A5019320580- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Poisoning and overdose treatments
- Attention Deficit Hyperactivity Disorder
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Schizophrenia research and treatment
- Chemical synthesis and alkaloids
- Stress Responses and Cortisol
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Pharmacological Effects and Assays
- Epilepsy research and treatment
- Electroconvulsive Therapy Studies
- Forensic Toxicology and Drug Analysis
- Neurological Disorders and Treatments
Leipzig University
2015-2024
University of Haifa
2021
University of Tübingen
2021
Max Planck Institute for Human Cognitive and Brain Sciences
2021
University of Pittsburgh
2021
Transylvania University of Brașov
2021
Institute of Pharmacology
2013-2020
Louvre
2015
MRC Cognition and Brain Sciences Unit
2009
Noradrenergic dysfunction may play a significant role in cognition Parkinson’s disease due to the early degeneration of locus coeruleus. Converging evidence from patient and animal studies points noradrenaline dopaminergically insensitive aspects parkinsonian dysexecutive syndrome, yet direct effects noradrenergic enhancement have not date been addressed. Our aim was directly investigate these, focusing on impulsivity during response inhibition decision making. To this end, we administered...
Impulsivity is common in Parkinson’s disease even the absence of impulse control disorders. It likely to be multifactorial, including a dopaminergic ‘overdose’ and structural changes frontostriatal circuits for motor control. In addition, we proposed that serotonergic projections forebrain also contribute response inhibition disease, based on preclinical animal human studies. We therefore examined whether selective serotonin reuptake inhibitor citalopram improves inhibition, terms both...
Through the combined use of (18)F-fallypride positron emission tomography and magnetic resonance imaging this study examined neural mechanisms underlying attentional deficits associated with attention deficit/hyperactivity disorder their potential reversal a single therapeutic dose methylphenidate. Sixteen adult patients 16 matched healthy control subjects were scanned tested on computerized sustained task after oral methylphenidate (0.5 mg/kg) placebo administration in within-subject,...
Dopaminergic drugs remain the mainstay of Parkinson's disease therapy but often fail to improve cognitive problems such as impulsivity. This may be due loss other neurotransmitters, including noradrenaline, which is linked impulsivity and response inhibition. We therefore examined effect selective noradrenaline reuptake inhibitor atomoxetine on inhibition in a stop-signal paradigm.
Parkinson's disease impairs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse control disorders affect ∼10% cases. Based on preclinical models we proposed that noradrenergic denervation contributes to impairment response inhibition, via changes in prefrontal cortex its subcortical connections. Previous work found selective noradrenaline reuptake inhibitor atomoxetine could improve gambling decisions reflection impulsivity. Here tested hypotheses...
Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These are impaired several psychiatric disorders, such as depression obsessive-compulsive disorder. We tested the effects of selective serotonin reuptake inhibitor escitalopram, using an acute clinically relevant dose (20 mg), 66 healthy male female volunteers a double-blind, placebo-controlled study. Participants performed test...
European medical students should have acquired adequate prescribing competencies before graduation, but it is not known whether this the case. In international multicenter study, we evaluated essential knowledge, skills, and attitudes in clinical pharmacology therapeutics (CPT) of final-year across Europe. a cross-sectional design, 26 schools from 17 countries were asked to administer standardized assessment questionnaire 50 students. Although there differences between schools, our results...
Cognitive decline is a common feature of Parkinson's disease, and many these cognitive deficits fail to respond dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy. Among these, the locus coeruleus-noradrenaline system has been extensively implicated in response inhibition deficits. Restoring noradrenaline levels using noradrenergic reuptake inhibitor atomoxetine can improve some patients with but there considerable...
Disinhibition is a cardinal feature of the behavioural variant frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often difficult to manage. The options for symptomatic treatments limited, but potential target therapy restoration serotonergic function, which both deficient in dementia closely associated with inhibitory control. Based on preclinical studies psychopharmacological interventions other disorders, we predicted inhibition would be right inferior...
Abstract Recent studies indicate that selective noradrenergic (atomoxetine) and serotonergic (citalopram) reuptake inhibitors may improve response inhibition in selected patients with Parkinson's disease, restoring behavioral performance brain activity. We reassessed the efficacy of these drugs a larger cohort developed predictive models to identify patient responders. used double‐blind randomized three‐way crossover design investigate stopping efficiency 34 idiopathic disease after 40 mg...
Apathy is a debilitating feature of many neuropsychiatric diseases, that typically described as reduction goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial. Degeneration locus coeruleus-noradrenaline system known to contribute motivational deficits, including apathy. In healthy people, noradrenaline has been implicated in signalling uncertainty expectations about environment. We proposed noradrenergic deficits by...
Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes neural regions remain unclear. The present study used pharmacological, event-related fMRI to test hypothesis that striatal dopamine is for manipulation of information Twenty healthy human subjects were scanned twice, once after placebo and sulpiride 400 mg, a selective D2 antagonist, while performing verbal memory task requiring levels manipulation. Whilst there...
The pathogenetic role of central serotonin transporters (SERT) in obsessive-compulsive disorder (OCD) has been investigated vivo by positron emission tomography (PET) or single-photon computed (SPECT) studies with inconsistent results. This might reflect methodological differences but possibly also the pathophysiological heterogeneity disorder, i.e. age at onset OCD. aim our study was to compare SERT availability patients OCD healthy controls (HC) taking into account type, other factors and...
Abstract Extracellular purines act as neuromodulators on transmitter release and may exert toxic effects at higher concentrations. In microdialysis studies, endogenous ATP facilitated the extracellular concentration of glutamate in nucleus accumbens (NAc) rats. Additionally, P2 receptors are involved astrogliosis vivo after a stab wound injury same region, suggesting that these receptors, preferentially metabotropic P2Y 1 receptor subtype, mediate also trophic responses. Two sets...