A5075160005- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Sphingolipid Metabolism and Signaling
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Enhanced Recovery After Surgery
- Protein Kinase Regulation and GTPase Signaling
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Cancer, Lipids, and Metabolism
- Diverticular Disease and Complications
- Metastasis and carcinoma case studies
- Diagnosis and treatment of tuberculosis
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Appendicitis Diagnosis and Management
The University of Tokyo
2004-2025
Tokyo National Hospital
2014-2023
Southampton General Hospital
2023
University of Southampton
2023
University of Tokyo Hospital
2021-2023
National Cancer Center Hospital East
2013-2022
Kurume University
2021
Tokyo University of Science
2021
National Cancer Center
2017-2020
Tokyo Medical University Hospital
2020
Abstract Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, the majority of data from single-centre series. This study analysed an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized on patients who had pelvic LRRC between 2004 and 2014 were accrued 27 specialist centres. The primary endpoint was survival. impact resection margin, bone resection, node status use...
It remains controversial whether primary tumor resection (PTR) before chemotherapy improves survival in patients with colorectal cancer (CRC) asymptomatic and synchronous unresectable metastases.This randomized phase III study investigated the superiority of PTR followed by versus alone relation to overall (OS) stage IV CRC three or fewer metastatic diseases confined liver, lungs, distant lymph nodes, peritoneum. Chemotherapy regimens either mFOLFOX6 plus bevacizumab CapeOX were decided...
Autotaxin (ATX) is a multifunctional phosphodiesterase originally isolated from melanoma cells as potent cell motility-stimulating factor. ATX identical to lysophospholipase D, which produces bioactive phospholipid, lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC). Although enhanced expression of in various tumor tissues has been repeatedly demonstrated, and thus, implicated progression tumor, the precise role expressed by was unclear. In this study, we found that highly...
Abstract Sphingosine-1-phosphate is a potent lipid mediator formed by phosphorylation of sphingosine, metabolite sphingolipids, catalyzed two sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2. Expression SphK2, which enriched in the nucleus MCF7 human breast cancer cells, increased expression cyclin-dependent inhibitor p21 but had no effect on p53 or its phosphorylation. The anticancer drug doxorubicin known to increase via p53-dependent p53-independent mechanisms. Down-regulation...
Abstract Background Japan Clinical Oncology Group (JCOG) 0212 (ClinicalTrials.gov NCT00190541) was a non-inferiority phase III trial of patients with clinical stage II–III rectal cancer without lateral pelvic lymph node enlargement. The compared mesorectal excision (ME) ME and dissection (LLND), primary endpoint recurrence-free survival (RFS). planned analysis at 5 years failed to confirm the alone LLND. present study aimed compare LLND using long-term follow-up data from JCOG0212. Methods...
Adjuvant chemotherapy after hepatectomy is controversial in liver-only metastatic colorectal cancer (CRC). We conducted a randomized controlled trial to examine if adjuvant modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) superior alone for metastasis from CRC.In this phase II or III (JCOG0603), patients age 20-75 years with confirmed CRC an unlimited number of liver lesions were randomly assigned 12 courses mFOLFOX6 hepatectomy. The primary end point was disease-free...
Abstract Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes important for cancer progression. S1P is produced by two sphingosine kinases, SphK1 SphK2. Expression elevated in many cancers. Here, we report that LPA markedly enhanced mRNA protein gastric MKN1 cells but had no effect on also up-regulated expression other human endogenously express the LPA1 receptor, such as DLD1 colon MDA-MB-231 breast cells, not HT29 or...
Enhanced recovery after surgery (ERAS) protocols are now well-known to be useful for elective colorectal surgery, as they result in shorter hospital stays without adversely affecting morbidity. However, the efficacy and safety of ERAS patients with obstructive cancer have yet clarified.We evaluated 122 consecutive resections performed between July 2008 November 2012 at Tokyo Metropolitan Bokutoh Hospital. Patients rupture or impending those who received simple colostomy were excluded. The...
Abstract Background Assessment of preoperative general condition to predict postoperative outcomes is important, particularly in older patients who typically suffer from various comorbidities and exhibit impaired functional status. In addition indices such as Charlson Comorbidity Index (CCI), National Institute on Aging Cancer (NIA/NCI), Adult Evaluation-27 (ACE-27), American Society Anesthesiologists Physical Status classification (ASA-PS), controlling nutritional status (CONUT) score...
Abstract Background Recent evidence suggests that both preoperative and postoperative inflammation-based prognostic markers are useful for predicting the survival of colorectal cancer (CRC) patients. However, associations between longitudinal changes in prognosis controversial. Methods The subjects this study were 568 patients with stage III CRC 2008 2014. Preoperative neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), C-reactive protein/albumin (CAR)...
Abstract Introduction Lysophosphatidic acid (LPA) is a bioactive phospholipid with diverse effects on various cells. It interacts at least three G-protein-coupled transmembrane receptors, namely LPA1, LPA2 and LPA3, whose expression in tumours has not been fully characterized. In the present study we characterized profile of LPA receptors human breast cancer tissue assessed possible roles each receptor. Methods The relative levels receptor's mRNA against β-actin was examined surgically...
Enhanced recovery after surgery (ERAS) protocols may reduce postoperative complications and the length of hospital stay. Studies effectiveness ERAS should include not only doctor-reported outcomes, but also patient-reported in order to better estimate their impact on recovery. However, outcomes are commonly reported. Thus, it needs be assessed whether early discharge from is compatible with a outcome viewpoint patients themselves.The 40-item quality score (QoR-40) recovery-specific,...
It is controversial whether chemotherapy with or without primary tumour resection effective for the patients incurable Stage IV colorectal cancer. A randomized controlled trial, initiated in Japan 2012, being conducted to evaluate survival benefit and safety of plus compared alone asymptomatic cancer unresectable metastatic disease. Patients are randomly assigned either followed by chemotherapy. The endpoint overall survival. Secondary endpoints progression-free survival, incidence adverse...
<b><i>Introduction:</i></b> The clinical benefit of extended lymphadenectomy for synchronous extraregional lymph node metastasis, such as para-aortic (PALN) metastasis in colorectal cancer, remains highly controversial. <b><i>Aim:</i></b> To evaluate the PALN dissection cancer patients with or without multiorgan metastases. <b><i>Methods:</i></b> Thirty-six pathologically positive below renal veins who underwent...
Abstract Aim We investigated the clinical impact of D3 lymph node dissection preserving left colic artery (LCA) compared to without LCA preservation using data from JCOG0404. is expected maintain adequate blood supply, which effective in preventing anastomotic leakage, intestinal paralysis, and bowel obstruction. Whether with (Group A) improves outcomes following resection sigmoid colon cancer B) unclear. Methods Procedure type was identified photographs surgical field collected for central...