Ananya Choudhury
A5041859071- Bladder and Urothelial Cancer Treatments
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Urological Disorders and Treatments
- Effects of Radiation Exposure
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Ultrasound and Hyperthermia Applications
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
The Christie NHS Foundation Trust
2016-2025
Manchester Academic Health Science Centre
2015-2025
University of Manchester
2016-2025
Cancer Research UK Manchester Institute
2015-2025
University of California, San Francisco
2020-2025
The Christie Hospital
2015-2024
The Center for Mind-Body Medicine
2024
Stanford University
2024
NIHR Manchester Biomedical Research Centre
2018-2023
National Health Service
2010-2023
Adding abiraterone acetate with prednisolone (AAP) or docetaxel (DocP) to standard-of-care (SOC) each improved survival in systemic therapy for advanced metastatic prostate cancer: evaluation of drug efficacy: a multi-arm multi-stage platform randomised controlled protocol recruiting patients high-risk locally PCa starting long-term androgen deprivation (ADT). The provides the only direct, comparative data SOC + AAP versus DocP.
PurposeDuring a global pandemic, the benefit of routine visits and treatment patients with cancer must be weighed against risks to patients, staff, society. Prostate is one most common cancers radiation oncology departments treat, efficient resource utilization essential in setting pandemic. Herein, we aim establish recommendations framework by which evaluate prostate therapy management decisions.Methods MaterialsRadiation oncologists from United States Kingdom rapidly conducted systematic...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. POUT was a phase III, randomized, open-label trial, including 261 patients with muscle-invasive lymph...
Hypoxia is a common feature of solid tumours affecting their biology and response to therapy. One the main transcription factors activated by hypoxia hypoxia-inducible factor (HIF), which regulates expression genes involved in various aspects tumourigenesis including proliferative capacity, angiogenesis, immune evasion, metabolic reprogramming, extracellular matrix (ECM) remodelling, cell migration. This can negatively impact patient outcomes inducing therapeutic resistance. The importance...
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT postoperative after radical prostatectomy is unclear.
Abstract Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder cancer, but the choice of which treatment would be most beneficial cannot currently predicted for individual patients. The primary aim this study was to assess whether expression any a panel DNA damage signaling proteins tumor samples taken before irradiation could used as predictive marker response, or rather prognostic. Protein MRE11, RAD50, NBS1, ATM, H2AX studied by immunohistochemistry...
The aim of this prospective, phase II trial was to determine the response muscle-invasive bladder cancer (MIBC) concurrent chemoradiotherapy weekly gemcitabine with 4 weeks radiotherapy (RT; GemX).
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
BackgroundHypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate hypoxia-related mRNA signature for localized cancer.MethodHypoxia genes were identified vitro via RNA-sequencing combined vivo gene co-expression analysis generate signature. The was independently validated eleven cancer cohorts bladder phase III randomized trial of radiotherapy alone or carbogen nicotinamide (CON).ResultsA 28-gene derived. Patients high scores had poorer...
Sarcopenia is characterised by progressive and extensive skeletal muscle degeneration associated with functional decline. has primary secondary aetiology, arising as a result of the ageing process or through chronic cytokine-mediated inflammation (associated health conditions including cancer), respectively. Diagnosis sarcopenia dependent upon detection reduced strength, mass performance. A combination non-radiological radiological methods can be used to assess each these in turn accurately...
An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and address how the MR-linac could be used achieve an optimized radiation treatment approach improve patients' survival, local regional tumor control, quality life. The present paper describes organizational structure clinical part consortium. Furthermore, it elucidates why collaboration on this large project is necessary a central data registry program will implemented.
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
Abstract Purpose: Hypoxia modification improves overall survival in muscle-invasive bladder cancer patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from hypoxia modification. The study aimed to identify or derive a gene signature predicts hypoxia-modifying treatment cancer. Experimental Design: Published signatures were tested and new one derived by analyzing transcriptomic data public databases. Tumor samples available the BCON phase III randomized trial...