Grard A. P. Nieuwenhuijzen
A5037535575- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Breast Lesions and Carcinomas
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Global Cancer Incidence and Screening
- Gastrointestinal Tumor Research and Treatment
- Breast Implant and Reconstruction
- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Clinical practice guidelines implementation
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- HER2/EGFR in Cancer Research
Catharina Ziekenhuis
2016-2025
Radboud University Nijmegen
2016-2025
Southampton General Hospital
2023
University of Southampton
2023
St. Antonius Ziekenhuis
2023
PAMM
2021
Maastricht University
2007-2021
Maastricht University Medical Centre
2012-2021
Leiden University Medical Center
2012-2021
St. Vincent's University Hospital
2019
The role of neoadjuvant chemoradiotherapy in the treatment patients with esophageal or esophagogastric-junction cancer is not well established. We compared followed by surgery alone this patient population.
Objective This study investigates the course of serum cytokine levels in patients with multiple trauma, a ruptured abdominal aortic aneurysm (AAA), and undergoing elective AAA repair relationship these cytokines to development adult respiratory distress syndrome (ARDS) organ failure (MOF). Summary Background Data Severe tissue hemorrhagic shock, ischemia-reperfusion injury are pathophysiologic mechanisms that may result an excessive uncontrolled activation inflammatory cells mediators....
PURPOSE Preoperative chemoradiotherapy according to the for esophageal cancer followed by surgery study (CROSS) has become a standard of care patients with locally advanced resectable or junctional cancer. We aimed assess long-term outcome this regimen. METHODS From 2004 through 2008, we randomly assigned 366 either five weekly cycles carboplatin and paclitaxel concurrent radiotherapy (41.4 Gy in 23 fractions, 5 days per week) surgery, alone. Follow-up data were collected 2018. Cox...
To investigate the morbidity that is associated with learning curve of minimally invasive esophagectomy.Although curves have been described, it currently unknown how much extra technically challenging surgical procedures.Prospectively collected data were retrospectively analyzed all consecutive patients undergoing Ivor Lewis esophagectomy in 4 European expert centers. The primary outcome parameter was anastomotic leakage. Secondary parameters operative time and textbook ("optimal outcome")....
To assess whether laparoscopic cholecystectomy is superior to percutaneous catheter drainage in high risk patients with acute calculous cholecystitis.Multicentre, randomised controlled, superiority trial.11 hospitals the Netherlands, February 2011 January 2016.142 cholecystitis were randomly allocated (n=66) or (n=68). High was defined as an physiological assessment and chronic health evaluation II (APACHE II) score of 7 more.The primary endpoints death within one year occurrence major...
Objective: To define "best possible" outcomes in total minimally invasive transthoracic esophagectomy (ttMIE). Background: TtMIE, performed by experts patients with low comorbidity, may serve as a benchmark procedure for esophagectomy. Patients and Methods: From cohort of 1057 ttMIE, over 5-year period 13 high-volume centers esophageal surgery, we selected study group 334 (31.6%) that fulfilled criteria comorbidity (American Society Anesthesiologists score ≤2, WHO/ECOG ≤1, age ≤65 years,...
Abstract Background Quality assurance is acknowledged as a crucial factor in the assessment of oncological surgical care. The aim this study was to develop composite measure multiple outcome parameters defined ‘textbook outcome’, assess quality care for patients undergoing oesophagogastric cancer surgery. Methods Patients with cancer, operated on intent curative resection between 2011 and 2014, were identified from national database (Dutch Upper Gastrointestinal Cancer Audit). Textbook...
The Stent-In 2 trial randomized patients with malignant colonic obstruction to emergency surgery or stent placement as a bridge elective surgery. aim of this study was compare the oncological outcomes.Disease recurrence, and disease-free, disease-specific overall survival were evaluated, including subgroup analysis stent- guidewire-related perforation.Of 98 included in original trial, benign (16) incurable (23) disease excluded from study, along patient who had withdrawn trial. Of remaining...
The European Organisation for Research and Treatment of Cancer 10981-22023 AMAROS trial evaluated axillary lymph node dissection (ALND) versus radiotherapy (ART) in patients with cT1-2, node-negative breast cancer a positive sentinel (SN) biopsy. At 5 years, both modalities showed excellent comparable control, significantly less morbidity after ART. We now report the preplanned 10-year analysis recurrence rate (ARR), overall survival (OS), disease-free (DFS), an updated 5-year quality...
Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have pathologically complete response in the resection specimen. This provides rationale investigating an active surveillance approach. The aim study to assess (cost-)effectiveness vs. oesophagectomy after nCRT
Abstract Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, the majority of data from single-centre series. This study analysed an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized on patients who had pelvic LRRC between 2004 and 2014 were accrued 27 specialist centres. The primary endpoint was survival. impact resection margin, bone resection, node status use...
The oncological efficacy and safety of laparoscopic gastrectomy are under debate for the Western population with predominantly advanced gastric cancer undergoing multimodality treatment.In 10 experienced upper GI centers in Netherlands, patients resectable (cT1-4aN0-3bM0) adenocarcinoma were randomly assigned to either or open gastrectomy. No masking was performed. primary outcome hospital stay. Analyses performed by intention treat. It hypothesized that leads shorter stay, less...
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
The current trend in postoperative nutrition is to promote a normal oral diet as early possible. However, ileus frequent and common problem after major abdominal surgery. This study was designed investigate whether enteral (EEN), bridge diet, can reduce ileus.Patients undergoing rectal surgery for locally advanced primary or recurrent carcinoma (after neoadjuvant (chemo)-radiation, with without intraoperative radiotherapy) were randomly assigned EEN (n = 61) parenteral (EPN, n 62) addition...
The optimal treatment for locally recurrent rectal cancer (LRRC) is still a matter of debate. This study assessed the outcome LRRC patients treated with multimodality treatment, consisting neoadjuvant radio (chemo-) therapy, extended resection, and intraoperative radiotherapy.One hundred forty-seven consecutive who underwent between 1994 2006 were studied. prognostic values patient-, tumor- treatment-related characteristics tested uni- multivariate analysis.Median overall survival was 28...
Abstract Purpose: After preoperative (radio)chemotherapy, histologic determinants for prognostification have changed. It is unclear which variables, including assessment of tumor regression, are the best indicators local recurrence and survival. Experimental Design: A series 201 patients with locally advanced rectal cancer (cT3/T4, M0) presenting an involved or at least threatened circumferential margin (CRM) on imaging (<2 mm) were evaluated using standard histopathologic variables...