A5003461246- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pelvic floor disorders treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Hernia repair and management
- Diverticular Disease and Complications
- Enhanced Recovery After Surgery
- COVID-19 and healthcare impacts
- Surgical site infection prevention
- Diagnosis and treatment of tuberculosis
- Body Contouring and Surgery
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Amoebic Infections and Treatments
- Bariatric Surgery and Outcomes
- Biomedical Ethics and Regulation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Body Image and Dysmorphia Studies
- Sarcoma Diagnosis and Treatment
University Hospital Southampton NHS Foundation Trust
2024
South University
2024
University of Southampton
2023
University of Buraimi
2023
Southampton General Hospital
2023
Imperial College London
2015-2020
Royal Marsden Hospital
2013-2020
Chelsea and Westminster Hospital
2017-2020
Royal Adelaide Hospital
2019
Emory and Henry College
2019
Abstract Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, the majority of data from single-centre series. This study analysed an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized on patients who had pelvic LRRC between 2004 and 2014 were accrued 27 specialist centres. The primary endpoint was survival. impact resection margin, bone resection, node status use...
Abstract Objective The present study investigated the risk of lymph node metastasis according to depth tumour invasion in patients undergoing resection for rectal cancer. Method histology oncological with regional lymphadenectomy cancer at St Marks Hospital from 1971 1996 was reviewed. Of total number 1549 patients, 303 T 1 or 2 cancers were selected. type, grade, evidence vascular invasion, submucosal (classed into ‘sm1‐3’) evaluated as potential predictors positivity using univariate and...
The hypoxia-mediated response of tumours is a major determining factor in growth and metastasis. Understanding tumour biology under hypoxic conditions crucial for the development antiangiogenic therapy. Using one largest cohorts rectal adenocarcinomas to date, this study investigated hypoxia-inducible factor-1alpha (HIF-1alpha) HIF-2alpha protein expression relation cancer recurrence cancer-specific survival. Patients (n=90) who had undergone surgery adenocarcinoma, with no prior neoadjuvant...
ABSTRACT Introduction The face is an important part of the body for identification, communicative and adornment roles. Due to its prominence, Injuries scars on have psychological impact individuals living with them. Besides placement incisions at junction facial aesthetic units, orientation surgical along skin creases, paying attention principles during wound closure prevent unacceptable scars, technique used wounds also influences cosmetic outcome their scars. There paucity studies outcomes...
Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility organ preservation.MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 muscularis) versus >T2 tumours was compared gold standard pT stage T1sm1/2 ≤pT2 >pT2. N also compared. The MRI protocol employed a surface phased array coil high resolution (0.6×0.6×3 mm resolution). staging data were analysed from...
The multidisciplinary perioperative and anaesthetic management of patients undergoing pelvic exenteration is essential for good surgical outcomes. No clear guidelines have been established, there wide variation in clinical practice internationally. This consensus statement consolidates experience best collectively, systematically addresses key domains the management.The modified Delphi methodology was used to achieve from PelvEx Collaborative. process included one round online questionnaire...
There is wide disparity in the care of patients with multivisceral involvement rectal cancer. The results are presented treatment advanced and recurrent colorectal cancer from a centre where dedicated multidisciplinary team (MDT) central to management.All consecutive MDT referrals between 2010 2014 were examined. Analysis was undertaken referral pathway, site, selection process, management decision, R0 resection rate, mortality/morbidity/Clavien-Dindo (CD) classification morbidity, length...
significant impact on the delivery of colorectal cancer (CRC) care, among other surgical services, due to need
A tension-free well vascularized colorectal or coloanal anastomosis is not always possible following rectal sigmoid resection. The study reports on the short-term and long-term outcome of a modified right colon inversion technique as means facilitating low anastomosis.All patients who underwent colonic inversion, Deloyers' procedure, were identified retrospectively from prospective database Colorectal Department Royal Marsden Hospital October 2008 to December 2013.There 14 (nine male) median...
Abstract Aim The influence of the height rectal cancer from anal verge on oncological outcome is controversial. This study aimed to determine tumour survival patients treated in a specialized unit. Method Patients undergoing surgery for primary 2006 2013 were identified prospectively maintained database. Those requiring total or multicompartmental pelvic exenteration excluded. Low was defined as < 5 cm verge, assessed by endoscopy and/or digital examination. 3‐year disease‐free ( DFS )....
This study compared the operative outcome and long-term survival of three types hand-sewn coloanal anastomosis (CAA) for low rectal cancer.Patients presenting with cancer at a single centre between 2006 2014 were classified into CAA: type 1 (supra-anal tumours undergoing transabdominal division rectum transanal mucosectomy); 2 (juxta-anal tumours, partial intersphincteric resection); 3 (intra-anal near-total resection mesorectal excision).Seventy-one patients underwent 17 1; 39 2; 15 3. The...