A5037711967- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Heavy Metal Exposure and Toxicity
- Cholinesterase and Neurodegenerative Diseases
- Treatment of Major Depression
- Biochemical effects in animals
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Trace Elements in Health
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Mind wandering and attention
- Psychedelics and Drug Studies
- Schizophrenia research and treatment
- Psychological Well-being and Life Satisfaction
- Alcoholism and Thiamine Deficiency
- Neonatal Health and Biochemistry
- Thyroid Disorders and Treatments
- Pesticide Exposure and Toxicity
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
University of Cambridge
2014-2025
Cambridgeshire and Peterborough NHS Foundation Trust
2020-2025
South London and Maudsley NHS Foundation Trust
2025
King's College London
2025
Maudsley Hospital
2025
National and Kapodistrian University of Athens
2008-2019
Wellcome Centre for Human Neuroimaging
2014-2017
University College London
2012-2017
Addenbrooke's Hospital
2016-2017
Laboratoire de Chimie
2014
Significance A common question in the social science of well-being asks, “How happy do you feel on a scale 0 to 10?” Responses are often related life circumstances, including wealth. By asking people about their feelings as they go lives, ongoing happiness and events have been linked, but neural mechanisms underlying this relationship unknown. To investigate it, we presented subjects with decision-making task involving monetary gains losses repeatedly asked them report momentary happiness....
The neuromodulator dopamine has a well established role in reporting appetitive prediction errors that are widely considered terms of learning. However, across wide variety contexts, both phasic and tonic aspects likely to exert more immediate effects have been less characterized. Of particular interest is dopamine9s influence on economic risk taking subjective well-being, quantity known be substantially affected by resulting from the outcomes risky choices. By boosting levels using levodopa...
<h3>Importance</h3> Major depressive disorder (MDD) is associated with deficits in representing reward prediction errors (RPEs), which are the difference between experienced and predicted reward. Reward underlie learning of values reinforcement models, represented by phasic dopamine release, known to affect momentary mood. <h3>Objective</h3> To combine functional neuroimaging, computational modeling, smartphone-based large-scale data collection test, absence learning-related concerns,...
Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These are impaired several psychiatric disorders, such as depression obsessive-compulsive disorder. We tested the effects of selective serotonin reuptake inhibitor escitalopram, using an acute clinically relevant dose (20 mg), 66 healthy male female volunteers a double-blind, placebo-controlled study. Participants performed test...
Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility important successful attainment of goals, as well social interactions, and frequently impaired in neuropsychiatric disorders, including obsessive-compulsive disorder. However, a unifying mechanistic framework accounting the role serotonin behavioral has remained elusive. Here, we demonstrate common effects manipulating function across two species (rats humans) on latent...
Objectives This survey assessed psychiatry residents'/early-career psychiatrists' attitudes towards the utility of therapeutic drug monitoring (TDM) antipsychotics.
Abstract Functional impairments in cognition are frequently thought to be a feature of individuals with depression or anxiety. However, documented both broad and inconsistent, little known about when they emerge, whether causes effects affective symptoms, specific cognitive systems implicated. Here, we show, the adolescent ABCD cohort (N = 11,876), that attention dysregulation is robust factor underlying wide-ranging task seen adolescents moderate severe anxiety low mood. We stratified high...
Abstract: Manganese (Mn) is an essential metalloenzyme component that in high doses can exert serious oxidative and neurotoxic effects. The aim of this study was to investigate the potential effect antioxidant l ‐cysteine (Cys, 7 mg/kg) on adult rat brain total status (TAS) activities acetylcholinesterase (AChE), Na + ,K ‐ATPase Mg 2+ induced by short‐term Mn administration (as chloride, 50 mg/kg). Twenty‐eight male Wistar rats were divided into four groups: A (saline‐treated control), B...
Atomoxetine and escitalopram are potent selective drugs approved for noradrenergic or serotonergic modulation of neuronal networks in attention-deficit hyperactivity disorder (ADHD) depression, respectively. High-performance liquid chromatography (HPLC) methods still play an important role the therapeutic drug monitoring (TDM) psychopharmacological drugs, coupled with tandem mass spectrometry gold standard quantification biological matrices, but not available everywhere. The aim this work...
Abstract Hypothyroidism is known to exert significant structural and functional changes the developing central nervous system, can lead establishment of serious mental retardation neurological problems. The aim present study was shed more light on effects gestational and/or lactational maternal exposure propylthiouracil‐induced experimental hypothyroidism crucial brain enzyme activities Wistar rat offspring, at two time‐points their lives: birth (day‐1) 21 days age (end lactation). Under all...
Abstract Background Risk is an essential trait of most daily decisions. Our behaviour when faced with risks involves evaluation many factors including the outcome probabilities, valence (gains or losses) and past experiences. Several psychiatric disorders belonging to distinct diagnostic categories, pathological gambling addiction, show risk-taking implicate abnormal dopaminergic, opioidergic serotonergic neurotransmission. In this study, we adopted a transdiagnostic approach delineate...
Abstract Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility important both successful attainment of goals, as well social interactions, and frequently impaired in neuropsychiatric disorders, including obsessive-compulsive disorder (OCD). However, a unifying mechanistic framework accounting the role serotonin behavioral has remained elusive. Here, we demonstrate common effects manipulating function across two species (rats...
Neurodevelopment is known to be particularly susceptible thyroid hormone insufficiency and can result in extensive structural functional deficits within the central nervous system (CNS), subsequently leading establishment of cognitive impairment neuropsychiatric symptomatology. The current study evaluated effects gestational and/or lactational maternal exposure propylthiouracil (PTU)-induced hypothyroidism (as a suggestive multilevel experimental approach hypothyroidism-induced changes that...