A5023255933- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Total Knee Arthroplasty Outcomes
- Obstructive Sleep Apnea Research
- Osteoarthritis Treatment and Mechanisms
- Dementia and Cognitive Impairment Research
- Hepatitis Viruses Studies and Epidemiology
- Asthma and respiratory diseases
- Prenatal Screening and Diagnostics
- Knee injuries and reconstruction techniques
- Congenital Ear and Nasal Anomalies
- Sexual Differentiation and Disorders
- Allergic Rhinitis and Sensitization
- Adolescent and Pediatric Healthcare
- Neuroscience of respiration and sleep
- Cardiac Structural Anomalies and Repair
- Neurogenetic and Muscular Disorders Research
- Bone health and osteoporosis research
- Coronary Artery Anomalies
- Frailty in Older Adults
- Reproductive Health and Technologies
- Kawasaki Disease and Coronary Complications
University of Pittsburgh
2009-2019
University of Arizona
2015
Michigan State University
2009
University of Washington
2007-2008
Seattle Epidemiologic Information and Research Center
2007
University of Puget Sound
2007
Abstract Introduction We compared risk of progression from subjective cognitive decline (SCD) to mild impairment (MCI) in an academic memory clinic versus a population‐based study. Methods Older adults presenting at were classified as SCD (n = 113) or noncomplainers 82). Participants population study 592) and 589) based on complaint score. Annual follow‐up performed for mean 3 years. Results The adjusted hazard ratio was 15.97 (95% confidence interval: 6.08–42.02, P < .001) the 1.18...
ABSTRACT Cytokines play major roles in regulating bone remodeling, but their relationship to incident fractures older men is uncertain. We tested the hypothesis that with higher concentrations of pro-inflammatory markers have a risk fracture. used case-cohort design and measured inflammatory random sample 961 including 120 clinical vertebral, 117 hip, 577 non-spine fractures; average follow-up 6.13 years (7.88 for vertebral fractures). interleukin (IL)-6, C-reactive protein (CRP), tumor...
Object Although most infants with single-suture craniosynostosis (SSC) appear to have neurodevelopmental test scores in the average range, SSC has been associated cognitive and motor delays during infancy. Whether when surgery improves such deficits are not yet known. The authors aimed compare pre- postsurgical status of patients those control without craniosynostosis. Methods conducted a large, multicenter, longitudinal study 168 115 controls synostosis who were similar age, race, sex,...
Introduction: Patient preferences contribute to marked racial disparities in the utilization of total knee replacement (TKR).The objectives this study were identify determinants osteoarthritis (OA) patients' regarding TKR by race and variables that may mediate differences willingness undergo TKR.Methods: Five hundred fourteen White (WH) 285 African-American (AA) patients with chronic pain radiographic evidence OA participated study.Participants recruited from community, an academic medical...
Hemifacial microsomia (HFM) is a variable, complex malformation involving asymmetric hypoplasia of the face and ear. Little known about risk factors for or consequences HFM. In this study, we describe 3 studies that have been are currently being conducted to further our understanding malformation. The first completed study examined whether HFM related maternal exposures may affect blood flow. case-control interview data from 230 mothers children in case group 678 control suggested use...
Objective To determine whether psychosocial functioning in children with orofacial clefts and their parents differs from that unaffected controls. Design The study used a nonrandomized, case-control design. Participants Outcomes were evaluated 93 cases 124 controls, aged 5 to 9 years, who part of the Massachusetts Center for Birth Defects Research Prevention registry. Main Outcome Measures included Child Behavior Checklist, PedsQL 4.0, Social Competence Scale, Parenting Stress Inventory....
Objective To evaluate the hypothesis that children with craniosynostosis and their parents have differences in psychosocial outcomes, as compared an unaffected control group. Design Two studies were conducted, both which followed born without craniosynostosis. Study 1 ascertained affected from clinics, study 2 a population-based of birth defects. Participants included 22 single-suture 18 controls, ages 4 to 5 years. 24 nonsyndromic 124 9 Main Outcome Measures measures Child Behavior...
To determine whether there are racial differences in social support among patients with knee osteoarthritis (OA) and the impact of on patient preferences for total replacement (TKR) varies by race sex.
<h3>Objective</h3> To determine whether preadolescent children with hemifacial microsomia (HFM) have higher risk of neurodevelopmental delays than unaffected control individuals. <h3>Design</h3> Case-control follow-up study neurodevelopment in and without HFM. <h3>Setting</h3> Case individuals were originally recruited from 26 craniofacial centers across the United States Canada, controls through community pediatricians. <h3>Participants</h3> One hundred thirty-six HFM (cases) 568...
Article AbstractObjective: To estimate the incidence of psychotic symptoms in Alzheimer's disease.Methods: The study consists 776 elderly subjects presenting to Alzheimer Disease Research Center at University Pittsburgh (Pittsburgh, Pennsylvania) between May 9, 2000, and August 19, 2014. All participants were diagnosed with mild cognitive impairment (National Institute on Aging-Alzheimer's Association workgroup criteria) or possible probable disease Neurologic Communicative Disorders Stroke...
Children with craniofacial anomalies are at high risk for sleep-disordered breathing (SDB), yet its prevalence among children conditions is not known. hemifacial microsomia (HFM) likely particularly vulnerable to SDB as a result of underdevelopment the mandible and oropharynx. Nevertheless, most HFM referred sleep studies. We hypothesized that outcomes would be worse in versus control subjects.We conducted follow-up study 124 case participants 349 subjects who previously participated...
Abstract Using two versions of the A-not-B task, memory and response inhibition were assessed in 17- to 24-month-old children with surgically corrected single-suture craniosynostosis (cases) unaffected (controls). Children's development language initially on average at 6–7 months age again this second visit. Cases controls performed equivalent levels average, cases performing slightly better than several variables measured. However, fewer able complete more challenging tasks, which may have...
The aim of the study was to define chronic HBV phenotypes in a large, cohort United States and Canadian children utilizing recently published population-based upper limit normal alanine aminotransferase levels (ULN ALT), compared with local laboratory ULN; identify relationships host viral factors.Chronic hepatitis B virus (HBV) infection has been characterized by phases or phenotypes, possibly associated prognosis indications for therapy.Baseline enrollment data Hepatitis Research Network...
Summary Antiviral drug resistance hepatitis B virus (HBV) variants ( HBV ‐ DR ) occur spontaneously in chronic CHB patients and after exposure to nucleos(t)ide analogues NUC s). We determined the prevalence of among participants Hepatitis Research Network HBRN Cohort Study conducted at 21 sites United States US Canada. Samples obtained from 1342 aged ≥18 years, who were currently not receiving s, tested for by Sanger sequencing. In addition, next generation sequencing NGS was used...
Summary There is a considerable body of literature on the causes female infertility, but far less known about male factor infertility. We conducted classical twin study to estimate genetic influence 12‐month The used Vietnam Era Twin (VET) Registry, which includes pairs born between 1939 and 1957, who served in US military 1965 1975. In 1987, health survey was mailed all twins obtained 74% response rate. current analyses comprised 1795 complete both were married only once. Proband‐wise...
The aim of the study was to determine whether selected sociodemographic and hepatitis B virus (HBV)-specific clinical factors are associated with health-related quality life (HRQoL) among pediatric patients chronically infected HBV.Children chronic HBV enrolled in Hepatitis Research Network completed Child Health Questionnaire at entry. Caregivers children 5 <10 years parent-reported form (CHQ-Parent Report Form); youth 10 <18 child-reported CHQ-Child Form. We examined univariable...
To compare risk for sleep-disordered breathing between children with and without single-suture craniosynostosis.