects...