A5089605028- Health Systems, Economic Evaluations, Quality of Life
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Statistical Methods in Clinical Trials
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Economic and Financial Impacts of Cancer
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Photodynamic Therapy Research Studies
- Cancer Genomics and Diagnostics
- Advanced Causal Inference Techniques
- COVID-19 Clinical Research Studies
- Barrier Structure and Function Studies
- EEG and Brain-Computer Interfaces
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Psychosomatic Disorders and Their Treatments
- Brain Tumor Detection and Classification
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- MRI in cancer diagnosis
- Neonatal and fetal brain pathology
Rabin Medical Center
2023-2025
Tel Aviv University
2024
Ben-Gurion University of the Negev
2017-2022
Soroka Medical Center
2019
Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying transition from young-and-healthy aged-and-dysfunctional brain are not well understood. Here, we report breakdown of vascular blood-brain barrier (BBB) aging humans rodents, which begins as early middle age progresses end life span. Gain-of-function loss-of-function manipulations show this BBB dysfunction triggers hyperactivation transforming growth factor-β...
A growing body of evidence shows that epileptic activity is frequent but often undiagnosed in patients with Alzheimer's disease (AD) and has major therapeutic implications. Here, we analyzed electroencephalogram (EEG) data from AD found an EEG signature transient slowing the cortical network termed paroxysmal slow wave events (PSWEs). The occurrence per minute PSWEs was correlated level cognitive impairment. Interictal (between seizures) were also epilepsy, localized to regions displaying...
The effect of diet on age-related brain atrophy is largely unproven.We aimed to explore the a Mediterranean (MED) higher in polyphenols and lower red/processed meat (Green-MED diet) atrophy.This 18-mo clinical trial longitudinally measured structure volumes by MRI using hippocampal occupancy score (HOC) lateral ventricle volume (LVV) expansion as neurodegeneration markers. Abdominally obese/dyslipidemic participants were randomly assigned follow 1) healthy dietary guidelines (HDG), 2) MED,...
Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive injury-induced neurodegeneration are unknown and antemortem diagnostic tests not available, neuropathology studies suggest pathogenic role for microvascular injury, specifically blood-brain barrier dysfunction. Thus, our main objective was to demonstrate effectiveness...
Postinjury epilepsy (PIE) is a devastating sequela of various brain insults. While recent studies offer novel insights into the mechanisms underlying epileptogenesis and discover potential preventive treatments, lack PIE biomarkers hinders clinical implementation such treatments. Here we explored biomarker different electrographic features in five models PIE. Electrocorticographic or intrahippocampal recordings (from insult to first spontaneous seizure) from two laboratories were analyzed...
Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence acute ischemia on MRI diffusion-weighted imaging highly variable confirmed in only about one-third patients. This study investigated the significance blood-brain barrier dysfunction (BBBD) mapping patients with neurological deficits, as a diagnostic prognostic biomarker required for risk stratification stroke prevention. Methods- We used dynamic contrast-enhanced to quantitatively map BBBD prospective...
Importance Three similar phase 3 randomized clinical trials have investigated PD-1/PD-L1 (programmed cell death 1 protein/programmed ligand 1) inhibitors in combination with platinum-based chemotherapy vs alone as first-line treatment for advanced urothelial carcinoma (IMvigor130, atezolizumab; KEYNOTE-361, pembrolizumab; and CheckMate901, nivolumab). Only CheckMate901 reported overall survival (OS) benefit the combination. The reason these inconsistent results is unclear. Objective To...
Abstract BACKGROUND In late 2016, US diplomats stationed in Havana began presenting with a variety of neurological manifestations that proved difficult to diagnose. Though previous studies suggested likely association brain injury, the mechanism regions involved, and etiology remained unknown. METHODS We conducted multimodal study examining 26 Canadian their family members, majority whom presented symptoms similar American counterparts while residing Havana. Assessments included medical...
Statistical significance currently defines superiority in phase III oncology trials. However, this practice is increasingly questioned. Here, we estimated the fragility of Using Kaplan-Meier curves for primary endpoints 230 two-arm trials, reconstructed data individual patients. We survival-inferred index (SIFI) by iteratively flipping best responder from experimental arm to control (SIFI B ) until interpretation was changed according threshold each trial. Severe defined SIFI ≤ 1%. This...
Abstract The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion syndrome, post-impact catastrophic death, and delayed neurodegeneration remain poorly understood. This limited pathophysiological understanding has hindered development diagnostic prognostic biomarkers prevented advancement treatments for sequelae injury. We aimed to characterize early electrophysiological neurovascular alterations following repetitive injury sought identify new...
Abstract Objective Management of a patient presenting with first seizure depends on the risk additional seizures. In clinical practice, recurrence is estimated by treating physician using neurological examination, brain imaging, thorough history for factors, and routine scalp electroencephalogram (EEG) to detect abnormal epileptiform activity. The decision use antiseizure medication can be challenging when objective findings are missing. There need new biomarkers better diagnose epilepsy...
This cohort study compares the mortality and hospitalization risks among patients with vs without solid cancer diagnosed COVID-19 during period when Omicron variant was dominant.
Abstract Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying transition from young-and-healthy aged-and-dysfunctional brain are not well understood. Here, we report breakdown of vascular blood-brain barrier (BBB) aging humans rodents, which begins as early middle age progresses end lifespan. Gain-of-function loss-of-function manipulations show this BBB dysfunction triggers hyperactivation transforming growth...
Abstract BACKGROUND Brain radiation necrosis (RN) is a frequent and severe complication of stereotactic radiotherapy, which an effective common treatment for brain metastases (BM). There no standard RN Bevacizumab (Bev) has emerged as potential treatment, due to its anti-angiogenic properties. Data regarding the long-term efficacy Bev are scarce. We performed retrospective study evaluate immediate impact on patients with following therapy. MATERIAL AND METHODS reviewed all adult treated...
Abstract Background Meningiomas are the most common primary tumor in central nervous system. About 15%–20% aggressive and tend to recur progress despite conventional treatment. Bevacizumab has been found be effective treatment of refractory meningiomas retrospective studies. The Response Assessment Neuro-Oncology (RANO) criteria widely used assess effect Recent studies suggest that 3D volumetric growth rate (3DVGR) may more accurate for irregularly shaped tumors. aim this study was compare...
e15609 Background: Colorectal cancer (CRC) is one of the leading causes death globally, with more than 0.9 million deaths annually. Despite screening programs, many CRC patients (pts) are diagnosed at an advanced stage, resulting in overall 5-year survival rate only about 60%. Enhancing detection pts referred to Emergency Room (ER) could potentially improve early and outcomes. While prevalence initial diagnoses obtained through ER admission documented, proportion individuals who visited...
1573 Background: The survival-inferred fragility index (SIFI) quantifies the robustness of positive trials by estimating number changes in a survival analysis that would render results insignificant. Here, we use variation SIFI (SIFI-median) which median patient is reassigned between study groups until significance lost. Our goal was to oncology randomized controlled (RCTs) leading drug approval FDA based on surrogate time-to-event endpoints. Methods: In this cross-sectional study,...
Abstract PURPOSE Brain radionecrosis (RN) is a frequent, and often life devastating complication of stereotactic radiotherapy (SRS) for brain metastases. There no standard treatment RN. Bevacizumab proposed although data regarding its efficacy limited. We performed retrospective study to evaluate the short long-term bevacizumab in METHODS included all patients who received RN developed after with SRS Patients treated our institution between 31/07/2018 31/07/2022 were enrolled into study....
Objective: To assess blood-brain barrier dysfunction (BBBD) mapping in patients with transient neurological deficit, as a diagnostic and predictive biomarker required for risk stratification stroke prevention. Background: The diagnosis of ischemic attack (TIA) is challenging. Evidence acute ischemia on diffusion-weighted imaging (DWI) highly variable confirmed only about one-third patients. BBBD prominent feature cerebral key mechanism underlying delayed complications. Yet, to date, no...