A5102761481- Diet and metabolism studies
- Legal principles and applications
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Functional Brain Connectivity Studies
- Conflict of Laws and Jurisdiction
- Gout, Hyperuricemia, Uric Acid
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Nuts composition and effects
- Dietary Effects on Health
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Adrenal Hormones and Disorders
Sheba Medical Center
2021-2025
Ben-Gurion University of the Negev
2017-2025
Tel Aviv University
2022-2024
Tel Aviv Sourasky Medical Center
2022
Soroka Medical Center
2021
Hachaklait (Israel)
2020
Faculty of Public Health
2020
In-Q-Tel
2020
Southlake Regional Health Center
2009
Magen David Adom
2003
Objective To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss. Design For DIRECT-PLUS 18-month randomized clinical trial, we assigned 294 participants abdominal obesity/dyslipidaemia into healthy dietary guidelines (HDG), MED green-MED weight-loss diet groups, all accompanied physical activity. Both isocaloric...
Background & AimsWe evaluated the efficacy and safety of diet-modulated autologous fecal microbiota transplantation (aFMT) for treatment weight regain after weight-loss phase.MethodsIn DIRECT PLUS (Dietary Intervention Randomized Controlled Trial Polyphenols-Unprocessed) trial (May 2017 through July 2018), abdominally obese or dyslipidemic participants in Israel were randomly assigned to healthy dietary guidelines, Mediterranean diet, green-Mediterranean diet groups. All groups received free...
Previous studies have linked the Mediterranean diet (MED) with improved cardiometabolic health, showing preliminary evidence for a mediating role of gut microbiome. We recently suggested Green-Mediterranean (Green-MED) as an version healthy MED diet, increased consumption plant-based foods and reduced meat intake. Here, we investigated effects interventions on microbiota markers, interplay between two, during initial weight loss phase DIRECT-PLUS trial.In study, 294 participants abdominal...
Background: Rare plants that contain corrinoid compounds mostly comprise cobalamin analogues, which may compete with (vitamin B12 (B12)) metabolism. We examined the presence of in a cultivated strain an aquatic plant: Wolffia globosa (Mankai), and predicted functional pathways using gut-bioreactor, effects long-term Mankai consumption as partial meat substitute, on serum concentrations. Methods: used microbiological assay,...
The effect of diet on age-related brain atrophy is largely unproven.We aimed to explore the a Mediterranean (MED) higher in polyphenols and lower red/processed meat (Green-MED diet) atrophy.This 18-mo clinical trial longitudinally measured structure volumes by MRI using hippocampal occupancy score (HOC) lateral ventricle volume (LVV) expansion as neurodegeneration markers. Abdominally obese/dyslipidemic participants were randomly assigned follow 1) healthy dietary guidelines (HDG), 2) MED,...
Abstract Background Mediterranean (MED) diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. We explored the effect green-MED diet, twice fortified in dietary polyphenols and lower red/processed meat, on visceral adipose tissue (VAT). Methods In 18-month Dietary Intervention Randomized Controlled Trial PoLyphenols UnproceSsed (DIRECT-PLUS) weight-loss trial, 294 participants were randomized to (A) healthy guidelines (HDG), (B) MED, or (C) diets, all combined...
Abstract Background Visceral adipose tissue (VAT) is well established as a pathogenic fat depot, whereas superficial subcutaneous (SAT) associated with either an improved or neutral cardiovascular state. However, it unclear to what extent VAT area (VATcm 2 ) and its proportion of total abdominal (VAT%) are distinguished in predicting cardiometabolic status clinical outcomes during weight loss. Methods We integrated magnetic resonance imaging (MRI) measurements VAT, deep-SAT, superficial-SAT...
Epigenetic age is an estimator of biological based on DNA methylation; its discrepancy from chronologic warrants further investigation. We recently reported that greater polyphenol intake benefitted ectopic fats, brain function, and gut microbiota profile, corresponding with elevated urine polyphenols. The effect polyphenol-rich dietary interventions aging yet to be determined.We calculated different epigenetic clocks generations (Horvath2013, Hannum2013, Li2018, Horvath skin blood2018,...
<h2>Abstract</h2><h3>Background</h3> The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo is partly unknown. Given beneficial metabolic effects Mediterranean (MED) enriched polyphenols and reduced red/processed meat (green-MED), as previously been proven by 18-month DIRECT PLUS randomized controlled trial, we analyzed green-MED on methylome transcriptome levels highlight molecular mechanisms underlying observed improvements. <h3>Methods</h3> Our study included 260...
Abstract Background DNA methylation age (mAge), a biomarker for the aging process, might serve as more accurate predictor of morbidity and status than chronological age. We evaluated role multiple factors, including fat deposition, cardiometabolic risk factors lifestyle weight-loss intervention, on deviation mAge from (mAge deviation) or 18-month change in (∆mAge). In this sub-study CENTRAL magnetic resonance imaging trial, we by validated 240-CpG-based prediction formula at baseline after...
To compare the postprandial and overnight glycemic response using a novel green aquatic plant thought to provide dietary source for high-quality protein, with an iso-carbohydrate/protein/caloric dairy shake.This is randomized controlled crossover trial among 20 abdominally obese participants (age 51.4 years; fasting plasma glucose 110.9 mg/dL), who were allocated replace dinner either, first, shake containing Wolffia globosa duckweed (Mankai: specific-strain) or...
We aim to assess changes in routine echocardiographic and longitudinal strain parameters patients recovering from Coronavirus disease 2019 during hospitalization at 3-month follow-up.Routine comprehensive echocardiography STE of both ventricles were performed for acute coronavirus (COVID-19) infection as part a prospective pre-designed protocol compared with ∼3 months after recovery 80 patients, using similar protocol. Significantly improved right ventricle (RV) fractional area change,...
Obesity negatively impacts multiple bodily systems, including the central nervous system. Retrospective studies that estimated chronological age from neuroimaging have found accelerated brain aging in obesity, but it is unclear how this estimation would be affected by weight loss following a lifestyle intervention.In sub-study of 102 participants Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT-PLUS) trial, we tested effect 18 months intervention on...
We previously reported that autologous-fecal-microbiota-transplantation (aFMT), following 6 m of lifestyle intervention, attenuated subsequent weight regain and insulin rebound for participants consuming a high-polyphenol green-Mediterranean diet. Here, we explored whether specific changes in the core (abundant) vs. non-core (low-abundance) gut microbiome taxa fractions during weight-loss phase (0-6 m) were differentially associated with maintenance aFMT. Eighty-two abdominally...
Abstract Obesity is associated with negative effects on the brain. We exploit Artificial Intelligence (AI) tools to explore whether differences in clinical measurements following lifestyle interventions overweight population could be reflected brain morphology. In DIRECT‐PLUS trial, participants criterion for metabolic syndrome underwent an 18‐month intervention. Structural MRIs were acquired before and after utilized ensemble learning framework predict Body‐Mass Index (BMI) scores, which...
A 36-year-old male with diffuse large B-cell lymphoma on maintenance rituximab therapy presented to the emergency department high fever and fatigue. chest X-ray showed a lobar infiltrate, 40 days before admission patient suffered from mild coronavirus disease 2019 (COVID-19) infection fully recovered. PCR nasopharyngeal swab was negative for COVID-19. Comprehensive biochemical, radiological, pathological evaluation including 18-fluorodeoxyglucose positron emission tomography computed...
Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of
Background and Aims: We demonstrated in the randomized 18-month DIRECT PLUS trial (n = 294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, walnuts restricted red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared 2 other healthy diets, reducing NAFLD by half, regardless of similar weight loss. Here, we investigated baseline proteomic profile associated IHF% changes proteomics induced lifestyle intervention. Approach...
As populations age, sarcopenia increasingly impacts healthcare due to its associations with morbidity, mortality, and cognitive decline. This study is a cross-sectional analysis of prospectively collected data from 140 older adults hospitalized in an internal medicine department. Sarcopenia was measured by handgrip strength, function the Digit Symbol Substitution Test (DSST). Sarcopenic patients (n=78) had lower DSST scores (p=0.003) Norton (p&;lt0.001) compared non-sarcopenic patients....
Abstract Background and Aims In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epigenetic mechanisms may contribute intraindividual variation. Moreover, genetic factors are involved developing nonalcoholic fatty‐liver disease (NAFLD), a reflected by an increase intrahepatic (IHF). this exploratory analysis, primarily aimed examine effect of lifestyle interventions on DNA‐methylation NAFLD related genes associated with IHF....