A5002657236- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Radiation Therapy and Dosimetry
- Breast Lesions and Carcinomas
- Bladder and Urothelial Cancer Treatments
- COVID-19 and healthcare impacts
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Bone health and treatments
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
Canary Institute of Cancer Research
2010-2025
Universidad Fernando Pessoa Canarias
2018-2025
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
Universidad de Las Palmas de Gran Canaria
2012-2024
Hospital Universitario de Gran Canaria Doctor Negrín
2009-2018
Centro Sociosanitario Nuestra Señora del Pino
1997-1998
The Netherlands Cancer Institute
1996
Hospital Materno-Infantil
1995
Universidad de Granada
1990
Abstract The European Union Radiation, Education, Staffing & Training (EU-REST) study was a Commission-funded, 24-month project that analysed workforce availability, education and training needs to ensure quality safety aspects of medical applications involving ionising radiation in the EU developed staffing education/training guidelines for key professional groups involved ensuring Member States. This article outlines origin, development, goals overall structure project. Critical...
Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2 infection. In multivariate analysis, advanced age was an independent risk factor for death. Recent studies suggest a role nucleotide-binding domain and leucine rich repeat containing family, pyrin 3 (NLRP3) inflammasome activation lung inflammation fibrosis SARS-CoV infections. Increased NLRP3/ apoptosis-associated speck-like protein (ASC) mRNA expression increased caspase-1 activity, have been observed...
The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered a respiratory disease that will progress to an acute distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop systemic inflammatory response with Cytokine Release Syndrome (CRS), characterized by sudden increase in several pro-inflammatory cytokines, mainly IL-1, IL-6 and TNF-alfa activated macrophages (M1 phenotype). Blocking tocilizumab using respirator equipment seems be very important...
•Improvement of therapeutic ratio by novel unconventional radiotherapy approaches.•Immunomodulation using high-dose spatially fractionated radiotherapy.•Boosting radiation anti-tumor effects adding an immune-mediated cell killing.
Abstract Background Numerous hypermethylated genes have been reported in breast cancer, and the silencing of these plays an important role carcinogenesis, tumor progression diagnosis. These promoters are very rarely found normal breast. It has suggested that aberrant hypermethylation may be useful as a biomarker, with implications for cancer etiology, diagnosis, management. The relationship between primary neoplasm metastasis remains largely unknown. There no comprehensive comparative study...
Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell survival. IGF-1R exerts its main actions through mitogen-activated protein phosphoinositide 3-kinase pathways. In addition to their traditional roles, has been associated with increased radioresistance both vitro vivo, although molecular mechanisms behind this process are still unclear. Recently, new partners as major...
The management of older cancer patients remains difficult because data paucity. Radiation oncologists need to identify potential issues which could affect treatment those patients. A workshop was organized in Barcelona among international radiation with special interest the on April 22, 2018. following consensus reached: 1. Older often faced unconscious discriminating bias from specialists and institutions their chronological age. 2. Advances radiotherapy techniques have allowed multiple...
We demonstrated for the first time safety and feasibility of escalating up to 55 Gy/11 Gy/fr/5fr in borderline (BRPC)/unresectable locally advanced pancreatic cancer (LAPC), using standard LINAC platform. The aim present study is assess impact this high-dose neoadjuvant stereotactic ablative radiotherapy (SABRT) protocol on tumor resectability pathological responses. From June 2017 December 2022, patients with BRPC/LAPC were treated chemotherapy (ChT) SABRT-escalated doses SIB at 45 Gy, 50...
Immune cells in primary uveal melanoma (PUM) have mostly been studied enucleated tissue, thereby precluding material from thinner, low-risk PUM tumors for research purposes. Here, we investigated the feasibility of using tumor tissue acquired by transvitreal retinochoroidal (TVRC) biopsies to study immune microenvironment and relation genetic risk class. Collected 41 patients were tested aberrations determine high-risk (n = 19), medium-risk 12), 9) digested flow cytometry analysis cell...
Tumors grow progressively when they escape from immune surveillance. Cancer progression is mainly driven by the expansion of tumor cells, but microenvironment and anti-tumor immunity may also play a role. Ionizing radiation therapy (RT), either alone or in combination with additional stimulators, can render cancer cells visible to system. In addition direct effects radiation, ensuing response promotes expression inflammatory immunostimulatory mediators, which act on neighboring,...
The coronavirus disease 19 (COVID-19) pandemic is unprecedented as it reached all countries in the world within a record short period of time. Even though COVID-19 infection may be just severe any adults, older adults (65-year-old or older) experience higher mortality rate. Among those affected, cancer patients have worse outcome compared to general population because their depressed immune status. As health resources most are limited, clinicians face painful decisions about which save if...
Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation a limiting factor for treatment success. Determination of lymphocyte radiosensitivity radio-induced apoptosis arises as possible method predictive test development. The aim this study was analyze peripheral blood lymphocytes.Ninety four consecutive patients suffering from cervical carcinoma, diagnosed in our institution, healthy controls were included the study. evaluated using Lent-Soma scale....