A5084888937- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Pelvic floor disorders treatments
- SARS-CoV-2 and COVID-19 Research
- Urinary Bladder and Prostate Research
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Antibiotics Pharmacokinetics and Efficacy
- Potassium and Related Disorders
- Patient Satisfaction in Healthcare
- Pharmaceutical Practices and Patient Outcomes
- Meta-analysis and systematic reviews
- Healthcare cost, quality, practices
- Renal Transplantation Outcomes and Treatments
- Antibiotic Resistance in Bacteria
- Pediatric Urology and Nephrology Studies
- Frailty in Older Adults
- Advanced Causal Inference Techniques
- Genetic Associations and Epidemiology
- Nosocomial Infections in ICU
- Pituitary Gland Disorders and Treatments
Rabin Medical Center
2018-2025
Tel Aviv University
2018-2025
Arthur M. Sackler Gallery
2021
Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration antibiotic therapy are limited.This was randomized, multicenter, open-label, noninferiority trial. Inpatients with gram-negative bacteremia, who were afebrile hemodynamically stable for at least 48 hours, randomized receive 7 days (intervention) or 14 (control) covering therapy. Patients uncontrolled focus infection excluded. The primary outcome 90 composite all-cause...
The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for lower urinary tract infection (UTI).To compare the clinical microbiologic efficacy in women with uncomplicated cystitis.Multinational, open-label, analyst-blinded, randomized trial including 513 nonpregnant aged 18 years older symptoms UTI (dysuria, urgency, frequency, or suprapubic tenderness), a positive urine dipstick result (with detection nitrites leukocyte...
Background. Glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce cardiovascular events and mortality in type 2 diabetes. Limited data are available on diabetes treatment after solid organ transplantation. We aimed to explore the effect of GLP1-RAs outcomes transplanted recipients with Methods. extracted adult transplant (kidney, lungs, liver, heart) insured a large health maintenance organization. Death-censored patients treated were matched nonusers. The primary outcome was composite...
We aim to compare the effect of short versus long treatment duration in Gram-negative bacteremia on all-cause mortality pre-specified sub-groups.Individual participant data meta-analysis randomized controlled trials (RCTs) comparing (≤7) longer (>7 days) antibiotic for bacteremia. Participants were adults (≥18 years), with during hospital stay. searched PubMed, Cochrane Central Register Controlled Trials, and Web Science identify conducted up May 2022. Primary outcome was 90-day mortality....
Abstract Objective To investigate the impact of Sodium-glucose cotransporter 2 (SGLT2) inhibitors on incidence, complications, and therapeutic demands anemia in patients with diabetes utilizing real-world data, compared to treatment dipeptidyl peptidase 4 (DPP4) inhibitors. Patients Methods In this retrospective cohort study, dataset was sourced from data repositories Clalit Health Services. Since January 1, 2016 through December 31, 2021 we identified type who received SGLT2 them a matched...
OBJECTIVE To describe disparities in prescribing and dispensing sodium–glucose cotransporter 2 inhibitors (SGLT2i) Israel. RESEARCH DESIGN AND METHODS This was a population-based retrospective cohort study of adults with type diabetes eligible for SGLT2i treatment from 2017 to 2023. The primary outcome the time between initial eligibility first prescription SGLT2i. RESULTS Among 32,742 patients, only 53% were prescribed Multivariable analyses, adjusting death as competing risk, revealed...
The optimal treatment for extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae bloodstream infections has yet to be defined. Retrospective studies have shown conflicting results, with most data suggesting the non-inferiority of beta-lactam-beta-lactamase inhibitor combinations compared carbapenems. However, recently published MERINO trial failed demonstrate piperacillin-tazobactam meropenem. potential implications are profound, as widespread adoption carbapenem will detrimental...
Although a short course (7 days) of antibiotics has been demonstrated to be noninferior conventional (14 in terms mortality and infectious complications for patients with Gram-negative bacterial bloodstream infection (GNB), it is unknown whether shorter treatment duration can provide better overall clinical outcome.We applied infection-specific desirability outcome ranking (DOOR) analysis the results previously completed, randomized controlled trial comparing versus antibiotic therapy...
Abstract Objective Multiple cases and case series reported Graves’ disease (GD) following coronavirus 2019 (COVID-19) vaccination. We aimed to determine whether COVID-19 vaccination was associated with the incidence of GD. Methods analyzed data from Clalit Health Services, largest healthcare organization in Israel, which insures 4.7 million patients. A population-based, matched, case-control study performed. Cases were defined as adult patients diagnosed GD between December 2020 November...
Alpha 1 antitrypsin (A1AT) is the major human blood serine protease inhibitor. Transmembrane 2 (TMPRSS2), which crucial for SARS-CoV-2 cell entry, inhibited by A1AT. Therefore, we hypothesized that individuals with diminished levels of A1AT may be more prone to infection and severe COVID-19 disease. Our aim in this study was evaluate level hospitalized patients comparison non-COVID-19 pneumonia.We conducted an observational prospective between October 2020 April 2021 Rabin Medical Centre...
This cohort study compares the mortality and hospitalization risks among patients with vs without solid cancer diagnosed COVID-19 during period when Omicron variant was dominant.
Hospital readmissions following severe infections are a major economic burden on the health care system and have negative influence patients' quality of life. Understanding risk factors for readmission, particularly extent to which they could be prevented, is great importance. In this study we evaluated potentially preventable 60-day readmission in patients surviving hospitalization complicated urinary tract infection (cUTI). This was multinational, multicentre retrospective cohort conducted...
Abstract Background Population external validity is the extent to which an experimental study results can be generalized from a specific sample defined population. In order apply of study, we should able assess its population validity. We performed investigator-initiated randomized controlled trial (RCT) (AIDA study), compared colistin-meropenem combination therapy colistin monotherapy in treatment patients infected with carbapenem-resistant Gram-negative bacteria. examine study’s and...
Given rising antibiotic resistance and increasing use of delayed prescription for uncomplicated lower urinary tract infections (UTI), patients at risk treatment failure should be identified early. We assessed factors clinical microbiological in women with UTI. This case-control study nested within a randomized trial included all the per-protocol population (PPP), those PPP microbiologically confirmed UTI, UTI due to Escherichia coli. Cases were who experienced and/or microbiologic failure;...
(Abstracted from JAMA 2018;319:1781–1789) Guidelines for the treatment of uncomplicated lower urinary tract infections (UTIs) were modified in 2010 because increasing antimicrobial resistance. The new guidelines recommend nitrofurantoin and fosfomycin as first-line agents.
A large-scale retrospective case-control study.
<p dir="ltr">Objective: To describe disparities in prescribing and dispensing Sodium-glucose Cotransporter-2 Inhibitors (SGLT2i) Israel.</p><p dir="ltr">Research Design Methods: A population-based retrospective cohort study of adults with type 2 diabetes mellitus eligible for SGLT2i treatment from 2017 to 2023. The primary outcome was time between initial eligibility first prescription SGLT2i. </p><p dir="ltr">Results: Among 32,742 patients, only 53% were...