A5043577990- Musculoskeletal pain and rehabilitation
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spine and Intervertebral Disc Pathology
- Genetic factors in colorectal cancer
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Health Systems, Economic Evaluations, Quality of Life
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Geographies of human-animal interactions
- RNA modifications and cancer
- Opioid Use Disorder Treatment
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury Research
- Pain Management and Placebo Effect
- Anesthesia and Pain Management
- Wnt/β-catenin signaling in development and cancer
- RNA Interference and Gene Delivery
Hormel (United States)
2015-2025
University of Minnesota
2015-2025
University of Minnesota Medical Center
2020-2024
Masonic Cancer Center
2020-2024
Therapeutics Clinical Research
2023
University of Washington
2008-2021
Sydney Children’s Hospitals Network
2021
The University of Sydney
2021
Seattle University
1999-2018
University of Utah
2013-2015
Turk, Dennis C.a,*; Dworkin, Robert H.b; Burke, Laurie B.c; Gershon, Richardd; Rothman, Margarete; Scott, Janec; Allen, R.f,1; Atkinson, Hampton J.g; Chandler, Julieh; Cleeland, Charlesi; Cowan, Pennyj; Dimitrova, Rozalinak; Dionne, Raymondl,2; Farrar, John T.m; Haythornthwaite, Jennifer A.n; Hertz, Sharonc; Jadad, Alejandro R.o; Jensen, Mark P.a; Kellstein, Davidp,3; Kerns, D.q,r; Manning, Donald C.s; Martin, Susant; Max, Mitchell B.l,2; McDermott, Michael P.b; McGrath, Patricku; Moulin,...
Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT signaling in human melanoma metastases led us to evaluate effect activated AKT1 expression non-metastatic BRAF(V600E)/Cdkn2a(Null) mouse melanomas vivo. Expression resulted highly metastatic with lung and brain 67% 17% our mice, respectively. Silencing PTEN cooperated AKT1, resulting decreased tumor latency development nearly 80% tumor-bearing mice. These data demonstrate that activation...
Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1R132H gliomagenesis has been proposed, but functional validation vivo not demonstrated. In this study, we assessed of development context clinically relevant cooperating genetic alterations vitro vivo. Immortal astrocytes expressing exhibited elevated (R)-2-hydroxyglutarate levels, reduced NADPH, increased proliferation, anchorage-independent...
Abstract Objective People with fibromyalgia (FM) report a number of physical, cognitive, and psychological symptoms. The purpose the current study was to determine whether people FM differed based on type severity symptoms, if so, subgroups differ respect health care utilization, functional ability, work status. Methods Symptom, work, physical data were available for 2,182 female responders an Internet survey. Factor analysis conducted cognitive/psychological resulting factor scores utilized...
A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin ( smmhc / myh11 ) underlying the zebrafish meltdown mlt phenotype. The develops intestinal abnormalities reminiscent of human Peutz–Jeghers syndrome (PJS) and juvenile polyposis (JP). To examine role MYH11 neoplasia, we searched for mutations patients with colorectal cancer (CRC), PJS JP. We found somatic protein-elongating frameshift 55% CRCs displaying microsatellite instability one individual...
Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase activity, leading to global reduction and redistribution repressive H3 lysine 27 tri-methylation (H3K27me3). This epigenomic rewiring thought promote gliomagenesis, but precise role K27M in gene regulation tumorigenesis remains incompletely understood. We established isogenic DMG patient-derived cell lines using CRISPR-Cas9...
The fear avoidance model (FAM) postulates that of pain or reinjury is a risk factor for persistent and disability, because it leads to the physical activity. Research on FAM has not yielded consistent results, which may be attributed itself, but could also product way movement assessed. Studies have measured using verbal scales consisting items are often vague only an indirect relationship with fear. This study reports development Pictorial Fear Activity Scale-Cervical (PFActS-C). instrument...
Patients with Peutz-Jeghers syndrome (PJS) are affected by hamartomatous intestinal polyposis and increased risk of cancers in multiple organs caused germline mutations the tumour suppressor gene LKB1. Murine models that recapitulate aspects PJS have been created. Here we examine therapeutic effect rapamycin, a macrolide anti-tumourigenic anti-angiogenic properties, reducing incidence large cohort Lkb1(+/-) mice. To study influence early intervention, animals were dosed rapamycin from age 8...
Study Design. The study measured the reliability of passive straight leg raise (SLR) test and lumbar range motion (LROM) tests as continuous variables embedded within a comprehensive physical examination. Objectives. To determine SLR LROM scores when they are with Cybex electronic inclinometer (Lumex, Inc., New York, NY) Summary Background Data. Good published empirical exists for measurements taken in isolation from other examination procedures. Reliability measurement has not been...
Abstract Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli ( APC ), has a major role in colorectal cancer (CRC). Most components have not been assessed for sporadic CRC. We analyzed AXIN2 , CK1 α, DKK1 GSK‐3 β, SOX17, LRP6 and PPP2R1B β‐ catenin collection CRCs n = 47) CRC cell lines (CLs; 26). The set was enriched microsatellite unstable cancers (MSI+, 30%, 14/47). Somatic found or β; but heterozygous frame‐shift mutations, an in‐frame...
Objective. The American College of Rheumatology (ACR) tender point (TP) criterion is used in diagnosing fibromyalgia syndrome (FM). There has been little research investigating patterns positive TP. We investigated response TP a sample patients with FM. Methods. Manual survey data were available on 1433 Factor analysis was conducted ACR and control (CON) points. scores cluster analyzed to identify subgroups based scores. Subgroups compared demographic psychosocial variables. Results....
Fear and avoidance of activity may play a role in fostering disability whiplash-associated disorders (WAD). This study examined the fear after WAD assessed effectiveness 3 treatments targeting fear. People still symptomatic from grade I-II injuries approximately 3months previously (n=191) completed questionnaires (eg, Neck Disability Index [NDI]) were randomized to 1 treatments: (1) informational booklet (IB) describing importance resuming activities, (2) IB+didactic discussions (DD) with...
The purpose of this descriptive, correlational study was to investigate the relationship between continuing education and job satisfaction among RNs licensed practical nurses (LPNs) employed in long-term care facilities.Herzberg's Motivational-Hygiene Theory used as a framework guide design study. Professional Educational Activities Scale McCloskey/Mueller Satisfaction were completed by 110 facilities.No difference found type employment status (full-time versus part-time) on level...