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Georgios Gakis

ORCID: 0000-0003-0995-2406
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About
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A5080662684
Research Areas
  • Bladder and Urothelial Cancer Treatments
  • Urinary and Genital Oncology Studies
  • Urological Disorders and Treatments
  • Prostate Cancer Treatment and Research
  • Renal cell carcinoma treatment
  • Urinary Bladder and Prostate Research
  • Prostate Cancer Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Urologic and reproductive health conditions
  • Cancer, Lipids, and Metabolism
  • Genital Health and Disease
  • Urinary Tract Infections Management
  • Ureteral procedures and complications
  • Esophageal Cancer Research and Treatment
  • Pediatric Urology and Nephrology Studies
  • Inflammatory Biomarkers in Disease Prognosis
  • Pelvic floor disorders treatments
  • Renal and related cancers
  • Testicular diseases and treatments
  • Bone health and treatments
  • Tissue Engineering and Regenerative Medicine
  • Cancer Genomics and Diagnostics
  • Sarcoma Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • Medical and Health Sciences Research

Klinik und Poliklinik für Urologie
 2015-2024

Martin Luther University Halle-Wittenberg
 2023-2024

University of Würzburg
 2017-2024

University Hospital in Halle
 2023-2024

LMU Klinikum
 2024

Ludwig-Maximilians-Universität München
 2009-2024

Universitätsklinikum Würzburg
 2017-2023

University Children's Hospital Tübingen
 2011-2022

Friedrich-Alexander-Universität Erlangen-Nürnberg
 2021

University of Tübingen
 2009-2019

 Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer
OPENALEX - Publications 
J. Alfred Witjes Thierry Lebrét Éva Compérat Nigel C. Cowan Maria De Santis and 10 more H.M. Bruins Virginia Hernández Estefanía Linares James Dunn Mathieu Rouanne Y. Neuzillet Erik Veskimäe Antoine G. van der Heijden Georgios Gakis María J. Ribal

10.1016/j.eururo.2016.06.020 article EN European Urology 2016-07-02
 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2013 Guidelines
OPENALEX - Publications 
J. Alfred Witjes Éva Compérat Nigel C. Cowan Maria De Santis Georgios Gakis and 4 more Thierry Lebrét María J. Ribal Antoine G. van der Heijden Amir Sherif

10.1016/j.eururo.2013.11.046 article EN European Urology 2013-12-12
 Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial
OPENALEX - Publications 
Thomas Powles Tibor Csöszi Mustafa Özgüroĝlu Nobuaki Matsubara Lajos Géczi and 95 more Susanna Cheng Yves Fradet Stéphane Oudard Christof Vulsteke Rafael Morales‐Barrera Aude Fléchon Şeyda Gündüz Yohann Loriot Alejo Rodríguez‐Vida Ronac Mamtani Evan Y. Yu Kijoeng Nam Kentaro Imai Blanca Homet Moreno Ajjai Alva D. Cascallar Mirta Varela Mauricio Fernández Lazzaro Diego Kaen Gabriela Gatica David Hugo Flores Agustín Falco Matias Molina F. Van Aelst Christof Vulsteke Brieuc Sautois Jean‐Pascal Machiels Denis Schallier Leandro Brust Liane Rapatoni Sérgio Jobim Azevedo GISELE LOPES MARINHO João Paulo Holanda Soares Carlos Dzik Jamile Almeida Silva André P. Fay Joel Gingerich Yves Fradet Cristiano Ferrario Kylea Potvin Marie Vanhuyse Mahmoud Abdelsalam Susanna Cheng Christian Caglevic Felipe Reyes José Luis Leal Francisco Francisco Carolina Ibáñez Florence Joly Brigitte Laguerre Sylvain Ladoire Aude Fléchon Delphine Topart Olivier Huillard Stéphane Oudard Marine Gross‐Goupil Stéphane Culine Yohann Loriot Gwénaëlle Gravis Peter Reichardt Margitta Retz Jan Herden David G. Pfister Carsten Ohlman Michael Stöeckle Manfred P. Wirth Anja Lorch Günter Niegisch Peter J. Goebell Martin Boegemann Axel S. Merseburger Georgios Gakis Jens Bedke Andreas Neisius Christian A. Thomas Thomas Hoefner András Telekes Judit Kósa János Révész Gyorgy Bodoky Tibor Csöszi András Csejtei Lajos Géczi Ágnes Ruzsa Zsuzsanna Kolonics József Erfán Ray McDermott Richard Bambury Avishay Sella Stephen Jay Frank Daniel Kejzman Olesya Goldman Eli Rosenbaum Avivit Peer Raanan Berger

10.1016/s1470-2045(21)00152-2 article EN The Lancet Oncology 2021-05-26
 EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer—An International Collaborative Multistakeholder Effort†
OPENALEX - Publications 
J. Alfred Witjes Marek Babjuk Joaquim Bellmunt H.M. Bruins Theo M. de Reijke and 95 more Maria De Santis Silke Gillessen Nicholas D. James Steven MacLennan Juan Palou Tom Powles María J. Ribal Shahrokh F. Shariat Theodorus H. van der Kwast Évanguelos Xylinas Neeraj Agarwal Tom J.H. Arends Aristotle Bamias Alison Birtle Peter C. Black Bernard H. Bochner M. Bolla Joost L. Boormans Alberto Bossi Alberto Briganti Iris Brummelhuis Max M. Burger Daniel Castellano Richard Cathomas Arturo Chiti Ananya Choudhury Éva Compérat Simon J. Crabb Stéphane Culine Berardino De Bari Willem de Blok Pieter De Visschere Karel Decaestecker Konstantinos Dimitropoulos José L. Domínguez-Escrig Stefano Fanti Valérie Fonteyne Mark Frydenberg Jurgen J. Fütterer Georgios Gakis B. Geavlete Paolo Gontero Bernhard Grubmüller S. Hafeez Donna E. Hansel Arndt Hartmann Dickon Hayne Ann Henry Virginia Hernández Harry W. Herr Ken Herrmann Peter Hoskin J. Huguet Barbara Alicja Jereczek‐Fossa Rob Jones Ashish M. Kamat Vincent Khoo Anne E. Kiltie S. Krege Sylvain Ladoire Pedro C. Lara Anna M. Leliveld Estefanía Linares-Espinós Vibeke Løgager Anja Lorch Yohann Loriot Richard P. Meijer Maria Carmen Mir Marco Moschini Hugh Mostafid Arndt‐Christian Müller Christoph R. Müller James N’Dow Andrea Necchi Y. Neuzillet Jorg R. Oddens Jan Oldenburg Susanne Osanto Wim J.G. Oyen Luís Pacheco‐Figueiredo Helle Pappot Manish I. Patel Bradley R. Pieters Karin Plass Mesut Remzi Margitta Retz Jonathan Richenberg Michael Rink Florian Roghmann Jonathan E. Rosenberg Morgan Rouprêt Olivier Rouvière Carl Salembier Antti Salminen Paul Sargos

10.1016/j.eururo.2019.09.035 article EN European Urology 2019-11-20
 EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees
OPENALEX - Publications 
Alan Horwich Marek Babjuk Joaquim Bellmunt H.M. Bruins Theo M. de Reijke and 95 more Maria De Santis Silke Gillessen Nicholas D. James Steven MacLennan Juan Palou Tom Powles María J. Ribal Shahrokh F. Shariat Theodorus H. van der Kwast Évanguelos Xylinas N. Agarwal T.J.H. Arends Aristotle Bamias Alison Birtle Peter C. Black Bernard H. Bochner M. Bolla Joost L. Boormans Alberto Bossi Alberto Briganti Iris Brummelhuis Max M. Burger Daniel Castellano Richard Cathomas Arturo Chiti Ananya Choudhury Éva Compérat Simon J. Crabb Stéphane Culine Berardino De Bari W. DeBlok Pieter J. L. De Visschere Karel Decaestecker Konstantinos Dimitropoulos J.L. Domínguez-Escrig Stefano Fanti Valérie Fonteyne Mark Frydenberg Jurgen J. Fütterer Georgios Gakis B. Geavlete Paolo Gontero Bernhard Grubmüller S. Hafeez Donna E. Hansel Arndt Hartmann Dickon Hayne Ann Henry Virginia Hernández H.W. Herr Ken Herrmann Peter Hoskin J. Huguet Barbara Alicja Jereczek‐Fossa Rob Jones Ashish M. Kamat Vincent Khoo Anne E. Kiltie S. Krege Sylvain Ladoire Pedro C. Lara Anna M. Leliveld Estefanía Linares-Espinós Vibeke Løgager Anja Lorch Yohann Loriot Richard P. Meijer Maria Carmen Mir Marco Moschini Hugh Mostafid Arndt‐Christian Müller C Müller James N’Dow Andrea Necchi Y. Neuzillet Jorg R. Oddens Jan Oldenburg Susanne Osanto Wim J.G. Oyen Luís Pacheco‐Figueiredo Helle Pappot Manish I. Patel Bradley R. Pieters Karin Plass Mesut Remzi Margitta Retz Jonathan Richenberg Michael Rink Florian Roghmann Jonathan E. Rosenberg Morgan Rouprêt Olivier Rouvière Carl Salembier Antti Salminen Paul Sargos

10.1093/annonc/mdz296 article EN publisher-specific-oa Annals of Oncology 2019-08-30
 Early sacral neuromodulation prevents urinary incontinence after complete spinal cord injury
OPENALEX - Publications 
Karl‐Dietrich Sievert Bastian Amend Georgios Gakis Patricia Toomey Andreas Badke and 2 more Hans-Peter Kaps Arnulf Stenzl

Abstract Background The study aim was to investigate potential influences on human nerves and pelvic organs through early implantation of bilateral sacral nerve modulators (SNMs) in complete spinal cord injury (SCI) patients during the acute bladder‐areflexia phase. Methods Ten with neurologically‐confirmed lesions (SCLs) were provided SNMs phase atonic‐detrusor muscle. Modulation achieved by two electrodes implanted into each S 3 ‐foramen. Six declined served as controls. mean follow‐up...

10.1002/ana.21814 article EN Annals of Neurology 2009-08-04
 Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial
OPENALEX - Publications 
Daniel P. Petrylak Ronald de Wit Kim N. Alexandra Drakaki Cora N. Sternberg and 95 more Hiroyuki Nishiyama Daniel Castellano Syed A. Hussain Aude Fléchon Aristotelis Bamias Evan Y. Yu Michiel S. van der Heijden Nobuaki Matsubara B. Yа. Alekseev Andrea Necchi Lajos Géczi Yen‐Chuan Ou Hasan Şenol Çoşkun Wen-Pin Su Miriam Hegemann Ivor Percent Jae‐Lyun Lee Marcello Tucci Andrey Semenov Fredrik Laestadius Avivit Peer Giampaolo Tortora Sufia Safina Xavier García del Muro Alejo Rodríguez‐Vida İrfan Çiçin Hakan Harputluoğlu Ryan C. Widau Astra M. Liepa Richard A. Walgren Oday Hamid Annamaria H. Zimmermann Katherine M. Bell‐McGuinn Thomas Powles Suet-Lai Shirley Wong Thean Hsiang Tan Elizabeth Hovey Timothy Clay Siobhan Ng Annemie Rutten Jean‐Pascal Machiels Herlinde Dumez Susanna Y. Cheng Kim Nguyen Cristiano Ferrario Lisa Sengeloev Niels Viggo Jensen Constance Thibault Brigitte Laguerre Fredrik Laestadius Florence Joly Aude Fléchon Stéphane Culine Catherine Becht Günter Niegisch Michael Stöckle Marc‐Oliver Grimm Georgios Gakis Wolfgang Schultze‐Seemann Haralabos P. Kalofonos Dimitriοs Mavroudis Christos N. Papandreou Vasilios Karavasilis Aristotelis Bamias János Révész Lajos Géczi Eli Rosenbaum Raya Leibowitz‐Amit Daniel Kejzman Avivit Peer David Sarid Giorgio V. Scagliotti Cora N. Sternberg Giampaolo Tortora Sergio Bracarda Andrea Necchi Francesco Massari Takahiro Osawa Naoto Miyajima Nobuo Shinohara Fumimasa Fukuta Chikara Οhyama Wataru Obara Shinichi Yamashita Yoshihiko Tomita Koji Kawai Satoshi Fukasawa Nobuaki Matsubara Masafumi Oyama Junji Yonese Masayoshi Nagata Motohide Uemura Kazuo Nishimura Mutsushi Kawakita Hiroyuki Tsunemori

10.1016/s0140-6736(17)32365-6 article EN The Lancet 2017-09-12
 Performance of the Bladder EpiCheck™ Methylation Test for Patients Under Surveillance for Non–muscle-invasive Bladder Cancer: Results of a Multicenter, Prospective, Blinded Clinical Trial
OPENALEX - Publications 
J. Alfred Witjes Juan Moróte Erik B. Cornel Georgios Gakis F. Johannes P. van Valenberg and 6 more Fernando Lozano Itay Sternberg Ellen Willemsen Miriam Lena Hegemann Yossi Paitan Ilan Leibovitch

The highly frequent strategy of surveillance for non–muscle-invasive bladder cancer (NMIBC) involves cystoscopy and cytology. Urine assays currently available have not shown performance sufficient to replace the current gold standard follow-up, which would require a very high negative predictive value (NPV), especially high-grade tumors. Bladder EpiCheck (BE) is novel urine assay that uses 15 proprietary DNA methylation biomarkers assess presence cancer. To BE NMIBC recurrence. This was...

10.1016/j.euo.2018.06.011 article EN cc-by-nc-nd European Urology Oncology 2018-07-17
 Treatment of High-grade Non–muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial “NIMBUS”
OPENALEX - Publications 
Marc‐Oliver Grimm Antoine G. van der Heijden Marc Colombel Tim Muilwijk Luis Martínez‐Piñeiro and 59 more Marko Babjuk Levent N. Türkeri Joan Palou Anup Patel Anders Bjartell Christien Caris Raymond G. Schipper Wim P.J. Witjes Jörg Horstmann S. Machtens E. Mumperow Andreas Al Ghazal Thomas Pulte Michael Stephan-Odenthal Georgios Gakis Mario W. Kramer Marc‐Oliver Grimm Dirk Zaak Bernd J. Schmitz‐Dräger Holger Schreier Jan Lehmann T. Werner Jörg Klier Jan Marin Wolfgang Rulf Eva Hellmis Andreas Schneider Spiegelhalder Manfred P. Wirth Theodor Klotz H. Suttmann M. Siebels Gerd Rodemer Robert H. Rudolph Roger Zillmann Marie L. De Bruin Sarah Bos R. van Moorselaar T. De Reijke Joost L. Boormans Bart P. Wijsman Harm H.E. van Melick E. Boven Richard P. Meijer Antoine G. van der Heijden H. Vergunst E. te Slaa Anna M. Leliveld Marc Colombel A. Ruffion Christian Pfister Morgan Rouprêt Jacques Irani Gabriel Stoica Siska Van Bruwaene Filip Ameye H.C. Arentsen Steven Joniau Pastora Beardo

10.1016/j.eururo.2020.04.066 article EN European Urology 2020-05-20
 Development of a new outcome prediction model in carcinoma invading the bladder based on preoperative serum C‐reactive protein and standard pathological risk factors: the TNR‐C score
OPENALEX - Publications 
Georgios Gakis Tilman Todenhöfer M. Renninger David Schilling Karl‐Dietrich Sievert and 2 more Christian Schwentner Arnulf Stenzl

Study Type – Prognosis (case series) Level of Evidence 4 What’s known on the subject? and What does study add? There is increasing evidence for a prognostic significance pretherapeutically elevated serum C‐reactive protein levels in various cancers. However, little about its patients with invasive bladder cancer. This shows that CRP an independent predictor cancer‐specific survival cancer, incorporation into new outcome model (TNR‐C Score) encompassing major pathological determinants...

10.1111/j.1464-410x.2011.10234.x article EN BJU International 2011-04-20
 Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial
OPENALEX - Publications 
Daniel P. Petrylak Ronald de Wit Kim N. Alexandra Drakaki Cora N. Sternberg and 95 more Hiroyuki Nishiyama Daniel Castellano Syed A. Hussain Aude Fléchon Aristotelis Bamias Evan Y. Yu Michiel S. van der Heijden Nobuaki Matsubara B. Yа. Alekseev Andrea Necchi Lajos Géczi Yen-Chuan Ou Hasan Şenol Çoşkun Wen‐Pin Su Jens Bedke Georgios Gakis Ivor Percent Jae‐Lyun Lee Marcello Tucci Andrey Semenov Fredrik Laestadius Avivit Peer Giampaolo Tortora Sufia Safina Xavier García del Muro Alejo Rodríguez‐Vida İrfan Çiçin Hakan Harputluoğlu Scott T. Tagawa Ulka N. Vaishampayan Jeanny B. Aragon‐Ching Oday Hamid Astra M. Liepa Sameera R. Wijayawardana Francesca Russo Richard A. Walgren Annamaria H. Zimmermann Rebecca R. Hozak Katherine M. Bell‐McGuinn Thomas Powles Suet-Lai Shirley Wong Thean Hsiang Tan Elizabeth Hovey Timothy Clay Siobhan Ng Annemie Rutten Jean-Pascal Machiels Herlinde Dumez Susanna Y. Cheng Cristiano Ferrario Lisa Sengeloev Niels Viggo Jensen Constance Thibault Brigitte Laguerre Florence Joly Stéphane Culine Catherine Becht Günter Niegisch Michael Stöckle Marc‐Oliver Grimm Christina A Schwentner Wolfgang Schultze‐Seemann Haralabos P. Kalofonos Dimitriοs Mavroudis Christos N. Papandreou Vasilios Karavasilis János Révész Eli Rosenbaum Raya Leibowitz‐Amit Daniel Kejzman David Sarid Giorgio V. Scagliotti Sergio Bracarda Francesco Massari Takahiro Osawa Naoto Miyajima Nobuo Shinohara Fumimasa Fukuta Chikara Οhyama Wataru Obara Shinichi Yamashita Yoshihiko Tomita Koji Kawai Satoshi Fukasawa Masafumi Oyama Junji Yonese Masayoshi Nagata Motohide Uemura Kazuo Nishimura Mutsushi Kawakita Hiroyuki Tsunemori Katsuyoshi Hashine Junichi Inokuchi Akira Yokomizo Satoshi Nagamori

10.1016/s1470-2045(19)30668-0 article EN The Lancet Oncology 2019-11-18
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