Anne E. Kiltie
A5025547057- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Urinary and Genital Oncology Studies
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Effects of Radiation Exposure
- Ferroptosis and cancer prognosis
- Carcinogens and Genotoxicity Assessment
- Urological Disorders and Treatments
- Gut microbiota and health
- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
University of Aberdeen
2021-2025
University of Oxford
2013-2024
Cancer Research UK
2007-2023
Medical Research Council
2015-2021
CRUK/MRC Oxford Institute for Radiation Oncology
2011-2021
Princess Margaret Cancer Centre
2010-2013
Ontario Institute for Cancer Research
2010-2013
University of Toronto
2013
University of Bradford
2013
St James's University Hospital
2003-2011
Abstract Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder cancer, but the choice of which treatment would be most beneficial cannot currently predicted for individual patients. The primary aim this study was to assess whether expression any a panel DNA damage signaling proteins tumor samples taken before irradiation could used as predictive marker response, or rather prognostic. Protein MRE11, RAD50, NBS1, ATM, H2AX studied by immunohistochemistry...
The aim of this prospective, phase II trial was to determine the response muscle-invasive bladder cancer (MIBC) concurrent chemoradiotherapy weekly gemcitabine with 4 weeks radiotherapy (RT; GemX).
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
Abstract Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors. Here we use whole-genome sequencing to identify somatic mutations chromosomal changes in 14 bladder different grades stages. As well as detecting known cancer driver mutations, report identification recurrent protein-inactivating CDKN1A FAT1. The former not mutually exclusive with TP53 or MDM2...
MicroRNAs (miRNAs) are involved in post-transcriptional regulation of gene expression through binding to messenger RNAs (mRNA) thereby promoting mRNA degradation or altered translation. A single-nucleotide polymorphism (SNP) located within a miRNA-binding site could thus alter translation and influence cancer risk treatment response. The common SNPs the 3′-untranslated regions 20 DNA repair genes were analysed for putative sites using bioinformatics algorithms, calculating difference Gibbs...
Abstract RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repair, and HR represents novel target for cancer therapy. Because imatinib (Gleevec) has been reported to reduce levels, we tested clonogenic survival RT112, H1299, PANC1, PC3 tumor cell lines varying p53 status normal GM05757 fibroblasts after exposure single agent (0–20 μmol/L; 0–72 hours). We also combined with damaging agents that are toxic RAD51-deficient cells, including ionizing...
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins covalently attached to DNA. Unrepaired DPCs lead genomic instability, cancer, neurodegeneration, and accelerated aging. DPC proteolysis was recently identified as specialized pathway for repair. The DNA-dependent protease SPRTN the 26S proteasome emerged two independent proteolytic systems. also repaired by homologous recombination (HR), canonical repair pathway. While studying cellular response formation, we...
Abstract Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised dietary fibre and its microbiota modification can radiosensitise via secretion metabolites and/or immunomodulation. We investigated efficacy...
We studied the outcomes in patients with node positive penile cancer who received radiotherapy to inguinal and pelvic nodes. Although half of cases are cured by lymphadenectomy, little data available on potential further benefits toxicities postoperative radiotherapy.