A5051088474- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Laser-Plasma Interactions and Diagnostics
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Laser-induced spectroscopy and plasma
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Receptor Mechanisms and Effects
- Functional Brain Connectivity Studies
- Laser-Matter Interactions and Applications
- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Bone health and osteoporosis research
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- High-pressure geophysics and materials
- Bariatric Surgery and Outcomes
- Neurological disorders and treatments
Friedrich Schiller University Jena
2015-2024
Leipzig University
2013-2023
Max Planck Institute of Quantum Optics
2016-2022
University Hospital Leipzig
2005-2022
Klinik und Poliklinik für Nuklearmedizin
1999-2018
IFB Adiposity Diseases
2014
University of Tübingen
1971-2002
Max Planck Society
1997-2002
Max Planck Institute for Evolutionary Biology
1997-2002
Technical University of Munich
2001
There is presently no specific information available concerning the nature and course of cognitive deficits caused by intracranial meningiomas. In this prospective study authors examined functioning patients with frontal meningiomas.Fifty-four meningiomas were neuropsychologically before after neurosurgery. The test battery consisted standardized instruments including those assessing memory, attention, visuoconstructive abilities, executive functions. time period between pre-and...
<h3>Context</h3> Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through α4β2*–nicotinic acetylcholine receptors (α4β2*-nAChRs). <h3>Objective</h3> To assess the availability of α4β2*-nAChRs their relationship mild cognitive symptoms vivo PD. <h3>Design</h3> Crossover comparison between PD healthy volunteers (control group) using α4β2*-nAChR–specific radioligand...
(18)F-florbetaben is a novel (18)F-labeled tracer for PET imaging of β-amyloid deposits in the human brain. We evaluated kinetic model-based approaches to quantification binding brain from dynamic data. The validity practically useful tissue ratio was also against parameters.(18)F-florbetaben performed with concurrent multiple arterial sampling after injection (300 MBq) 10 Alzheimer disease (AD) patients and age-matched healthy controls. Regional brain-tissue time-activity curves 90 min were...
Introduction We aimed at dissociating the neural correlates of memory disorders in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Methods included patients with AD (n = 19, 11 female, mean age 61 years) FTLD 11, 5 early stages their diseases. Memory performance was assessed by means verbal visual subtests from Wechsler Scale (WMS-R), including forgetting rates. Brain glucose utilization measured [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) brain...
Abstract Purpose Pridopidine is an investigational drug for Huntington disease (HD). was originally thought to act as a dopamine stabilizer. However, pridopidine shows highest affinity the sigma-1 receptor (S1R) and enhances neuroprotection via S1R in preclinical studies. Using [ 18 F] fluspidine fallypride PET, purpose of this study assess vivo target engagement/receptor occupancy D2/D3 (D2/D3R) at clinical relevant doses healthy volunteers (HVs) proof-of-concept small number patients with...
We report on results from the fully diode-pumped chirped-pulse amplification laser system Polaris. Pulses were amplified to a maximum energy of 54.2 J before compression. These pulses have full width at half-maximum spectral bandwidth 18 nm centered 1033 and are generated repetition rate 0.02 Hz. To best our knowledge, these most energetic broadband by so far. Due limited size vacuum compressor, only attenuated could be compressed duration 98 fs containing an 16.7 J, which leads peak power...
Abstract We report on the successful implementation and characterization of a cryogenic solid hydrogen target in experiments high-power laser-driven proton acceleration. When irradiating filament 10 μm diameter with 10-Terawatt laser pulses 2.5 J energy, protons kinetic energies excess 20 MeV exhibiting non-thermal features their spectrum were observed. The emitted into large angle reaching total conversion efficiency several percent. Two-dimensional particle-in-cell simulations confirm our...
Abstract Functional changes of nicotinic acetylcholine receptors (nAChR) are important during age‐related neuronal degeneration. Recent studies demonstrate the applicability nAChR ligand 2‐[ 18 F]F‐A‐85380 for neuroimaging patients with dementias. However, its binding kinetics demands a 7‐h acquisition time limiting practicality clinical PET studies. Thus, authors developed [ F]norchloro‐fluoro‐homoepibatidine ([ F]NCFHEB) imaging. The two enantiomers F]NCFHEB were compared F]F‐A85380 in...
Accurate amyloid PET quantification is necessary for monitoring amyloid-β accumulation and response to therapy. Currently, most of the studies are analyzed using static SUV ratio (SUVR) approach because its simplicity. However, this may be influenced by changes in cerebral blood flow (CBF) or radiotracer clearance. Full tracer kinetic models require arterial sampling dynamic image acquisition. The objectives work were, first, validate a noninvasive modeling <sup>18</sup>F-florbetaben an...
Abstract A dual positron emission tomography (PET) tracer study with [18F]fluoride and the freely diffusible [15O]H2O was performed to measure capillary transport of evaluate potential ion PET quantitate bone blood flow. Under condition a high predictable single-pass extraction fraction (EF) for [18F]fluoride, influx constant (K1F), derived from kinetic measurements, can be used estimate Bone flow measured in vertebral bodies by dynamic during continuous ventilation N2O, O2, Isoflurane (FiO2...
Because of their involvement in growth and survival signaling cascades, the σ<sub>1</sub> receptors (σ<sub>1</sub>Rs) represent a novel target for treatment cancer several brain diseases such as depression neurodegeneration. From series σ<sub>1</sub>R-specific <sup>18</sup>F-fluoroalkylated spirocyclic piperidines, we have chosen <sup>18</sup>F-fluspidine detailed investigation vivo kinetics (<i>R</i>)-(+)- (<i>S</i>)-(–)-enantiomers to identify potential imaging humans. <b>Methods:</b>...