Yizhuo Shen

ORCID: 0000-0003-4453-0719
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About
Contact & Profiles
Research Areas
  • Barrier Structure and Function Studies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Reconstructive Surgery and Microvascular Techniques
  • Breast Implant and Reconstruction
  • Diversity and Career in Medicine
  • Long-Term Effects of COVID-19
  • Radiomics and Machine Learning in Medical Imaging
  • Reconstructive Facial Surgery Techniques
  • Immunotherapy and Immune Responses
  • Cardiac, Anesthesia and Surgical Outcomes
  • Lysosomal Storage Disorders Research
  • S100 Proteins and Annexins
  • Sphingolipid Metabolism and Signaling
  • Anatomy and Medical Technology
  • SARS-CoV-2 and COVID-19 Research
  • Artificial Intelligence in Healthcare and Education
  • Cytokine Signaling Pathways and Interactions
  • Hippo pathway signaling and YAP/TAZ
  • COVID-19 Clinical Research Studies
  • Ubiquitin and proteasome pathways
  • Erythrocyte Function and Pathophysiology
  • Body Image and Dysmorphia Studies
  • Facial Nerve Paralysis Treatment and Research
  • interferon and immune responses
  • Facial Rejuvenation and Surgery Techniques

Yale Cancer Center
2025

UCSF Benioff Children's Hospital
2025

Harvard University
2024

Creative Commons
2023

The First People's Hospital of Xiaoshan District, Hangzhou
2020

University of California, Berkeley
2019

Recent studies have focused on initial clinical and epidemiological characteristics of the coronavirus disease 2019 (COVID-19), which is mainly revealing situation in Wuhan, Hubei.

10.1093/qjmed/hcaa089 article EN cc-by-nc QJM 2020-03-14

Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying transition from young-and-healthy aged-and-dysfunctional brain are not well understood. Here, we report breakdown of vascular blood-brain barrier (BBB) aging humans rodents, which begins as early middle age progresses end life span. Gain-of-function loss-of-function manipulations show this BBB dysfunction triggers hyperactivation transforming growth factor-β...

10.1126/scitranslmed.aaw8283 article EN Science Translational Medicine 2019-12-04

Lower-third facial feminization procedures have been associated with the development of postoperative jowling, yet quantitative evaluations this outcome remain limited. This study evaluated relationship between patient risk factors and bony volume reduction jowling. Chin gonial angle measurements were obtained from preoperative computed tomography imaging, whereas changes in jowling assessed using a validated photonumeric scale on images. Associations skeletal changes, demographic variables,...

10.1097/scs.0000000000011132 article EN Journal of Craniofacial Surgery 2025-02-03

Gadiraju, Goutam K. B.S.; Gao, Renee Malek, Andrew J. Shen, Yizhuo M.M.Sc.; Broyles, Justin M. M.D., M.P.H. Author Information

10.1097/prs.0000000000012004 article EN Plastic & Reconstructive Surgery 2025-02-04

Breast reconstruction is a critical component of breast cancer treatment. With the rapid integration Artificial Intelligence (AI) into healthcare, its potential to revolutionize has become increasingly evident. This narrative review examines latest AI developments across preoperative, intraoperative, and postoperative phases reconstruction. In preoperative consultations, augmented reality (AR)-driven simulations help both surgeons patients visualize outcomes. Imaging analysis predictive...

10.20517/ais.2024.71 article EN Artificial Intelligence Surgery 2025-03-10

<title>Abstract</title> Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of progression and mechanisms transition more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional deregulation is central all malignancies, highlighted by the extensive reprogramming regulatory elements that underlie oncogenic programs. Among these, super-enhancers (SEs) stand out due their enrichment in...

10.21203/rs.3.rs-6240646/v1 preprint EN cc-by Research Square (Research Square) 2025-03-31

Abstract Background Rippling remains one of the most common complications following prepectoral implant-based reconstruction (IBR). Objectives The purpose this study was to assess how implant cohesivity, a measure elasticity and form stability, affects incidence rippling in IBR. Methods We performed retrospective cohort 2-stage IBR between January 2020 June 2022 at Brigham Women's Hospital Dana-Farber Cancer Institute, comparing outcomes patients who received Allergan Natrelle least...

10.1093/asjof/ojae028 article EN cc-by Aesthetic Surgery Journal Open Forum 2024-01-01

Abstract Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying transition from young-and-healthy aged-and-dysfunctional brain are not well understood. Here, we report breakdown of vascular blood-brain barrier (BBB) aging humans rodents, which begins as early middle age progresses end lifespan. Gain-of-function loss-of-function manipulations show this BBB dysfunction triggers hyperactivation transforming growth...

10.1101/537431 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2019-02-01

Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of progression and mechanisms transition more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional deregulation is central all malignancies, highlighted by the extensive reprogramming regulatory elements that underlie oncogenic programs. Among these, super-enhancers (SEs) stand out due their enrichment in genes controlling...

10.1101/2024.09.21.614267 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-09-24

PURPOSE: Implant based reconstruction (IBR) can include prepectoral or sub-pectoral reconstruction.[1] While up to 50% of plastic surgeons perform IBR, implant rippling secondary poor superior pole coverage is a common postoperative complaint from patients.[2] Silicone implants that are used in these procedures vary cohesivity. In the plane, it suspected highly cohesive reduce rates; however, this has not yet been demonstrated. METHODS & MATERIALS: A retrospective cohort analysis two-stage...

10.1097/01.gox.0000992372.02494.86 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2023-10-01
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