Abstract Background It is well established that the different antipsychotics used for schizophrenia symptoms differ substantially in their side effects. However, relatively little known about impact of these effects on functioning from patient’s perspective. We aimed to understand how key second-generation and quality life (QoL) patients with schizophrenia. Methods This a cross-sectional, web-based survey patient-reported effect burden antipsychotic drugs adults The was deployed United...

Abstract Background The Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance v1.0 item bank (27 items) measures sleep disturbances. Rather than the full bank, an 8-item short form (PROMIS SD SF 8b) or computerized adaptive testing (CAT) can be used. This study compares performance of PROMIS 8b with two CAT algorithms in postmenopausal women. Methods is a secondary analysis data collected for original psychometric sub-sample women aged ≥55. A graded response...

Abstract Background While many publications have outlined good practice recommendations for translation and electronic implementation of clinical outcome assessments (COAs), they are often treated as independent processes. The scientific literature currently lacks recommended guidelines on the process concurrent translation, cultural adaptation COAs research. In response to this need, ISOQOL Translation Cultural Adaptation Special Interest Group (TCA-SIG) sought identify actionable steps...

To evaluate the measurement properties (e.g., content validity, reliability, and ability to detect change) of Functional Assessment Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). One-on-one semi-structured qualitative interviews adult PsA evaluated validity FACIT-Fatigue. Quantitative were using data from phase III tofacitinib randomized controlled trials (RCTs) PsA: OPAL Broaden (NCT01877668) Beyond (NCT01882439). Of 12 included study, 2...

Abstract Purpose/Background RE-KINECT (NCT03062033) was designed to assess the presence and impact of possible tardive dyskinesia (TD) in antipsychotic-treated outpatients. Methods/Procedures The study included adults with 3 or more months lifetime antipsychotic exposure 1 psychiatric disorder. Based on clinician observation assessment, patients were assigned cohort (without involuntary movements non-TD movements) 2 (with confirmed by as TD). Baseline assessments following: patient...

To assess the measurement properties of Migraine-Specific Quality Life Questionnaire version 2.1 (MSQv2.1) electronic patient-reported outcome (ePRO) Role Function-Restrictive (RFR) domain to evaluate functional impact migraine in patients with episodic (EM) or chronic (CM) enrolled clinical trials.

A concept elicitation, cognitive debriefing, and usability study was undertaken to: 1) ascertain the migraine experience with a particular focus on impact roles daily functioning; 2) determine comprehensiveness comprehensibility of Migraine-Specific Quality Life Questionnaire version 2.1 electronic patient-reported outcome Role Function-Restrictive (MSQ v2.1 ePRO RFR) domain items, appropriateness understanding recall period, response options, instructions; 3) assess an tablet device. Eleven...

Abstract Background Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with antipsychotic use. Data from RE-KINECT, real-world study of antipsychotic-treated outpatients, were analyzed to assess the effects possible TD on patient health social functioning. Methods Analyses conducted in Cohort 1 (patients no abnormal involuntary movements) 2 per clinician judgment). Assessments included: EuroQoL’s EQ-5D-5L utility (health); Sheehan Disability Scale...

Purpose – Without some flexibility, replications of manualised evidence‐based programmes (EBP) may not achieve predictable outcomes due to differences in cultural priorities. In this case study, Families and Schools Together (FAST) was co‐produced with elders from a community Hmong political refugees the US Mid‐West. The paper aims describe evaluate process culturally adapting implementing universal parenting programme.

To evaluate the measurement properties (e.g. content validity, reliability and ability to detect change) of Functional Assessment Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). One-on-one semi-structured qualitative interviews adult PsA evaluated validity FACIT-Fatigue. Quantitative were using data from phase III tofacitinib randomized controlled trials (RCTs) PsA: OPAL Broaden (NCT01877668) Beyond (NCT01882439). Of 12 included study, 2 (17%)...

The Kingdom of Saudi Arabia (KSA) has the second highest prevalence type 2 diabetes mellitus (T2DM) in Middle East. There is a paucity research on experiences and treatment preferences patients with T2DM KSA. This study explored patients' health-related quality life, eating habits, during Ramadan, preference between two glucagon-like peptide-1 receptor agonist (GLP-1 RA) devices.A cross-sectional, observational was conducted three cities Participants completed sociodemographic clinical...

RE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included questionnaire to assess the effects patients' abnormal involuntary movements on caregivers.To capture experiences caregivers who assisted individuals with that were confirmed by clinicians as being consistent TD.Qualified (nonpaid) invited complete following: caregivers' sociodemographic characteristics, their perceptions about impact and these themselves...

Abstract Objective Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with antipsychotic treatment. RE KINECT (NCT03062033), real-world study of outpatients prescribed antipsychotics, was designed to identify the presence possible TD and characterize impact involuntary movements on functioning quality life. Data from RE-KINECT were used compare in patients schizophrenia/schizoaffective [SZD] versus mood/other psychiatric disorders [Mood]. Methods Adults ≥3months lifetime...

<b>Background:</b> Mepolizumab (Nucala^®) is licensed for severe eosinophilic asthma (SEA). Autoinjector (AI) and prefilled syringe (PFS) have been developed to enable in-clinic at-home self-administration which may improve patient treatment experience. <b>Objectives:</b> To summarise qualitative interview responses understand the PTE with mepolizumab AI PFS. <b>Methods:</b> Two studies (NCT03099096 &amp; NCT03021304) in SEA patients evaluated real-word use of (100mg SC)...

Abstract: Study Objective: Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with prolonged antipsychotic use. RE KINECT, real-world screening study of antipsychotic-treated outpatients, included patients movements that were clinician-confirmed as possible TD (Cohort 2) no involuntary 1). Baseline data from the patient rated EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L) Sheehan Disability Scale (SDS) analyzed to evaluate health related...

Abstract Background Tardive dyskinesia (TD) is associated with prolonged exposure to dopamine receptor blockers including antipsychotics. This registry describes the prevalence and impact of involuntary movements (possible TD) in a real-world population patients taking Methods RE-KINECT (NCT03062033) aims enroll 1,000 from 70 US psychiatric practices. Adults ≥3 months lifetime antipsychotic(s) ≥1 disorder are eligible for two-tier screening: informal observation, then clinician observation...

Many studies have shown that certain ethnic minorities in the UK are more likely to be diagnosed with schizophrenia than British-born citizens. The most prominent research has focused on African-Caribbean and British white incidence rates while disregarding other immigrant groups. US currently marked by a constant influx of international migration thus cross-cultural differences manifestations must seen as crucial inescapable step for adhering culturally sensitive competent psychiatric...

In patients with schizophrenia, antipsychotic medications, including second-generation antipsychotics, may cause many side-effects (SE) often leading to treatment discontinuation, and possible relapse as a consequence. The impact of treatments on patient-centered outcomes such health-related quality life (HRQOL) is less well understood. Even understood the side effects daily functioning HRQOL. Therefore, study’s primary goal was gain deeper understanding impacts SEs second generation...