A5053260972- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Mechanisms and Treatments
- Opioid Use Disorder Treatment
- Pain Management and Opioid Use
- Psoriasis: Treatment and Pathogenesis
- Sexual function and dysfunction studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric Pain Management Techniques
- Hormonal and reproductive studies
- Health Systems, Economic Evaluations, Quality of Life
- Delphi Technique in Research
- Spondyloarthritis Studies and Treatments
- Asthma and respiratory diseases
- Sexuality, Behavior, and Technology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Meta-analysis and systematic reviews
- Diverse Approaches in Healthcare and Education Studies
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical Practices and Patient Outcomes
- Respiratory Support and Mechanisms
- Sexual Differentiation and Disorders
- Pregnancy-related medical research
- Spine and Intervertebral Disc Pathology
Boehringer Ingelheim (Canada)
2023
Boehringer Ingelheim (China)
2022
Ithaka Harbors
2014-2021
Pfizer (United States)
2021
Duke University
2021
University of Rochester Medical Center
2021
Harvard University
2020
Boehringer Ingelheim (United States)
2019
GlaxoSmithKline (United Kingdom)
2017
University College Hospital
2016
Little is known of the potential long-term gait alterations that occur after an anterior cruciate ligament (ACL) reconstruction. In particular, variables, such as impact loading, which have been previously associated with joint deterioration, not studied in walking and running ACL The purpose this study was to define forces, loading rates, accompanying sagittal plane kinematic kinetic mechanics at time between ACL-reconstructed group a healthy control group.Forty females (20 reconstruction...
Abstract Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the use of analgesic treatments in practice. In this article, we report on an Initiative Methods, Measurement, and Pain Assessment Clinical Trials (IMMPACT) consensus meeting organized by Analgesic, Anesthetic, Addiction Trial Translations, Innovations, Opportunities, Networks, purpose which was recommend approaches that facilitate interpretation RCTs. We review issues consider when drawing...
Abstract Objective People with fibromyalgia (FM) report a number of physical, cognitive, and psychological symptoms. The purpose the current study was to determine whether people FM differed based on type severity symptoms, if so, subgroups differ respect health care utilization, functional ability, work status. Methods Symptom, work, physical data were available for 2,182 female responders an Internet survey. Factor analysis conducted cognitive/psychological resulting factor scores utilized...
The St George's Respiratory Questionnaire (SGRQ) has been used to measure health-related quality of life (HRQoL) in patients with idiopathic pulmonary fibrosis (IPF). This analysis evaluated the psychometric properties SGRQ using data from 428 IPF who participated a 12-month, randomised, placebo-controlled phase II trial nintedanib. Internal consistency (Cronbach's α) was 0.91 for total and >0.70 domain scores. Test–retest reliability (intraclass correlation coefficients) 0.77, 0.69 0.66...
Introduction We evaluated the psychometric properties of St George’s Respiratory Questionnaire (SGRQ) in patients with idiopathic pulmonary fibrosis (IPF) using data from two INPULSIS trials. Methods Data 1061 treated nintedanib or placebo were pooled. Internal consistency, test–retest reliability, construct validity, known-groups responsiveness and responder thresholds examined. Results Cronbach’s α was 0.93 for SGRQ total score >0.75 domain scores. In stable disease based on change...
The clinical course of Crohn's disease (CD) and the effect its treatment are monitored through patient-reported signs symptoms (S&S), endoscopic evidence inflammation. Disease Patient-reported Outcomes Signs Symptoms (CD-PRO/SS) measure was developed to standardize quantification gastrointestinal S&S CD direct report from patient ratings. CD-PRO/SS based on data concept elicitation (focus groups, interviews; n = 29), then refined cognitive interviews patients (n 20). Measurement properties,...
To evaluate the measurement properties (e.g., content validity, reliability, and ability to detect change) of Functional Assessment Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). One-on-one semi-structured qualitative interviews adult PsA evaluated validity FACIT-Fatigue. Quantitative were using data from phase III tofacitinib randomized controlled trials (RCTs) PsA: OPAL Broaden (NCT01877668) Beyond (NCT01882439). Of 12 included study, 2...
In this phase of the ongoing What Matters Most study series, designed to evaluate concepts that are meaningful people affected by Alzheimer's disease (AD), we quantified importance symptoms, impacts, and outcomes AD at risk for or with care partners AD.We administered a web-based survey individuals (Group 1: unimpaired cognition evidence pathology; Group 2: factors subjective cognitive complaints/mild impairment; 3: mild AD) moderate 4) severe 5). Respondents rated 42 on scale ranging from 1...
The anterior cingulate cortex (ACC) is involved in the affective and motivational aspect of pain perception. Behavioral studies show a decreased avoidance behavior to noxious stimuli without change mechanical threshold after stimulation ACC. However, as part neural circuitry behavioral reflexes, there no evidence showing that ACC alters dorsal horn neuronal responses. We hypothesize has two phases: short-term phase which elicits antinociception long-term follows response input. To begin...
Opioid-induced constipation (OIC), a common side effect of opioid treatment for chronic pain, affects patient health-related quality life (HRQL) and may prompt some patients to lower the dose or alter adherence their medication, compromising pain relief. Although health care providers (HCPs) are aware potential OIC, not inform HCPs OIC symptoms, initiate conversation regarding if patients' is controlled. Patients often try address symptoms on own by using natural approaches over-the-counter...
Insight into the relationship between concepts that matter to people affected by Alzheimer's disease (AD) and clinical outcome assessments (COAs) commonly used in AD studies is limited. Phases 1 2 of What Matters Most (WMM) study series identified quantitatively confirmed 42 treatment-related outcomes are important AD.We compared WMM rated as "very important" or higher items included COAs studies.Twenty designed assess signs, symptoms, impacts across spectrum were selected for review. Among...
Objective. The American College of Rheumatology (ACR) tender point (TP) criterion is used in diagnosing fibromyalgia syndrome (FM). There has been little research investigating patterns positive TP. We investigated response TP a sample patients with FM. Methods. Manual survey data were available on 1433 Factor analysis was conducted ACR and control (CON) points. scores cluster analyzed to identify subgroups based scores. Subgroups compared demographic psychosocial variables. Results....
Conditioned pain modulation (CPM) is a phenomenon that may be tested with dynamic quantitative sensory test assesses the inhibitory aspect of this modulatory network. Although CPM has been adopted as clinical assessment tool in recent years, stability measure not determined over long time intervals. The question crucial to our understanding processing, and critical for use test. primary objective study was evaluate paradigm healthy women. secondary determine potential influence menstrual...
Fear and avoidance of activity may play a role in fostering disability whiplash-associated disorders (WAD). This study examined the fear after WAD assessed effectiveness 3 treatments targeting fear. People still symptomatic from grade I-II injuries approximately 3months previously (n=191) completed questionnaires (eg, Neck Disability Index [NDI]) were randomized to 1 treatments: (1) informational booklet (IB) describing importance resuming activities, (2) IB+didactic discussions (DD) with...
Abstract Objective The SENSCIS® trial demonstrated a significant reduction of lung function decline in patients with SSc-associated interstitial disease (SSc-ILD) treated nintedanib, but no effect on health-related quality life (HRQoL). To assess whether SSc/SSc-ILD severity and large changes correlate HRQoL, post-hoc analysis SENSCIS®, aggregating treatment arms, was undertaken. Methods Patient-reported outcome (PRO) measures [St. George’s Respiratory Questionnaire (SGRQ), Functional...