J. Alfred Witjes

ORCID: 0000-0003-0059-3857
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About
Contact & Profiles
Research Areas
  • Bladder and Urothelial Cancer Treatments
  • Urinary and Genital Oncology Studies
  • Prostate Cancer Diagnosis and Treatment
  • Urological Disorders and Treatments
  • Prostate Cancer Treatment and Research
  • MRI in cancer diagnosis
  • Urologic and reproductive health conditions
  • Urinary Tract Infections Management
  • Urinary Bladder and Prostate Research
  • Esophageal Cancer Research and Treatment
  • Epigenetics and DNA Methylation
  • Cancer Immunotherapy and Biomarkers
  • Colorectal Cancer Screening and Detection
  • Testicular diseases and treatments
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Research and Treatments
  • Renal cell carcinoma treatment
  • Infectious Disease Case Reports and Treatments
  • Advanced Radiotherapy Techniques
  • Multiple and Secondary Primary Cancers
  • Cancer Diagnosis and Treatment
  • Genetic factors in colorectal cancer
  • Radiopharmaceutical Chemistry and Applications
  • Ovarian cancer diagnosis and treatment
  • Immunotherapy and Immune Responses

Radboud University Nijmegen
2016-2025

Radboud University Medical Center
2016-2025

University Medical Center
2004-2023

Charles University
2023

Radboud Institute for Molecular Life Sciences
2018-2021

The Netherlands Cancer Institute
2018

European Organisation for Research and Treatment of Cancer
2016

Puigvert Foundation
2016

Jeroen Bosch Ziekenhuis
2012

Canisius-Wilhelmina Ziekenhuis
2008-2012

To retrospectively determine the relationship between apparent diffusion coefficients (ADCs) obtained with 3.0-T diffusion-weighted (DW) magnetic resonance (MR) imaging and Gleason grades in peripheral zone prostate cancer.The requirement to obtain institutional review board approval was waived. Fifty-one patients cancer underwent MR before prostatectomy, including DW b values of 0, 50, 500, 800 sec/mm(2). In prostatectomy specimens, separate slice-by-slice determinations grade groups were...

10.1148/radiol.11091409 article EN Radiology 2011-04-18

Purpose: To prospectively determine the accuracies of T2-weighted magnetic resonance (MR) imaging, dynamic contrast material–enhanced MR and quantitative three-dimensional (3D) proton spectroscopic imaging entire prostate for cancer localization, with whole-mount histopathologic section findings as reference standard. Materials Methods: This study was approved by institutional review board, informed consent obtained from all patients. Thirty-four consecutive men a mean age 60 years...

10.1148/radiol.2412051866 article EN Radiology 2006-11-01

Undetected cancer in repeat transrectal ultrasound guided prostate biopsies patients with increased specific antigen greater than 4 ng/ml is a considerable concern. We investigated the tumor detection rate of suspicious regions on multimodal 3 Tesla magnetic resonance imaging and subsequent biopsy 68 men negative biopsies. compared results to those matched population. Also, we determined clinical significance detected tumors.A total 71 consecutive 2 or sessions underwent imaging. In this was...

10.1016/j.juro.2009.10.022 article EN The Journal of Urology 2009-12-16

Abstract Purpose: Early detection of prostate cancer can increase the curative success rate for cancer. We studied diagnostic usefulness TMPRSS2-ERG fusion transcripts as well combination antigen 3 (PCA3) RNA and in urinary sediments after digital rectal examination (DRE). Experimental Design: A total 78 men with cancer–positive biopsies 30 cancer–negative were included this study. After DRE, first voided urine was collected, obtained. used semiquantitative reverse transcription-PCR (RT-PCR)...

10.1158/1078-0432.ccr-07-0700 article EN Clinical Cancer Research 2007-09-01
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