A5065993006- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- MRI in cancer diagnosis
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Advanced MRI Techniques and Applications
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Head and Neck Cancer Studies
- Bioinformatics and Genomic Networks
- Lung Cancer Research Studies
University Medical Center Utrecht
2016-2025
Utrecht University
2018-2024
Heidelberg University
2019-2023
University Hospital Heidelberg
2019-2023
Radiation Oncology Associates
2017-2022
Cardiff University
2016
The Netherlands Cancer Institute
2006-2015
Oncode Institute
2007-2013
The University of Texas Health Science Center at San Antonio
2011
Netherlands Comprehensive Cancer Organisation
2009-2011
The standard curative treatment for patients with esophageal cancer is perioperative chemotherapy or preoperative chemoradiotherapy followed by open transthoracic esophagectomy (OTE). Robot-assisted minimally invasive thoracolaparoscopic (RAMIE) may reduce complications.A single-center randomized controlled trial was conducted, assigning 112 resectable intrathoracic to either RAMIE OTE. primary endpoint the occurrence of overall surgery-related postoperative complications (modified...
The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation currently ongoing through MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, 6,000-patient randomized, multicentric trial. This article reviews several steps development of from its discovery clinical validation.
The CROSS trial established neoadjuvant chemoradiotherapy (nCRT) for patients with resectable esophageal adenocarcinoma (rEAC). In the PERFECT trial, we investigated feasibility and efficacy of nCRT combined programmed-death ligand-1 (PD-L1) inhibition rEAC.Patients rEAC received according to regimen five cycles atezolizumab (1,200 mg). primary endpoint was administering in ≥75% patients. A propensity score-matched cohort used compare pathologic response, overall survival, progression-free...
Online adaptive magnetic resonance-guided radiotherapy (MRgRT) enables high-precision for esophageal cancer patients but is less feasible due to long on-table times in combination with long-course treatment. In this study, we conducted an in-silico assessment of a simplified online workflow, Adapt-To-Shape-lite (ATS-lite), which deformable propagated contours are not modified, and assessed its feasibility. The ATS-lite workflow was simulated all fractions nine who had previously received...
BackgroundMammographic screening has led to a proportional shift toward earlier-stage breast cancers at presentation. We assessed whether the method of detection provides prognostic information above and beyond standard factors investigated accuracy predicted overall cancer–specific survival by computer tool Adjuvant! among patients with screen-detected, interval, nonscreening-related carcinomas.
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
The pace of innovation in radiation oncology is high and the window opportunity for evaluation narrow. Financial incentives, industry pressure, patients' demand high-tech treatments have led to widespread implementation innovations before, or even without, robust evidence improved outcomes has been generated. standard phase I-IV framework drug not most efficient desirable assessment technological innovations. In order provide a methodology clinical radiotherapy, we adapted surgical IDEAL fit...
Background and purposeDaily online adaptation of the clinical target volume (CTV) using MR-guided radiotherapy enables margin reduction planning (PTV). This study describes implementation initial experience on 1.5T MR-linac evaluates treatment time, patient compliance, coverage, including an assessment reduction.Materials methodsPatients were treated a (7MV, FFF). At each fraction 3D T2 weighted (T2w) MR-sequence was acquired which CTV adapted after deformable registration contours from...
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
Several gene expression signatures have been proposed and demonstrated to be predictive of outcome in breast cancer. In the present article we address following issues: Do these perform similarly? Are there (common) molecular processes reported by signatures? Can better prognostic predictors constructed based on identified processes? We performed a comprehensive analysis performance nine seven different cancer datasets. To characterize functional associated with signatures, enlarged each...
6 Background: The standard curative treatment for patients with esophageal cancer is perioperative chemotherapy or preoperative chemoradiotherapy followed by open transthoracic esophagectomy (OTE). Robot-assisted minimally invasive thoraco-laparoscopic (RAMIE) may reduce complications and improve functional recovery. Methods: In this randomized controlled trial, 112 resectable intrathoracic were randomly assigned to RAMIE OTE. composite primary endpoint was the occurrence of overall...