Background A multidisciplinary meeting was held from March 4 to 6, 2010, in Atlanta, Georgia, entitled “Craniosynostosis: Developing Parameters for Diagnosis, Treatment, and Management.” The goal of this create parameters care individuals with craniosynostosis. Methods Fifty-two conference attendees represented a broad range expertise, including anesthesiology, craniofacial surgery, dentistry, genetics, hand neurosurgery, nursing, ophthalmology, oral maxillofacial orthodontics,...

We compared the developmental status of school-age children with single-suture craniosynostosis (case group) and unaffected (control group). Within case group we performance distinguished by location suture fusion (sagittal, metopic, unicoronal, lambdoid).

This study examined the global intellectual development and presence/absence of learning disorders in children with nonsyndromic metopic, sagittal, unilateral coronal synostosis who had early surgery (under 1 year age), late (over or no to correct across three time periods.The design was longitudinal. Children were assessed at initial team evaluation, after evaluation if not performed, annually thereafter.Participants included 84 consecutively evaluated patients. Seventy-two Time (T1), 8...

Object Although most infants with single-suture craniosynostosis (SSC) appear to have neurodevelopmental test scores in the average range, SSC has been associated cognitive and motor delays during infancy. Whether when surgery improves such deficits are not yet known. The authors aimed compare pre- postsurgical status of patients those control without craniosynostosis. Methods conducted a large, multicenter, longitudinal study 168 115 controls synostosis who were similar age, race, sex,...

Abstract Craniosynostosis, the premature fusion of one or more cranial sutures, affects 1 in 2,500 live births. Isolated single‐suture is most prevalent, with sagittal synostosis occurring 1/5,000 The etiology isolated (nonsyndromic) craniosynostosis largely unknown. In syndromic craniosynostosis, there a highly nonrandom pattern causative autosomal dominant mutations involving TWIST1 and fibroblast growth factor receptors ( FGFRs ). Prior to our study, were no published anti‐osteogenic...

<h3>Objective</h3>To evaluate the hypothesis that 3-year-old children with single-suture craniosynostosis would receive lower neurodevelopmental scores than a comparable group of born patent sutures.<h3>Design</h3>Longitudinal comparison study.<h3>Setting</h3>Five tertiary care craniofacial centers.<h3>Participants</h3>Patients (cases) and without (controls). Patients diagnosed from 2002 to 2006 were eligible as cases. Controls frequency-matched cases on age, sex, race, socioeconomic status,...

The effect of cranial release and reconstruction on the mental development infants with nonsyndromic craniosynostosis was evaluated. Longitudinal assessment for before after not undergoing surgical treatment obtained by using scale Bayley Scales Infant Development. Severity anatomic craniofacial deformity, perinatal medical risk factors, age at time surgery also were investigated. None displayed retardation [Mental Development Index (MDI) score < 70] or reconstruction. Scores ranged from...

The effect of cranial release and reconstruction on the mental development infants with nonsyndromic craniosynostosis was evaluated. Longitudinal assessment for before after not undergoing surgical treatment obtained by using scale Bayley Scales Infant Development. Severity anatomic craniofacial deformity, perinatal medical risk factors, age at time surgery also were investigated. None displayed retardation [Mental Development Index (MDI) score < 70] or reconstruction. Scores ranged from...

This study examined social interactions of adolescents in a natural environment (school lunch room) to determine if there were identifiable differences behavior between children with and without craniofacial conditions (CFC).This was an observational comparing interaction skills CFC peers conditions.The observations conducted the respective school rooms CFC.Clinical subjects 13 (4 male) various (5 cleft lip palate) 12 present same room.An unknown observer obtained 45 minutes structured data...

Objective: To describe the Facial Differences Module of Youth Quality Life Instruments (YQOL-FD) and present results evaluating domain structure, internal consistency, reproducibility, validity, respondent burden. Design: A multisite observational study youth aged 11 to 18 years with acquired or congenital facial differences. Participants: Three hundred seven recruited through clinics at four U.S. sites one U.K. site. Eligible were years, had a noticeable difference, could read fifth-grade...

Children with single-suture craniosynostosis (SSC) have higher rates of learning disabilities and related neurocognitive problems than unaffected peers. Executive function (EF) attention are thought to be areas particular vulnerability, though studies date been limited by small sample sizes a lack control groups. We evaluated 179 school-aged children SSC (cases) 183 controls at an average age 7 years using clinician-administered parent teacher report measures EF attention. Among SSC, we...

OBJECTIVE The language and memory functions of children with without single-suture craniosynostosis (SSC) were compared at school age (mean 7.45 years, standard deviation [SD] 0.54 years). in this cohort originally recruited infancy prior to cranial surgery for those SSC. METHODS Individual evaluations 179 school-aged SSC 183 controls conducted (70% the original cohort) using standardized measures language, learning, memory. Parents participated an interview about specialized education...

Objective To evaluate the cognitive and language development of untreated infants with a single suture craniosynostosis at time diagnosis. Design Participants The study presents 1 assessments on first 100 (sagittal, metopic, unilateral coronal, lambdoid) referred to Infant Learning Project, prospective, multisite, longitudinal evaluating neurocognitive development. Main Outcome Measures Infants were assessed mental (Mental Development Index [MDI]) motor scales (Psychomotor Developmental...

Objective To examine reading and related skills in children with without orofacial clefts. Methods Forty-two clefts were recruited from an urban craniofacial center. A demographically similar sample of 43 was using community advertisements a research registry. Participants completed assessments basic reading, phonological awareness, memory, fluency, rapid naming. Parents semi-structured interview regarding educational medical history. Results Children scored significantly lower than controls...

Abstract Objective: To evaluate associations between neurodevelopment and exposure to surgery anesthetic agents in children with single‐suture craniosynostosis (SSC). Background: Young SSC have unexplained neurodevelopmental delays. The possible contributions of factors related cranial vault – including anesthesia not been previously examined. Methods/materials: Two anesthesiologists reviewed the surgical records 89 infants (70 had complete data). Primary exposures were duration total...

Background: Previous research has observed higher than average rates of behavior problems in school-age children with single-suture craniosynostosis. However, most studies used a single informant (mothers) and did not include comparison groups to control for sociodemographic factors. Methods: The authors gave standardized checklists the mothers, fathers, teachers 179 elementary school craniosynostosis 183 controls. We linear regression compare without on continuous measures adjustment,...

To determine associations of demographic, morphologic, and treatment protocol parameters with quality life (QoL), appearance/speech satisfaction, psychological adjustment.

OBJECTIVES To measure severity of trigonocephaly among infants with single-suture metopic craniosynostosis by using a novel shape descriptor, the index (TSI), and to evaluate whether degree correlates their neurodevelopmental test scores. METHODS We conducted multicenter cross-sectional longitudinal study, identifying recruiting 65 synostosis before corrective surgery. obtained computed tomography images for 49 measured presurgical TSI, 3-dimensional outline-based cranial descriptor....

Background: The purpose of this study was to confirm initial reports elevated behavior problems in children with single-suture craniosynostosis, using multiple informants, longitudinal analyses, and a control group. authors hypothesized that craniosynostosis would have higher levels maladjustment than comparison children, particularly at the older age selected areas previously observed vulnerability: attention social adjustment. Methods: Child Behavior Checklist completed by 436 mothers (219...