A5039738060- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Regulation of Appetite and Obesity
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- Hepatitis C virus research
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- HIV/AIDS drug development and treatment
- Mental Health Research Topics
- Agriculture Sustainability and Environmental Impact
- Chronic Lymphocytic Leukemia Research
- Workplace Health and Well-being
Leipzig University
2016-2025
Max Planck Institute for Human Cognitive and Brain Sciences
2016-2025
University Hospital Leipzig
2017-2025
Brigham and Women's Faulkner Hospital
2025
Max Planck Institute for Empirical Aesthetics
2024
Universität Hamburg
2023-2024
Brigham and Women's Hospital
2024
HAW Hamburg
2023-2024
University Medical Center
2023
Max Planck Society
2015-2022
Animal studies suggest that diets low in calories and rich unsaturated fatty acids (UFA) are beneficial for cognitive function age. Here, we tested a prospective interventional design whether the same effects can be induced humans. Fifty healthy, normal- to overweight elderly subjects (29 females, mean age 60.5 years, body mass index 28 kg/m 2 ) were stratified into 3 groups: ( i caloric restriction (30% reduction), ii relative increased intake of UFAs (20% increase, unchanged total fat),...
Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies older humans are lacking. Here, we tested whether supplementation of would enhance adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight individuals successfully completed 26 weeks intake (200 mg/d)...
Higher intake of seafish or oil rich in long-chain omega-3 polyunsaturated fatty acids (LC-n3-FA) may be beneficial for the aging brain. We tested a prospective interventional design whether high levels supplementary LC-n3-FA would improve cognition, and addressed potential mechanisms underlying effects. Sixty-five healthy subjects (50–75 years, 30 females) successfully completed 26 weeks either fish (2.2 g/day LC-n3-FA) placebo intake. Before after intervention period, cognitive...
For this cross-sectional study, we aimed to elucidate whether higher glycosylated hemoglobin (HbA1c) and glucose levels exert a negative impact on memory performance hippocampal volume microstructure in cohort of healthy, older, nondiabetic individuals without dementia.In 141 (72 women, mean age 63.1 years ± 6.9 SD), was tested using the Rey Auditory Verbal Learning Test. Peripheral fasting HbA1c, glucose, insulin 3-tesla MRI scans were acquired assess microstructure, as indicated by gray...
White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. quantified volume among participants a community dwelling cohort ( n = 702, age range 60 - 82 years, mean 69.5 46% female) and investigated effects behavior, specifically for executive function, memory, motor speed performance. Lesion location influenced their effect behavior: Frontal proximity frontal ventricles...
White matter hyperintensities (WMHs) are linked to vascular risk factors and increase the of cognitive decline, dementia, stroke. We here aimed determine whether obesity contributes regional WMHs using a whole-brain approach in well-characterized population-based cohort.Waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes smoking status, glucose inflammatory markers, as well distribution WMH were assessed 1,825 participants LIFE-adult...
As the process of Alzheimer's disease (AD) begins years before onset, searching for prevention strategies is major medical and economic importance. Nutritional supplementation with long-chain polyunsaturated omega-3 fatty acids (LC-n3-FA) may exert beneficial effects on brain structure a nd function. However, experimental evidence in older adults without clinical dementia inconsistent, possibly due to low sensitivity previously employed test batteries detecting subtle improvements cognition...
Dietary modifications such as caloric restriction (CR) have been suggested a means to improve memory and prevent age-related decline. However, it is unclear whether those effects remain stable over time or are related specifically negative energy balance during the weight loss phase of CR. Using randomized interventional design, we investigated changes in recognition neural correlates postmenopausal obese women (n = 19): 1) after intense course 12-week low-caloric diet (reduced body balance)...
Abstract The gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed explore if specific bacterial genera relate eating behavior, diet, and SCFA adults. Moreover, we tested whether eating-related microbiota treatment success patients after Roux-en-Y gastric bypass (RYGB). Anthropometrics, dietary fiber intake, 16S-rRNA-derived microbiota, fecal...
Social isolation has negative effects on physical and brain health across the lifespan. However, prevalence of social isolation, specifically with regard to sociodemographic socioeconomic factors, is not well known.Database was Leipzig population-based study adults (LIFE-Adult Study, n = 10,000). The short form Lubben Network Scale (LSNS-6) used assess (cutoff < 12 points). Sampling weights were applied account for differences in sampling fractions.Data available 9392 participants; 51.6%...
The effect of diet on age-related brain atrophy is largely unproven.We aimed to explore the a Mediterranean (MED) higher in polyphenols and lower red/processed meat (Green-MED diet) atrophy.This 18-mo clinical trial longitudinally measured structure volumes by MRI using hippocampal occupancy score (HOC) lateral ventricle volume (LVV) expansion as neurodegeneration markers. Abdominally obese/dyslipidemic participants were randomly assigned follow 1) healthy dietary guidelines (HDG), 2) MED,...
While many structural and biochemical changes in the brain have previously been associated with older age, findings concerning functional properties of neuronal networks, as reflected their electrophysiological signatures, remain rather controversial.These discrepancies might arise due to several reasons, including diverse factors determining general spectral slowing alpha frequency range well amplitude mixing between rhythmic non-rhythmic parameters.We used a large dataset ( N = 1703, mean...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Substantial evidence indicates a huge potential for risk reduction of cognitive decline and dementia based on modifiable health lifestyle factors. To maximize the chances reduction, it is useful to investigate associations social determinants brain health. We computed "LIfestyle BRAin health" (LIBRA) score baseline participants Leipzig Research Centre Civilization Diseases (LIFE) Adult Study, population-based urban cohort in Germany. LIBRA predicts midlife early late life populations,...
Abstract Ovarian hormones have substantial effects on the brain, and early menopause has been associated with increased risk of accelerated brain aging dementia later in life. However, impact ovarian hormone fluctuations structure earlier life is less understood. Here we show that shape structural plasticity during reproductive years. We use longitudinal ultra-high field neuroimaging across menstrual cycle to map morphology medial temporal lobe subregions 27 participants. Controlling for...