A5042955855- LGBTQ Health, Identity, and Policy
- Criminal Justice and Corrections Analysis
- Social Policy and Reform Studies
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Law in Society and Culture
- Homelessness and Social Issues
- Antibiotic Use and Resistance
- Gender, Security, and Conflict
- Microbial Metabolism and Applications
- Feminism, Gender, and Sexuality Studies
- Gender Politics and Representation
- Housing, Finance, and Neoliberalism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Bacterial biofilms and quorum sensing
- Chromosomal and Genetic Variations
- Genetic Associations and Epidemiology
- Korean Peninsula Historical and Political Studies
- African Sexualities and LGBTQ+ Issues
- Genomic variations and chromosomal abnormalities
- Bacillus and Francisella bacterial research
- Economic theories and models
- Cancer Genomics and Diagnostics
Birkbeck, University of London
2009-2024
Centre for Human Genetics
2012-2021
University of Oxford
2012-2021
German Cancer Research Center
2017
Imperial College London
2017
Genomics (United Kingdom)
2017
Heidelberg University
2017
Universidad de Londres
2011-2014
Keele University
2009
University of Kent
2008-2009
Some of the most common infectious diseases are caused by bacteria that naturally colonise humans asymptomatically. Combating these opportunistic pathogens requires an understanding traits differentiate infecting strains from harmless relatives. Staphylococcus epidermidis is carried asymptomatically on skin and mucous membranes virtually all but a major cause nosocomial infection associated with invasive procedures. Here we address underlying evolutionary mechanisms pathogenicity combining...
The Nextera protocol, which utilises a transposome based approach to create libraries for Illumina sequencing, requires pure DNA template, an accurate assessment of input concentration and column clean-up that limits its applicability high-throughput sample preparation. We addressed the identified limitations develop robust workflow supports both rapid projects also reducing reagent costs. show initial bead-based normalisation step can remove need quantification improves purity. A 75% cost...
The opportunistic pathogens Staphylococcus aureus and epidermidis represent major causes of severe nosocomial infection, are associated with high levels mortality morbidity worldwide. These species both common commensals on the human skin in nasal pharynx, but genetically distinct, differing at 24% average nucleotide divergence 1,478 core genes. To better understand genome dynamics these ecologically similar staphylococcal species, we carried out a comparative analysis 324 S. genomes,...
Abstract Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors. Here we use whole-genome sequencing to identify somatic mutations chromosomal changes in 14 bladder different grades stages. As well as detecting known cancer driver mutations, report identification recurrent protein-inactivating CDKN1A FAT1. The former not mutually exclusive with TP53 or MDM2...
β-III spectrin is present in the brain and known to be important function of cerebellum. Heterozygous mutations SPTBN2, gene encoding spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressive, autosomal-dominant pure cerebellar ataxia. SCA5 sometimes as "Lincoln ataxia," because largest family descended from relatives United States President Abraham Lincoln. Using targeted capture next-generation sequencing, we identified a homozygous stop codon SPTBN2...
Britain has recently gained notoriety as a global hotspot for anti-trans politics and 'gender critical' feminism. But what is the relationship between British transnational 'anti-gender' movement? Does Britain's gender critical feminism directly align with trends of anti-gender mobilisations, including latter's authoritarian neofascist tendencies? This commentary argues context-specific analysis gender-critical movement which attentive to its divergent political orientations. While some...
Although litigation involving sexual orientation and gender identity discrimination claims has generated considerable public attention in recent years, lesbian transgender bodies sexualities still remain largely invisible Anglo-American courts. While such invisibility is generally attributed to social norms that fail recognize experiences, the capacity `not see' or know' queer also involves wilful acts of ignorance. Drawing from R. v Hornick (2002) a Canadian case police raid women's...
Abstract Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with but its function in interphase not known. Here we show Repo-Man, via Nup153, enriched on condensed at the nuclear periphery edge of nucleopore basket. formation heterochromatin, dephosphorylates H3S28 it necessary sufficient for heterochromatin binding H3K27me3 recruitment. Using novel proteogenomic approach,...
Bacterial plasmids can vary from small selfish genetic elements to large autonomous replicons that constitute a significant proportion of total cellular DNA. By conferring novel function the cell, may facilitate evolution but their mobility be opposed by co-evolutionary relationships with chromosomes or encouraged via infectious sharing genes encoding public goods. Here, we explore these hypotheses through large-scale examination association between and chromosomal DNA in phenotypically...
Staphylococcus aureus are globally disseminated among farmed chickens causing skeletal muscle infections, dermatitis, and septicaemia. The emergence of poultry-associated lineages has involved zoonotic transmission from humans to but questions remain about the specific adaptations that promote proliferation chicken pathogens. We characterized genetic variation in a population genome-sequenced S. isolates poultry human origin. Genealogical analysis identified dominant sequence cluster within...
Circulating microRNAs (miRNAs) are emerging biomarkers for stroke because of their high stability in the bloodstream and association with pathophysiologic conditions. However, circulating whole-genome miRNAs (miRNome) has not been characterized comprehensively acute phase stroke.We profiled miRNome mouse models ischemic hemorrhagic by next-generation sequencing. Stroke were compared sham-operated naive mice to identify deregulated miRNAs. Top-ranked validated further quantitative reverse...
Abstract We argue that defunding the police is necessary to address fundamental and systemic problems plaguing British policing. do so in response an article written by Fleetwood & Lea (2022), published this journal, claiming ‘defunding does not translate well UK’ (p.172).
Antimicrobial resistance (AMR) in
The Welfare Reform Bill 2009 is the latest development in New Labour's ‘responsibility’ agenda.2 Based largely on commissioned reports by former investment financier David Freud (2007) and economis...
This article analyses a widely publicised case in England, where trans woman was remanded to women’s prison and subsequently sexually assaulted other women prisoners. The traces how the politically mobilised support growing backlash against rights Britain. argues that successfully deployed by trans-hostile groups because of combination carceral politics sexual exceptionalism, which cut across both left right has roots racialised narratives ‘dangerous others'. These narratives, while...