A5021970576- Colorectal Cancer Surgical Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Colorectal Cancer Screening and Detection
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Advances in Oncology and Radiotherapy
- Anorectal Disease Treatments and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Economic and Financial Impacts of Cancer
- Clinical practice guidelines implementation
- Radiation Dose and Imaging
University Medical Center Utrecht
2016-2025
St. Antonius Ziekenhuis
2015-2024
Utrecht University
2011-2024
Heidelberg University
2013-2024
University Hospital Heidelberg
2013-2024
Amsterdam University Medical Centers
2024
University of Amsterdam
2024
Cancer Center Amsterdam
2024
Netherlands Comprehensive Cancer Organisation
2022-2023
Cancer Genomics Centre
2018-2022
To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic-CT (sCT) images need to be generated. Considering the application MR-guided online adaptive replanning, sCT generation should occur within minutes. This work aims at assessing whether an existing deep learning network can rapidly generate used for accurate MR-based dose calculations entire pelvis. A study was conducted on data 91 patients with prostate, rectal cervical...
Importance A watch-and-wait approach for patients with rectal cancer and a clinical complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated better quality of life functional outcome. Nevertheless, prospective data on both parameters are scarce. Objective To prospectively evaluate outcome, including bowel, urinary, sexual function, following approach. Design, Setting, Participants total 278 near-complete were included in 2 cohort studies: single-center study (March...
Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5 × 7 Gy) of pelvic lymph node oligometastases. The workflow allows full online planning based on daily anatomy. Session duration less than 60 min. Quality assurance tests, including independent 3D dose calculations and film measurements were passed.
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
Background and purposeDaily online adaptation of the clinical target volume (CTV) using MR-guided radiotherapy enables margin reduction planning (PTV). This study describes implementation initial experience on 1.5T MR-linac evaluates treatment time, patient compliance, coverage, including an assessment reduction.Materials methodsPatients were treated a (7MV, FFF). At each fraction 3D T2 weighted (T2w) MR-sequence was acquired which CTV adapted after deformable registration contours from...
Aim of this study was to develop a generalised radiomics model for predicting pathological complete response after neoadjuvant chemo-radiotherapy in locally advanced rectal cancer patients using pre-CRT T2-weighted images acquired at 1.5 T and 3 scanner.In two institutions, 195 were scanned: 136 scanned on MR scanner, 59 scanner. Gross tumour volumes delineated the 496 radiomic features extracted, applying intensity-based (IB) filter. Features standardised with Z-score normalisation an...
Abstract Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy achieving organ preservation longer‐term oncological outcomes are unknown; thus there is a need high trials. Method Can we S ave the rectum by watchful waiting or T rans A nal surgery following (chemo) R adiotherapy versus otal early RE ctal C ancer (STAR‐TREC) an international...
This work reports on the first seven patients treated with gating and baseline drift correction high-field MR-Linac system. Dosimetric analysis showed that active motion management system improved congruence to planned dose, efficiently mitigating detrimental effects of intrafraction in upper abdomen.
Background Patient selection for organ sparing treatment after good response to neo‐adjuvant chemoradiation (CRT) locally advanced rectal cancer is challenging as no optimal restaging modality available CRT. In this study, we assessed the value of dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) pathological prediction. Methods 51 patients with cancer, tumor volume and transfer constant (Ktrans) were obtained at 3 Tesla before CRT surgery. The predictive potential complete...
IntroductionRectal cancer surgery with neoadjuvant therapy is associated substantial morbidity. The present study describes the course of quality life (QOL) in rectal patients first 2 years after start treatment.Patients and MethodsWe performed a prospective within colorectal cohort including who were referred for chemoradiation or short-course radiotherapy underwent surgery. QOL was assessed using European Organization Research Treatment Cancer core questionnaire (EORTC QLQ-C30) QLQ-CR29)...
PurposePathologic complete tumor response after chemoradiation in patients with locally advanced rectal cancer (LARC) is associated a favorable prognosis and allows organ-sparing treatment strategies. In the RECTAL-BOOST trial, we aimed to investigate effect of an external radiation boost before on pathologic or sustained clinical LARC.Methods MaterialsThis multicenter, nonblinded, phase 2 randomized controlled trial followed trials-within-cohorts design, which pragmatic design allowing...
Treatment for locally advanced rectal cancer (LARC) consists of chemoradiation therapy (CRT) and surgery. Approximately 15% patients show a pathological complete response (pCR). Increased pCR-rates can be achieved through dose escalation, thereby increasing the number eligible organ-preservation to improve quality life (QoL). A randomized comparison 65 versus 50Gy with external-beam radiation alone has not yet been performed. This trial investigates pCR rate, clinical response, toxicity, QoL...
Patients were treated at our institute for single and multiple lymph node oligometastases on the 1.5T MR-linac since August 2018. The superior soft-tissue contrast additional software features of compared to CBCT-linacs allow online adaptive treatment planning. purpose this study was perform a target coverage dose criteria based evaluation clinically delivered radiotherapy with conventional CBCT-linac treatment.Patient data used from 14 patients 6 (2-3) metastases. All prescribed 5 × 7 Gy...
To enable magnetic resonance imaging (MRI)-guided radiotherapy with real-time adaptation, motion must be quickly estimated low latency. The estimate is used to adapt the radiation beam current anatomy, yielding a more conformal dose distribution. As MR acquisition largest component of latency, deep learning (DL) may reduce total latency by enabling much higher undersampling factors compared conventional reconstruction and estimation methods. benefit DL on image was investigated for obtaining...
Abstract Background Novel definitions suggest that resectability status for pancreatic ductal adenocarcinoma (PDAC) should be assessed beyond anatomical criteria, considering both biological and conditional factors. This has, however, yet to validated on a nationwide scale. study evaluated the prognostic value of factors staging patients with resectable PDAC. Patients Methods A observational cohort was performed, including all consecutive who underwent upfront resection National...
Abstract Background Disease recurrence remains one of the biggest concerns in patients after resection pancreatic ductal adenocarcinoma (PDAC). Despite (neo)adjuvant systemic therapy, most experience local and/or distant PDAC within 2 years. High-level evidence regarding benefits recurrence-focused surveillance is missing, and impact early detection treatment on survival quality life unknown. In European countries, follow-up surgery for currently lacking. Consequently, guidelines...