A5110859420- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Geophysical Methods and Applications
- Geophysical and Geoelectrical Methods
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Seismic Imaging and Inversion Techniques
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Seismic Waves and Analysis
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- Medical Imaging Techniques and Applications
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cardiac tumors and thrombi
- Inflammatory Bowel Disease
- Dementia and Cognitive Impairment Research
- Angiogenesis and VEGF in Cancer
Heidelberg University
2024
University Hospital Heidelberg
2024
University of Münster
2023
München Klinik
2005-2021
Leibniz Institute of Virology (LIV)
2014-2020
St Mark's Hospital
2006-2017
Leibniz Institute for Applied Geophysics
2017
St. Mark's Hospital
2010-2017
Hamburg Institut (Germany)
2017
University of Kassel
2016
Background: Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal capillaries and improves contrast This study examined whether second pass with NBI in the proximal colon helped detect additional adenomas patients HNPCC. Methods: 62 from HNPCC families (Amsterdam II...
OBJECTIVES: In ulcerative colitis surveillance, chromoendoscopy improves dysplasia detection 3–5-fold compared with white light endoscopy (WLE). The aim of this study was to investigate whether narrow band imaging (NBI) can improve WLE. METHODS: This a randomized, parallel-group trial. A total 220 patients were needed be recruited detect threefold increase in detection. all, 112 long-standing randomized colonoscopic extubation NBI (56) or WLE (1:1 ratio) at two tertiary units the United...
In ulcerative colitis (UC) gut bacteria drive inflammation. Bacterial recognition and T-cell responses are shaped by intestinal dendritic cells (DCs); therapeutic effects of probiotic may relate to modulation DC. The mixture, VSL#3, increases interleukin (IL)-10 downregulates IL-12p40 production DC in vitro. We evaluated vivo oral VSL#3 steroids on colonic patients with acute UC.Rectal biopsies were obtained from active UC before after treatment corticosteroids, or placebo, healthy controls....
Purpose: To establish the relationships between quantitative perfusion computed tomography (CT) parameters—specifically, primary tumor blood flow, volume, transit time, and permeability surface-area product—and immunohistologic markers of angiogenesis in colorectal cancer. Materials Methods: After institutional review board approval informed patient consent were obtained for this prospective study, 23 patients (11 men, 12 women; mean age, 68.4 years; age range, 34.8–87.1 years) with...
See also: Commentaire de travail J. E. East et al., pp. 811Endoscopy 2008; 40(10): 970-971DOI: 10.1055/s-0032-1306880
BackgroundHere, we describe a multifactorial investigation of the events SARS-CoV-2 outbreak in largest meat processing complex Germany. MethodsTiming infection events, spatial relationship between workers plant, climate and ventilation conditions, sharing living quarters transport, full viral genome sequences recovered from PCR-confirmed cases were analyzed.FindingsTransmissions occurred confined area plant which air is constantly re-circulated cooled to 10°C. Index case B1 transmitted...
Summary Background Colonoscopy has a known miss rate for polyps and adenomas. High definition (HD) colonoscopes may allow detection of subtle mucosal change, potentially aiding adenomas hyperplastic polyps. Aim To compare rates between HD standard (SD) colonoscopy. Methods Prospective, cohort study with optimized withdrawal technique (withdrawal time >6 min, antispasmodic, position changes, re‐examining flexures folds). One hundred thirty patients attending routine colonoscopy were...
Abstract Objective The present study investigated the risk of lymph node metastasis according to depth tumour invasion in patients undergoing resection for rectal cancer. Method histology oncological with regional lymphadenectomy cancer at St Marks Hospital from 1971 1996 was reviewed. Of total number 1549 patients, 303 T 1 or 2 cancers were selected. type, grade, evidence vascular invasion, submucosal (classed into ‘sm1‐3’) evaluated as potential predictors positivity using univariate and...
Hyperplastic Polyposis (HPPS) is a poorly characterized syndrome that increases colorectal cancer (CRC) risk. We aimed to provide molecular classification of HPPS. obtained 282 tumours from 32 putative HPPS patients with >or= 10 hyperplastic polyps (HPs); some also had adenomas and CRCs. found no good evidence microsatellite instability (MSI) in our samples. The epithelium HPs was monoclonal. Somatic BRAF mutations occurred two-thirds patients' HPs, KRAS2 10%; both were more common younger...
The hypoxia-mediated response of tumours is a major determining factor in growth and metastasis. Understanding tumour biology under hypoxic conditions crucial for the development antiangiogenic therapy. Using one largest cohorts rectal adenocarcinomas to date, this study investigated hypoxia-inducible factor-1alpha (HIF-1alpha) HIF-2alpha protein expression relation cancer recurrence cancer-specific survival. Patients (n=90) who had undergone surgery adenocarcinoma, with no prior neoadjuvant...
HAdV express early viral genes to modulate the activity of cellular tumor suppressor p53 and ensure efficient replication, through various processes, whilst some them are not completely understood. oncoprotein E1B-55K interactions with SUMO, PML-IV/V Sp100A tightly connected transforming potential factor in non-lytic infections. SUMO modified DNA binding protein (DBP) E2A interacts PML acting as a molecular bridge between replication centers (RCs) tracks. Here, we show for first time, that...
The DNA double-stranded genome of human adenoviruses (HAdV) is preferentially targeted by host factors involved in chromatin remodeling, such as SPOC1 and KAP1 to inhibit efficient viral gene expression. HAdV genomes undergo alterations through association with histones epigenetic modifications; however, the precise underlying mechanism remains elusive. A recently discovered silencing for retrotransposons retroviruses involves Human Silencing Hub (HUSH) complex. This complex MPP8, TASOR,...
Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of a number human neoplasms. KSHV causes lifelong chronic infections by establishing persistent reservoirs latently infected cells in which viral double-stranded DNA genome present form an extrachromosomal episome. Polycomb group protein (PcG) mediated gene repression detected early after entry CpG-rich and epigenetically naive into host nucleus. Here we show that establishment maintenance latency strongly influenced...
To reproduce focusing in virtual microscopy, it is necessary to construct 3-dimensional (3D) slides composed of whole slide images with different focuses. As frequently used for the assessment Helicobacter pylori colonization diagnostic pathology, we prepared 3D up 9 focus planes from 144 gastric biopsy specimens or without H gastritis. The were diagnosed a blinded manner by 3 pathologists according updated Sydney classification using conventional microscopy single plane, and 5 enabling...
In vivo optical diagnosis of small colorectal polyps has potential clinical and cost advantages, but requires accuracy high interobserver agreement for clinically acceptability. We aimed to assess variability diagnostic performance endoscopic imaging modalities in characterizing colonic polyps.High quality still images 80 < 1 cm were recorded using white-light endoscopy (WLE), autofluorescence (AFI) narrow-band with without magnification (NBI NBImag). All assessed quality, prediction polyp...
Invariant natural killer T (iNKT)/natural (NK)/cytokine-induced (CIK) cells are important for immune surveillance. (I) Novel combinations of antibody 6B11 (targeting the Vα24-Jα18-invariant T-cell receptor) with CD4/CD8/CD1d/Vα24 iNKT subset detection and "T/NK cell-like"-iNKT subsets were defined. Compared healthy peripheral blood mononuclear (MNC) (significantly) lower proportions (6B11/6B11CD3/6B11CD161), NK (CD3CD56/CD3CD161), CIK (CD3CD56/CD3CD161) found in MNC from acute myeloid...
Abstract Aim The study aimed to investigate whether narrow‐band imaging (NBI) can enhance adenoma detection in patients at high risk for adenomas compared with high‐definition white‐light endoscopy (WLE). High was defined as three or more last colonoscopy, history of colorectal cancer and positive faecal occult blood test. Method Two hundred fourteen were randomized 1:1 examination NBI WLE. primary outcome measure the proportion least one detected. Secondary outcomes included total polyps,...
Abstract Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli ( APC ), has a major role in colorectal cancer (CRC). Most components have not been assessed for sporadic CRC. We analyzed AXIN2 , CK1 α, DKK1 GSK‐3 β, SOX17, LRP6 and PPP2R1B β‐ catenin collection CRCs n = 47) CRC cell lines (CLs; 26). The set was enriched microsatellite unstable cancers (MSI+, 30%, 14/47). Somatic found or β; but heterozygous frame‐shift mutations, an in‐frame...
Recurrence of Crohn's disease (CD) after ileal or colonic resection is common. Myenteric plexitis in the proximal margin an ileocolonic CD specimen may indicate ongoing pathology that relates to recurrence. We assessed risk factors for myenteric plexitis, effect on clinical recurrence, and whether preoperative medical therapies affect intensity plexitis.Ileocolonic specimens from 99 patients with were histologically scored presence severity plexitis. was correlated immunosuppressive therapy...