A5010362958- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Bladder and Urothelial Cancer Treatments
- Diabetes Treatment and Management
- Cleft Lip and Palate Research
- Inflammatory Bowel Disease
- Microscopic Colitis
- DNA Repair Mechanisms
- Respiratory and Cough-Related Research
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Acute Lymphoblastic Leukemia research
- Muscle Physiology and Disorders
GlaxoSmithKline (United Kingdom)
2016-2021
Age UK
2021
Health Economics and Outcomes Research (United Kingdom)
2020
Truven Health Analytics (United States)
2015-2016
Fred Hutch Cancer Center
2010-2014
Cancer Research Center
2013-2014
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2013-2014
University of Washington
2009-2013
Cancer Genetics (United States)
2013
National Human Genome Research Institute
2013
We assessed the neurodevelopment of infants with and without deformational plagiocephaly (DP), at an average age 6 months.The Bayley Scales Infant Development III (BSID-III) were administered to 235 case subjects 237 demographically similar, control participants. Three-dimensional head photographs randomized rated for severity deformation by 2 craniofacial dysmorphologists who blinded status.We excluded no photographic evidence DP 70 judged have some degree DP. With age, gender,...
Evidence suggests that high-heat cooking methods may increase the risk of prostate cancer (PCa). The addition oil/fat, as in deep-frying, be particular concern, and has not specifically been investigated relation to PCa. Potential mechanisms include formation potentially carcinogenic agents such aldehydes, acrolein, heterocyclic amines, polycyclic aromatic hydrocarbons, acrylamide.We estimated odds ratios (OR) 95% confidence intervals (CI) for association between tertiles intake deep-fried...
Abstract Background: The matrix metalloproteinases (MMP) cause degradation of the extracellular and basement membranes, thus may play a key role in cancer development. Methods: In our search for biomarkers oral squamous cell carcinomas (OSCC), we compared primary OSCC, dysplasia control subjects with respect to: (i) expression MMP1, MMP3, MMP10, MMP12 epithelial tissue using Affymetrix U133 2.0 Plus GeneChip arrays, followed by quantitative reverse transcription-PCR (qRT-PCR) (ii)...
Abstract Background: A history of diabetes is associated with an increased risk several types cancers. Whether a factor for head and neck cancer (HNC) has received little attention. Methods: We pooled data from 12 case–control studies including 6,448 cases 13,747 controls, estimated OR 95% CI the associations between HNC, adjusted age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, body mass index. Results: observed weak association incidence HNC overall...
Treatment options for patients with ulcerative colitis (UC) or Crohn disease (CD) have increased considerably in recent years the advent of new biologics, but little is known about treatment pathways clinical practice. We aimed to characterize patterns and sequences UC CD newly initiated on a biologic an immunosuppressant (IMS).This retrospective cohort study used US health insurance claims data dated from January 1, 2009, December 31, 2013, IMS. were described during 24-month follow-up...
Objective To examine reading and related skills in children with without orofacial clefts. Methods Forty-two clefts were recruited from an urban craniofacial center. A demographically similar sample of 43 was using community advertisements a research registry. Participants completed assessments basic reading, phonological awareness, memory, fluency, rapid naming. Parents semi-structured interview regarding educational medical history. Results Children scored significantly lower than controls...
Abstract BACKGROUND Prostate cancer (PC) is the most frequently diagnosed non‐skin malignancy in men Western world, yet few disease‐associated mutations have been found. Recently, a low frequency recurring mutation HOXB13 gene was reported among both hereditary PC families and from general population. MATERIALS AND METHODS We determined distribution of G84E variant 1,310 incipient cases 1,259 age‐mated controls population‐based, case–control study PC. RESULTS The more frequent than (1.3% vs....
One challenge in prostate cancer is distinguishing indolent from aggressive disease at diagnosis. DNA promoter hypermethylation a frequent epigenetic event cancer, but few studies of methylation relation to features more tumors or recurrence have been completed.We used the Infinium HumanMethylation450 BeadChip assess tumor tissue 407 patients with clinically localized who underwent radical prostatectomy. Recurrence status was determined by follow-up patient surveys, medical record review,...
Objective. Oral glucocorticoid (OGC) use for rheumatoid arthritis (RA) is debated because of the adverse event (AE) profile OGC. We evaluated associations between cumulative doses OGC and potential OGC-related AE, quantified associated healthcare expenditures. Methods. Using MarketScan databases, patients ≥ 18 years old who have RA with continuous enrollment from January 1 to December 31, 2012 (baseline), 2013 (evaluation period), were identified. Cumulative dose was measured using...
Our objective was to evaluate whether infants born obese or diabetic women are at higher risk of non-syndromic orofacial clefting. We conducted a population-based case-control study using Washington State birth certificate and hospitalisation data for the years 1987-2005. Cases were with clefts (n = 2153) controls without 18 070). The primary exposures maternal obesity (body mass index > =30) diabetes (either pre-existing gestational). estimated adjusted odds ratios (ORs) compare, mothers...
Abstract Background: Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, date, few causative have been identified. Methods: To identify rare cancer, we conducted whole-exome sequencing (WES) in multiple kindreds (n = 91) from 19 hereditary (HPC) families characterized by aggressive or early-onset phenotypes. Candidate variants 130) identified through family- and bioinformatics-based filtering WES data were then genotyped an independent set 270 HPC 819...
Objective To examine the effects of belimumab initiation on healthcare resource utilisation (HCRU) and costs in SLE. Methods This retrospective observational cohort study used administrative claims data from IBM MarketScan Commercial Claims Encounters Database to identify patients with SLE billing codes who received ≥1 intravenous infusion between March 2011 December 2015. The first administration was ‘index date’. During 6-month postindex period, nine infusions were recommended: three...
Background: This retrospective cohort study aimed to describe and quantify healthcare resource utilization costs for patients with ulcerative colitis (UC) Crohn’s disease (CD) following initiation of biologic therapy. Methods: Resource were analyzed at baseline 1- 2-years after initiating a biologic. Data extracted from US administrative health insurance claims database adults ≥18 years. Eligible continuously enrolled in plan medical pharmacy benefits ≥12 months prior to, 12 (primary...
OBJECTIVE To assess the hypothesis that retinopathies are indicative of systemic microvascular injury. RESEARCH DESIGN AND METHODS The only U.S. national survey assessing hemorrhaging at two distinct anatomical sites was National Health and Nutrition Examination Survey (1988–1994). injury assessed by modeling association retinal gingival factors explain this association. RESULTS Individuals in whom one or more five had a 57% increased odds for (95% CI: 1.26–1.94). This between 51% explained...
Background: Chronic cough and phlegm are frequently reported chronic obstructive pulmonary disease (COPD) symptoms. Prior research classified mucus hypersecretion (CMH) based on the presence of these symptoms for ≥ 3 months, called bronchitis (CB) if respiratory infection were present 1– 2 years (Medical Research Council [MRC] definition). We explored whether COPD Assessment Test (CAT), a simple measure developed routine clinical use, captures CMH populations outcomes similarly to MRC St....
Recently, a genetic variant (rs10993994) in the MSMB gene associated with prostate cancer (PCa) risk was shown to correlate reduced secretory protein of 94 amino acids (PSP94) levels. Although biological activity PSP94 is unclear, one its hypothesized functions protect prostatic cells from pathogens. Number sexual partners and history sexually transmitted infections (STIs) have been positively PCa risk, these associations may be related pathogen-induced chronic inflammation. Based on...
Previous research suggests that weight loss is associated with decreases in health care costs among individuals type 2 diabetes mellitus (T2DM) and change can affect clinical measures, including hemoglobin A1c (A1c), low-density lipoprotein cholesterol (LDLC), blood pressure. has also demonstrated more pronounced impact of patients T2DM who are obese have no evidence cardiovascular disease (CVD).To (a) examine the association between all-cause diabetes-related T2DM; (b) select measures (c)...
<h3>Background</h3> Belimumab, a B-lymphocyte stimulator, was FDA-approved March 2011 for the treatment of adult patients with active, autoantibody-positive SLE receiving standard care medications. There is need to evaluate belimumab9s effectiveness in real-world practice settings. <h3>Objectives</h3> To describe initiating belimumab on flare episodes. <h3>Methods</h3> Patients aged 18–64 years at first infusion (index date) between 01 Jan 2010 – 31 Dec 2014 were selected from US Truven...