A5046757283- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- Behavioral and Psychological Studies
- Psychological Treatments and Assessments
- Neurological Disorders and Treatments
- Photoreceptor and optogenetics research
- Mind wandering and attention
- Sleep and related disorders
- Free Will and Agency
- Nicotinic Acetylcholine Receptors Study
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
Pusan National University
2020-2025
University of Cambridge
2014-2023
Convergence
2023
Pusan National University Yangsan Hospital
2023
Ulsan National Institute of Science and Technology
2017-2019
Korea Advanced Institute of Science and Technology
2007-2017
Addenbrooke's Hospital
2014-2017
Athinoula A. Martinos Center for Biomedical Imaging
2011-2017
Massachusetts General Hospital
2012-2017
Cambridgeshire and Peterborough NHS Foundation Trust
2015-2017
Familial hemiplegic migraine type 1, a monogenic variant with aura, is linked to gain-of-function mutations in the CACNA1A gene encoding Ca V 2.1 channels. The S218L mutation causes severe channel dysfunction, and paroxysmal attacks can be accompanied by seizures, coma, hemiplegia; patients expressing R192Q exhibit hemiplegia only. knock-in mice or are highly susceptible cortical spreading depression, electrophysiological surrogate for develop prolonged motor deficits after depression....
Our decisions are based on parallel and competing systems of goal-directed habitual learning, which can be impaired in pathological behaviours. Here we focus the influence motivation compare reward loss outcomes subjects with obsessive-compulsive disorder (OCD) model-based model-free behaviours using two-step task. We further investigate relationship acquisition learning a one-step probabilistic Forty-eight OCD 96 healthy volunteers were tested 30 53 version Thirty-six 72 also reversal...
Abstract Suicide attempters have been found to be impaired in decision-making; however, their specific biases evaluating uncertain outcomes remain unclear. Here we tested the hypothesis that suicidal behavior is associated with heightened aversion risk and loss, which might produce negative predictions about future events. Forty-five depressed patients a suicide attempt history, 47 nonsuicidal patients, 75 healthy controls participated monetary decision-making tasks assessing loss aversion....
Functional neurological disorders (FNDs), also known as conversion disorder, are unexplained symptoms unrelated to a cause. The disorder is common, yet poorly understood. experienced involuntary but have similarities voluntary processes. Here we studied intention awareness in FND.A total of 26 FND patients and 25 healthy volunteers participated this functional magnetic resonance study using Libet's clock.FND characterized by delayed the move relative movement itself. reporting was more...
BackgroundWhy do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as predictor for development addiction. Here, mapped intrinsic neural correlates waiting and dissociated it from stopping, both fundamental mechanisms behavioral control.MethodsWe used recently developed translational task to assess premature responding response inhibition using stop signal task. We in 55 healthy volunteers novel multi-echo resting-state functional magnetic resonance imaging...
We focus on exploratory decisions across disorders of compulsivity, a potential dimensional construct for the classification mental disorders. Behaviors associated with pathological use alcohol or food, in (AUD) binge-eating disorder (BED), suggest disturbance explore–exploit decision-making, whereby strategic an attempt to improve long-term outcomes may diminish favor more repetitive exploitatory choices. compare exploration vs exploitation natural (obesity and without BED) drug rewards...
The efficient organization and communication of brain networks underlie cognitive processing their disruption can lead to pathological behaviours. Few studies have focused on whole-brain in obesity binge eating disorder (BED). Here we used multi-echo resting-state functional magnetic resonance imaging (rsfMRI) along with a data-driven graph theory approach assess network characteristics BED.Multi-echo rsfMRI scans were collected from 40 obese subjects (including 20 BED patients) healthy...
Binge consumption of alcohol is a major societal problem associated with important cognitive, physiological and neurotoxic consequences. Converging evidence highlights the need to assess binge drinking (BD) its effects on developing brain while taking into account gender differences. Here, we compared volumetric differences between genders in college-aged drinkers healthy volunteers.
Abstract Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in alcohol and opiate addiction, but its efficacy the mechanisms underpinning clinical usefulness are not well characterized. In current study, we examined effects of 50‐mg naltrexone compared with placebo on neural network changes associated substance dependence 21 36 poly‐drug‐dependent individuals healthy volunteers. Graph theoretic network‐based statistical analysis resting‐state...
Abstract Our daily decisions are governed by the arbitration between goal-directed and habitual strategies. However, neurochemical basis of this is unclear. We assessed contribution dopaminergic, serotonergic, opioidergic systems to balance across reward loss domains. Thirty-nine participants (17 healthy controls, 15 patients with pathological gambling, 7 binge eating disorder) underwent positron emission tomography (PET) imaging [ 18 F]FDOPA, 11 C]MADAM C]carfentanil assess presynaptic...
The capacity to flexibly respond contextual changes is crucial adapting a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. subthalamic nucleus (STN) mediates the switch from automatic controlled processing slow, break stop behaviour when necessary. Rodent STN lesions inactivation are linked perseveration repetitive, compulsive responding. However, there few studies examining role latent...
Abstract Binge drinking represents a public health issue and is known risk factor in the development of alcohol use disorders. Previous studies have shown behavioural as well neuroanatomical alterations associated with binge drinking. Here, we address question automaticity or involuntary nature behaviour by assessing goal‐directed intentionality. In this study, used computational two‐step task, designed to discern between model‐based/goal‐directed model‐free/habitual behaviours, classic...
Functional neurological disorder (FND) is an elusive characterized by unexplained symptoms alongside aberrant cognitive processing and negative affect, often associated with amygdala reactivity.We examined the effect of conditioning on function reactivity in 25 FND patients 20 healthy volunteers (HV). Participants were first conditioned to stimuli paired affective or neutral (CS +/CS -) information. During functional MRI, subjects then performed instrumental associative learning task avoid...
Although poor decision-making ultimately impairs quality of life in depression, few studies describe the clinical characteristics patients suffering from dysfunctional decision-making. This study aims to delineate effect childhood trauma and other personality factors on risk-aversive loss-aversive patterns with depression.A total 50 depressive completed surveys for measurement sociodemographic factors, loads characteristics, including anxiety, strategies emotion regulation. Risk aversion...
Smoking is a severe addictive health risk behavior and notorious for the high likelihood of relapse after attempted cessation. Such an pattern in smoking has been associated with neurobiological changes brain. However, little known whether neural chronic persist long period successful abstinence. To address this question, we examined resting state EEG (rsEEG) smokers who have 20 years or more, past-smokers successfully abstaining never-smokers. Both current-smokers showed significantly...
The ability to wait and weigh evidence is critical behavioral regulation. These behaviors are known as waiting reflection impulsivity. In Study 1, we examined the effects of methylphenidate, a dopamine norepinephrine reuptake inhibitor, on impulsivity in healthy young individuals. study 2, assessed role learning from feedback disorders addiction. We used recently developed 4-Choice Serial Reaction Time task Beads task. Twenty-eight volunteers were tested twice randomized, double-blind,...
Impulsivity and reward expectancy are commonly interrelated. Waiting impulsivity, measured using the rodent 5-Choice Serial Reaction Time task, predicts compulsive cocaine seeking sign (or cue) tracking. Here, we assess human waiting impulsivity a novel translational 4-Choice relationship with cues.Healthy volunteers (n=29) performed monetary incentive delay task as functional MRI study where subjects observe cue predicting (cue) wait to respond for high (£5), low (£1), or no reward. was...
Abstract Tissue clearing has gained attention as a pioneering research tool for imaging of large tissue samples. This technique improves light transmission by reducing scattering within tissues, either removing lipids or replacing water with high refractive index solution. Although various techniques have been developed, quantitative assessments on efficacy depending properties are rare. In this study, we developed the mapping regional using mean free path in optical coherence tomography...
Background: The mesial prefrontal cortex, cingulate and the ventral striatum are key nodes of human fronto-striatal circuit involved in decision-making executive function pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting cortex (MPFC) influences resting state functional connectivity. Methods: In Study 1, examined connectivity using multi-echo independent components analysis 154 healthy subjects to characterize default...