Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study

• DOI: 10.14336/ad.2024.1676
• Publication Date: 2025-03-25T14:47:23Z
• Authors: Sapir Kon-Kfir; Tali Cukierman‐Yaffe; Haim Krupkin; Ana Belkin; Gadi Shlomai; Jonathan Bleier; Shiri Weinstein; Liora Bruckmayer; Elad Prinz; Alon Kaplan; Michal Goldenberg...; Dana Lev; S. Dekel; Noa Shalmon; Nurit Tsarfaty; Niv Reiss; Evelyne Bischof; Avshalom Leibowitz
• Keywords: Cognitive Decline

As populations age, sarcopenia increasingly impacts healthcare due to its associations with morbidity, mortality, and cognitive decline. This study is a cross-sectional analysis of prospectively collected data from 140 older adults hospitalized in an internal medicine department. Sarcopenia was measured by handgrip strength, function the Digit Symbol Substitution Test (DSST). Sarcopenic patients (n=78) had lower DSST scores (p=0.003) Norton (p&;lt0.001) compared non-sarcopenic patients. Handgrip strength showed significant positive correlation (R=0.26, p=0.0019), persisting after adjustments for age sex (R=0.42, p=1.7e-07). underscores association between decline adults, advocating routine assessments upon admission. These findings emphasize importance identifying at-risk early developing targeted interventions. Future research should further explore underlying mechanisms validate broader cohorts.