A5062054172- Asthma and respiratory diseases
- Osteoarthritis Treatment and Mechanisms
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Lymphoma Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Inflammatory mediators and NSAID effects
- Biosimilars and Bioanalytical Methods
- Complementary and Alternative Medicine Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- CAR-T cell therapy research
- Statistical Methods in Clinical Trials
- Medicinal plant effects and applications
- Advanced Causal Inference Techniques
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Head and Neck Surgical Oncology
- Inflammatory Bowel Disease
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nasal Surgery and Airway Studies
- Proteoglycans and glycosaminoglycans research
GlaxoSmithKline (United States)
2018-2024
Genmab (United States)
2023-2024
University of Alabama at Birmingham
2002-2018
Diagnostics for the Real World (United States)
2017
University of Massachusetts Chan Medical School
2015
Virginia Commonwealth University
2011-2015
Virginia Commonwealth University Medical Center
2013
Children's Hospital of Richmond at VCU
2013
May Institute
2013
Capital Medical University
2008-2010
Introduction Efficacy of mepolizumab, an anti-interleukin-5 monoclonal antibody, was demonstrated in randomised controlled trials; data on its real-world impact routine clinical practice are starting to emerge. We assessed the effectiveness and safety mepolizumab prescribed for patients real world. Methods REALITI-A is a global, prospective, observational cohort study, collecting from healthcare visits with asthma. Patients newly severe asthma 12 months relevant medical history...
Objective The effect of short‐term and long‐term use nonsteroidal antiinflammatory drugs (NSAIDs) on structural change is equivocal. aim this study was to estimate the extent which short‐ prescription NSAIDs relieve symptoms delay progression among patients with radiographically confirmed osteoarthritis (OA) knee. Methods We applied a new‐user design participants OA not reporting NSAID at time enrollment in Osteoarthritis Initiative. Participants were evaluated for changes Western Ontario...
The SYNAPSE study (NCT03085797) demonstrated that mepolizumab decreased nasal polyp (NP) size and obstruction in patients with chronic rhinosinusitis NP (CRSwNP).SYNAPSE, a randomized, double-blind study, included recurrent, refractory, severe CRSwNP, eligible for repeated surgery despite receiving standard of care (SoC). Patients received 4-weekly 100 mg or placebo subcutaneously plus SoC 52 weeks. This post hoc analysis further characterized treatment responses association patient...
The purpose of this study was to estimate the effectiveness combination glucosamine and chondroitin in relieving knee symptoms slowing disease progression among patients with osteoarthritis (OA). 4-year followup data from Osteoarthritis Initiative set were analyzed. We used a "new-user" design, for which only participants who not using glucosamine/chondroitin at baseline included analyses (n = 1,625). Cumulative exposure calculated as number visits when reported use glucosamine/chondroitin....
Background: Knee osteoarthritis (OA) increases healthcare use and cost. Women have higher pain lower quality of life measures compared to men even after accounting for differences in age, body mass index (BMI), radiographic OA severity. Our objective was describe gender-specific correlates complementary alternative medicine (CAM) among persons with radiographically confirmed knee OA. Methods: Using data from the Osteoarthritis Initiative, 2,679 women tibiofemoral at least one were...
A limited number of small studies have examined the vitamin D status pediatric oncology patients, and results indicate an increased prevalence hypovitaminosis. We conducted a cross-sectional study with primary aim describing our cancer patients any associations demographic characteristics. Our secondary was to compare this that healthy population. collected data on children seen in clinic determined overall then compared populations described literature. The hypovitaminosis population 72%....
Glycogen synthase kinase-3 (GSK3) is a constitutively active protein kinase that involved in neuronal regulation and potential pharmacological target of neurological disorders. We found previously GSK3β selectively interacts with 5-hydroxytryptamine-1B receptors (5-HT1BR) have important functions serotonin neurotransmission behavior. In this study, we provide new information supporting the importance 5-HT1BR-regulated signaling, physiological function, behaviors. Using molecular,...
Background: This retrospective cohort study aimed to describe and quantify healthcare resource utilization costs for patients with ulcerative colitis (UC) Crohn’s disease (CD) following initiation of biologic therapy. Methods: Resource were analyzed at baseline 1- 2-years after initiating a biologic. Data extracted from US administrative health insurance claims database adults ≥18 years. Eligible continuously enrolled in plan medical pharmacy benefits ≥12 months prior to, 12 (primary...
To investigate the changes in asthma exacerbation, as well oral corticosteroid (OCS) use, exacerbation-related healthcare resource utilization (HRU), and costs before after mepolizumab treatment initiation patients with severe who started a real-world clinical setting Japan. A retrospective, observational, self-controlled study was conducted Japan using hospital-based administrative claims database. Patients were diagnosed new users of included study. The primary outcome incidence rate any...
To analyse the cost-effectiveness of MEP with standard care (SoC) versus other anti-IL-5 therapies approved for treatment severe eosinophilic asthma (SEA) patients, within Spanish National Health System (NHS) perspective.A Markov model a 4-week cycle length was used to compare BEN and RES as added SoC in management SEA, terms cost per QALY gained incremental ratio (ICER). Costs (€2019) were obtained from public sources, while utilities transition probabilities retrieved literature, e.g....
The extent to which racial differences exist in use of treatments for osteoarthritis (OA) is debatable. purpose this study was describe the between African Americans (AA) and Caucasian (CA) using treatment approaches manage symptoms among individuals with radiographic-confirmed knee OA. A cross-sectional conducted. Using data from Osteoarthritis Initiative, we identified 508 AA 2,075 CA radiographic tibiofemoral OA at least one knee. Trained interviewers asked questions relating current...
To characterise the real-world burden of chronic rhinosinusitis with nasal polyps (CRSwNP) in UK, stratified by number surgeries.Retrospective cohort study.UK Clinical Practice Research Datalink Aurum database Hospital Episodes Statistics linkage (2007-2019).Adults ≥18 years age a first NP diagnosis (index) and 365 days baseline ≥180 follow-up data. Follow-up continued until disenrollment, death or end data collection.Primary: primary care physician prescribed CRSwNP-related treatments,...
Obesity is associated with knee pain and an independent predictor of incident osteoarthritis (OA); increased movement often leads patients to adopt sedentary lifestyles avoid pain. Detailed descriptions management strategies by body mass index (BMI) level among OA are lacking. The objectives were describe complementary alternative medicine (CAM) conventional medication use BMI identify correlates CAM level. Using Osteoarthritis Initiative baseline data, 2,675 radiographic tibiofemoral in at...
Mepolizumab improves quality of life and reduces activity impairments in patients with CRSwNP.